Figure 6.
unc-86 promotes the transcription ofcfi-1 in the URA and IL2 neurons. (A) Wild-type animal expressing
cfi-1::GFP. URA and AVD neurons are indicated. (B) Quantitation of
cfi-1::GFP staining for wild-type animals. (%URA, %AVD) The percentage of animals expressing
cfi-1::GFP in at least a single URA or AVD neuron; (n) number of animals observed. (C)
cfi-1::GFP expression in an
unc-86(
n846) mutant animal. Note the absence of anterior neuronal staining. (D) Quantitation of
cfi-1::GFP staining for
unc-86(
n846)mutant animals; (%URA, %AVD, n) as in B. (E) Models for regulation of CEM fate in URA/IL2 and CEM neurons. In the URA and IL2 neurons,
unc-86 andlin-32 can promote CEM fate development (as indicated by expression of
pkd-2), but
cfi-1, which is also activated by
unc-86, inhibits expression of this fate. In the CEM neurons,
cfi-1 is inactive; thus,
unc-86 andlin-32 can function to promote CEM differentiation.