RNAi of Y57G11C.16 enhanced the reduction of ckb-2p::GFP expression resulting from the cdc-48.2(tm659) mutation, in the presence of the ER-stress inducer tunicamycin
Depletion of either F38C2.5 or Y57G11C.25 singly by RNAi resulted in no observable phenotype, yet depletion of both genes simultaneously by double RNAi resulted in 100 percent embryonic lethality. RNAi animals appear to produce all tissue types but fail to undergo proper morphogenesis and elongation.