"Like many other P. aeruginosa-response genes, induction of
irg-1 mRNA by PA14 is PMK-1 independent, as demonstrated by qRT-PCR (Fig 1A). Similarly,
irg-2 (C49G7.5) and
irg-3 (F53E10.4) are PMK-1 independent, whereas F49F1.6, is PMK-1 dependent, as previously shown (Fig 1A). Because
pmk-1(
km25) is a null mutation in the terminal kinase of the PMK-1
p38 MAPK pathway, it appears that the PMK-1
p38 MAPK pathway is not required for induction of
irg-1."