-
[
Development & Evolution Meeting,
2008]
No abstract submitted
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[
Development & Evolution Meeting,
2008]
No abstract submitted
-
[
Development & Evolution Meeting,
2008]
No abstract submitted
-
[
Development & Evolution Meeting,
2008]
No abstract submitted.
-
[
Development & Evolution Meeting,
2008]
No abstract submitted
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[
Worm Breeder's Gazette,
1998]
Correction: "The abstract entitled Control of Mitochondrial Morphology published in WBG Vol. 15 No. 1 contained an error. Worms were treated with 3 mM (not 100 mM) chloramphenicol to induce changes in mitochondrial morphology. Thanks to A.L. for spotting the error. M. Crawley & D. Adams
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[
Nat Rev Genet,
2003]
Many crucial decisions, such as the location and timing of cell division, cell-fate determination, and embryonic axes establishment, are made in the early embryo, a time in development when there is often little or no transcription. For this reason, the control of variation in gene expression in the early embryo often relies on post-transcriptional control of maternal genes. Although the early embryo is rife with translational control, controlling mRNA activity is also important in other developmental processes, such as stem-cell proliferation, sex determination, neurogenesis and erythropoiesis.
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Gusarov, Ivan, Gautier, Laurent, Smolentseva, Olga, Mironov, Alexander, Shamovsky, Ilya, Nudler, Evgeny, Eremina, Svetlana
[
International Worm Meeting,
2013]
Organisms ranging from bacteria to human synthesize NO by a family of enzymes known as NO-synthases (NOS). Small, freely diffusible and short-lived NO possesses the properties of an ideal signaling molecule. It is involved in numerous physiological and pathological processes in mammals. The vital role NO in vasodilation, inhibition of platelet aggregation, neuronal transmission, and cytotoxic activity has been well documented. Surprisingly the round worm Caenorhabditis elegans lacks its own NOS. However, in its natural environment C. elegans feeds on bacteria that possess functional NOS. Here we demonstrate that Bacillus subtilis-derived NO increases C. elegans longevity and stress resistance. NO upregulate the expression of 65 genes that function under the dual control of HSF-1 and DAF-16 transcription factors. Our work provides an example of interspecies signaling by a small molecule and illustrates the life-long value of commensal bacteria to their host.
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[
Elife,
2018]
Nitric oxide (NO) is released into the air by NO-producing organisms; however, it is unclear if animals utilize NO as a sensory cue. We show that <i>C. elegans</i> avoids <i>Pseudomonas aeruginosa</i> (PA14) in part by detecting PA14-produced NO. PA14 mutants deficient for NO production fail to elicit avoidance and NO donors repel worms. PA14 and NO avoidance are mediated by a chemosensory neuron (ASJ) and these responses require receptor guanylate cyclases and cyclic nucleotide gated ion channels. ASJ exhibits calcium increases at both the onset and removal of NO. These NO-evoked ON and OFF calcium transients are affected by a redox sensing protein, TRX-1/thioredoxin. TRX-1's trans-nitrosylation activity inhibits the ON transient whereas TRX-1's de-nitrosylation activity promotes the OFF transient. Thus, <i>C. elegans</i> exploits bacterially produced NO as a cue to mediate avoidance and TRX-1 endows ASJ with a bi-phasic response to NO exposure.
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[
Cell,
2013]
Nitric oxide (NO) is an important signaling molecule in multicellular organisms. Most animals produce NO from L-arginine via a family of dedicated enzymes known as NO synthases (NOSes). A rare exception is the roundworm Caenorhabditis elegans, which lacks its own NOS. However, in its natural environment, C. elegans feeds on Bacilli that possess functional NOS. Here, we demonstrate that bacterially derived NO enhances C. elegans longevity and stress resistance via a defined group of genes that function under the dual control of HSF-1 and DAF-16 transcription factors. Our work provides an example of interspecies signaling by a small molecule and illustrates the lifelong value of commensal bacteria to their host.