del-1 reporter gene expression was significantly affected in the SAB neurons of unc-3 mutants. Consistent with del-1 being transcriptional targets of unc-3, the number of del-1 mRNA molecules is significantly reduced in the SAB neurons of unc-3 mutants.
During the mid-L2 larval stage, del-1::GFP expression in the ventral nerve cord is largely restricted to the VB class of motor neurons. In the unc-37 mutant, del-1::GFP is also expressed ectopically in the VA motor neurons in mid-L2 larvae.
During the mid-L2 larval stage, del-1::GFP expression in the ventral nerve cord is largely restricted to the VB class of motor neurons. In the unc-4 null alleles wd1 and e120, del-1::GFP is also expressed ectopically in the VA motor neurons in mid-L2 larvae.
"The WT protein appears to dimerize through interactions between the first armadillo repeat. In contrast, the model for the DEL dimer indicates that the interaction interface has moved toward the center of the domain."