Loss of mir-71 function in animals lacking germ cells resulted in 50% reduction in the levels of sod-3. Results suggest that mir-71 promotes germline-mediated longevity by regulating the localization and transcriptional activity of DAF-16.
The suppression of mei-1(gf) by ppfr-1(tm2180) was comparable to that of ppfr-1(RNAi). Notably, loss of ppfr-1 does not suppress mei-1(gf) at 25, indicating that ppfr-1 is not a bypass suppressor. The ppfr-1 mutation showed weak dominant suppression of mei-1(gf), most evident in mei-1(gf) homozygotes.