In response to
spg-7(RNAi): "Specifically, ATFS-1 bound the promoters of
nuaf-1 and Y17G9B.5 (ECSIT), two NADH ubiquinone oxidoreductase assembly factors, and
lpd-8 (NFU1), a Fe-S cluster biogenesis component (Figures 6A-6C). These genes were induced during mitochondrial stress* in an
atfs-1-dependent manner (Figures 6D-6F), suggesting a role for ATFS-1 in OXPHOS complex assembly." *
spg-7(RNAi)