"2-BTHF-treated CL4176 worms exhibited a moderate upregulation of
bec-1 (encoding the protein that initiates autophagy induction) and significant increases of
lgg-1 (autophagosome elongation),
atg-7 (autophagosome formation), and
lmp-1 (autophagosome-lysosome fusion) mRNA levels, which were higher than untreated controls by approximately 1.5-, 2.1-, and 1.5-folds, respectively, at 36 h after temperature upshift (Figure 5A)."; "These data implied that genes regulating the autophagic pathway were only upregulated by 2-BTHF when A aggregation was presented in the worms, specifically leading to its attenuative action on A-induced toxicity."