"To further explore how
lin-44 might regulate
tlp-1, we analyzed T cell lineages in a
lin-44;
tlp-1 double mutant (Fig 6B). In each lineage it appeared that the polarity of the T cell division was reversed, as it is in
lin-44 single mutants. However, the subsequent cell division patterns were reminiscent of
tlp-1 single mutants, in that we observed the loss of both neural cell fates and cell divisions in four lineages and only the loss of cell divisions in another four lineages. Thus it appears that in
lin-44;
tlp-1 double mutants we observed the effects of both mutations, indicating that
tlp-1 mutants retain some T cell polarity information that can be affected by mutations in
lin-44. In addition,
lin-44 and
tlp-1 appear to interact in the formation of the male tail.
lin-44 males display a weak Lep tail defect that is significantly enhanced by one mutant copy of
tlp-1 (Table 1). This suggests that
tlp-1 might also function with, and perhaps downstream of,
lin-44 in the development of the male tail."