The pattern of METT-10::GFP accumulation in the distal germ line is altered in
glp-1 mutants. The germ line expression pattern of METT-10 is altered in both
glp-1 loss-offunction and gain-of-function mutant backgrounds. In line with the finding that METT-10 levels increase as germ cells enter meiosis, nuclear METT-10 is uniformly detected in distally located meiotic nuclei in shifted
glp-1(
bn18) animals in which almost all germ cells have entered meiosis. However, there is also an increase in distal METT-10 levels when the
glp-1(
ar202) gain-of-function mutant is shifted to 25C to induce tumors, although groups of proliferating cells expressing lower levels of METT- 10 can be found throughout the germ line.