"For this information, we turned back to our genome-wide RNAi list of hpo genes, examined all eight of the genes that are induced by PFT (2X cut-off), and asked, based on our microarray data, if their induction is dependent upon either the
p38 or JNK MAPK pathways. We found four of eight (50%) induced hpo genes (namely
kin-18, Y54E5A.1, F42C5.10 and
kgb-1 itself) require JNK (namely
kin-18, Y54E5A.1, F42C5.10 and
kgb-1 itself) require JNK MAPK for their induction whereas none of the eight genes require the
p38 MAPK pathway for their induction. The dependence of these four genes upon the KGB-1 and not the
p38 MAPK these four genes upon the KGB-1 and not the
p38 MAPK pathway for their induction was confirmed via qRT-PCR (Figure 3E)."