"Interestingly, prominent changes in unfolded protein response (UPR) terms 'ER nuclear signaling pathway' and 'response to endoplasmic reticulum stress' (p value = 1.34 10<sup>-4</sup>, Figure 2C) with downregulation of 5 genes of the heat shock-protein family (C12C8.1, T27E4.3/T27E4.9, Y46H3A.2, T27E4.2, and T22A3.2) were observed."
"While interaction of RIC-3 with DEG-3 does not require assembly of DEG-3 with DES-2, it is enhanced by the presence of DES-2, suggesting that RIC-3 prefers DEG-3/DES-2 heteromers to DEG-3 monomers or homomers."
FEM-3 is absent from the distal wild-type adult gremlin detected by anti- FEM-3 antibodies. In nos-3(0), FEM-3 accumulates throughout the distal germline, supporting a role for NOS-3-mediated repression of fem-3 translation in this region.