nhr-64(RNAi) increased the triacylglycerol/total lipid (TAG/TL) ratio in sbp-1(ep79) mutants, thereby partially suppressing the reduced TAG/TL ratio caused by the sbp-1 mutation.
Western blot analysis showed a significant 60.7% (+/-3.3%) reduction in FoxO/DAF-16 expression in tmem-135(ok1646) worms compared with wild-type controls. Furthermore, TMEM-135::GFP overexpression led to a 2.0-fold up-regulation of FoxO/DAF-16 levels compared with wild-type controls
nhr-64(RNAi) increased the triacylglycerol/total lipid (TAG/TL) ratio in fat-6;fat-7 double mutants, thereby partially suppressing the reduced TAG/TL ratio caused by the fat-6 and fat-7 mutations.
The expression of PLM gene tag-97 is fully dependent on EGL-5, because tag-97 expression was lost in PLM neurons of egl-5 mutants and was ectopically activated in ALM neurons misexpressing egl-5.