Fibroblast growth factor receptors (FGFRs) regulate diverse biological processes in eukaryotes. The nematode <i>Caenorhabditis elegans</i> is a good animal model for studying the roles of FGFR signaling and its mechanism of regulation. In this study, we report that KIN-9 is an FGFR homolog in <i>C. elegans</i> that plays essential roles in aging and stress response maintenance. <i>
kin-9</i> was discovered as a target of <i>miR-246</i>, a microRNA that is positively regulated by the Axin family member <i>
pry-1</i>. We found that animals lacking <i>
kin-9</i> function were long-lived and resistant to chemically induced stress. Furthermore, they showed a reduced expression of endoplasmic reticulum unfolded protein response (ER-UPR) pathway genes, suggesting that <i>
kin-9</i> is required to maintain a normal ER-UPR. The analysis of GFP reporter-based expression in transgenic animals revealed that KIN-9 is localized in the intestine. Overall, our findings demonstrate that <i>
kin-9</i> is regulated by <i>miR-246</i> and may function downstream of <i>
pry-1</i>. This study prompts future investigations to understand the mechanism of miRNA-mediated FGFR function in maintaining aging and stress response processes.