- excess intestinal cells
Animals contain an excess number of intestinal cells compared to control. In C. elegans, intestinal cells are derived from E-blastomere. The overproduction of intestinal tissues is a result of other blastomeres adopting an E-like fate or excess cell proliferation in the E lineage.
- E lineage variant
The descendants of the E blastomere exhibit altered developmental programs compared to their counterparts in control animals.
- no Intestine
Embryos fail to generate cells that exhibit intestinal specification. In C. elegans, the E blastomere is the precursor of all the intestinal cells.
- cytoplasmic RNAi defective
Animals fail to silence cytoplasmic-localized RNAs. Nuclear-localized RNAs may still be sensitive to RNAi.
- unfertilized oocytes laid
Animals lay inactivated oocytes. In C elegans this may be due to perturbations that eliminate spermatogenesis or result in the production of defective sperm.
- foraging hyperactive
Animals extend intensity of roaming and or dwelling activity compared to control animals. In C. elegans, hyperactivity may include an increase in nose-lifts per minute.
- reduced levels of reduced glutathione
Animals exhibit a decrease in the cellular levels of reduced glutathione (GSH), compared to control. Reduced levels of GSH may be an indication of susceptibility to oxidative stress.