[
Biochem J,
1996]
The MAGUKs are a family of membrane-associated guanylate kinases characterized by a common set of domains that bind polypeptide and nucleotide ligands. These domains are a guanylate kinase-like (GUK) domain, an SH3 domain, and one to three copies of a structure known as a PDZ or DHR domain. The PDZ/DHR domain was defined by homology with the Drosophila tumour suppressor discs-large (DLG), the post-synaptic density protein PSD-95 and the tight-junction protein Z0-1, and has recently been defined as a domain for binding polypeptide ligands. The three domain types that define MAGUKs are therefore all ligand-binding domains specialized either for binding polypeptides (PDZ, SH3) or nucleotides (GUK)...