In wild-type and most
vps-29(
tm1320) or
mig-14(
mu71) single mutants, the PLM neurons show a normal polarity. In
mig-14(
mu71);
vps-29 double mutants, however, about a third of the animals show either reversal or loss of PLM polarity. Authors observed a similar synergistic effect on PLM polarity in mig- 14
(ga62);
vps-29 double mutants. Taken together, these results demonstrate that reduction of retromer function strongly enhances the Wnt phenotype of hypomorphic
mig-14 alleles.