[
2009]
With contributions from more than 40 field specialists, Methods of Behavior Analysis in Neuroscience reflects six years of updates to its first bestselling edition and elucidates new behavioral approaches that are quickly becoming field standards. This second edition features new material on the relevance of transgenic mouse models for Alzheimer's disease, behavioral methods for assessing the cognitive impairment associated with major psychotic disorders, the revival of the scopolamine reversal model for assessing the clinical relevance of new AD drugs, and new approaches to assessing the cognitive impairment in aged mice.
[
1997]
The urgency and importance of properly conducting a risk assessment, and all the various attributes of the assessment, will remain a significant issue for years to come. STP 1317 explores the use of modeling in developing risk assessments for a variety of environmental situations, including human-health assessments, site-specific assessments, and ecosystem-level assessments. 32 peer-reviewed papers examine several aspects to consider when conducting a risk assessment, including: When is Risk Assessment the Right Tool?, Communication of Risk Assessment, Model Selection and Problem Analysis, Data Quality and Uncertainty
[
2010]
The common belief is that human smell perception is much reduced compare to other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely overly simplistic. The Neurobiology of Olfaction provides a thorough analysis of the state-of-the-science in olfactory knowledge and research, reflecting the growing interest in the field. Authors from some of the most respected laboratories in the world explore various aspects of olfaction, including genetics, behavior, olfactory systems, odorant receptors, odor coding, and cortical activity. Until recently, almost all animal research in olfaction was carried out on orthonasal olfaction (inhalation). It is only in recent years, especially in human flavor research, that evidence has begun to be obtained regarding the importance of retronasal olfaction (exhalation). These studies are beginning to demonstrate that retronasal smell plays a large role in human behavior. Highlighting common principles among various species-including humans, insects, Xenopus laevis (African frog), and Caenorhabditis elegans (nematodes)-this highly interdisciplinary book contains chapters about the most recent discoveries in odor coding from the olfactory epithelium to cortical centers. It also covers neurogenesis in the olfactory epithelium and olfactory bulb. Each subject-specific chapter is written by a top researcher in the field and provides an extensive list of reviews and original articles for students and scientists interested in further readings.
[
2011]
The rapid expansion of the TRP field has generated a large amount of excellent original work across many different research fields. However, investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic diversity, as well as the different physiological roles they play, techniques used for studying TRP channels range from single molecular analysis to behavioral animal studies. Methods in multiple areas, such as molecular biology, fluorescence imaging, electrophysiology, cell biology, genetics, proteomics, pharmacology, system physiology, and behavioral assessment, are employed to investigate various aspects of these channels. Choosing among many possible topics in these broad areas was a daunting task. A comprehensive review of the field, TRP Channels spans the information gap by providing broad coverage of current methods and techniques commonly used in TRP channel research, and detailed protocols with thorough discussions of the advantages and disadvantages across methods. Some topics covered include 1. Mammalian, Drosophila and C. elegans TRP channels. 2. Practical protocols for functional studies of TRP channels, including TRPC, TRPV, TRPA, TRPM and the intracellularly localized TRPML channels. 3. ThermoTRPs, including the new fast temperature jump apparatus and the high throughput random mutagenesis method for screening critical motifs involved in TRP channel regulation. 4. Cell-based high-throughput screening assays for TRP channels and their applications in drug discoveries. 5. TRP channel functions in native cells, including smooth muscles, neurons, and cancers. Showcasing the current status of the field, TRP Channels covers the major techniques used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Because of the breadth of the TRP field, the applications of some methods are described in multiple chapters by experts working on a variety of channel types that serve different physiological functions, highlighting distinctive views on how the methodology can be utilized. Some chapters include discussion on the usefulness and pitfalls associated with the use of certain techniques. Together with chapters that offer comprehensive reviews on the functional regulation and other roles of TRP channels, students and investigators new to the field should find this book particularly informative.