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Genome Res,
2000]
Whole -genome sequence comparisons between bacterial sequences are one thing, but try comparing two eukaryotic genomes, each containing tens or hundreds of millions of nucleotides. And try to do it on your desktop machine in your office or at home. That is what Kent and Zahler have tried, and the results are presented in this issue of Genome Research. The use of evolutionary conservation to unveil functional information contained within genomes is not new. In the case of the nematode, comparisons of Caenorhabditis elegans to its close relative Caenorhabditis briggsae go back as far as Emmons et al.