The lifespan-extending effect of
frh-1 RNAi was almost completely prevented in the
pdr-1(
gk448) mutant strain. Two additional
pdr-1 alleles (
tm598 and
tm395), as well as
pdr-1 RNAi, also suppressed the lifespan-extending ability of frataxin silencing, thus establishing a clear role for
pdr-1 in frataxin-regulated longevity.