• DES-2, isoform a
  • Caenorhabditis elegans
  • DES-2, isoform b
  • Caenorhabditis elegans
  • Bma-DES-2
  • Brugia malayi
  • Cbr-DES-2
  • Caenorhabditis briggsae
  • Ovo-DES-2
  • Onchocerca volvulus
  • Cbn-DES-2
  • Caenorhabditis brenneri
  • Cjp-DES-2
  • Caenorhabditis japonica
  • Cre-DES-2
  • Caenorhabditis remanei
  • ECM31
  • Saccharomyces cerevisiae
    Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
  • PAN5
  • Saccharomyces cerevisiae
    2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE
  • IFM1
  • Saccharomyces cerevisiae
    Mitochondrial translation initiation factor 2
  • PDH1
  • Saccharomyces cerevisiae
    Putative 2-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
  • Alg-2-PC
  • Drosophila melanogaster
    Flybase gene name is Alg-2-PC
  • Hmg-2-PA
  • Drosophila melanogaster
    Flybase gene name is Hmg-2-PA
  • msl-2-PA
  • Drosophila melanogaster
    Flybase gene name is msl-2-PA
  • NT5E-2-PA
  • Drosophila melanogaster
    Flybase gene name is NT5E-2-PA
  • PRE8
  • Saccharomyces cerevisiae
    Alpha 2 subunit of the 20S proteasome
  • spd-2-PA
  • Drosophila melanogaster
    Flybase gene name is spd-2-PA
  • Tret1-2-PA
  • Drosophila melanogaster
    Flybase gene name is Tret1-2-PA
  • Vha14-2-PA
  • Drosophila melanogaster
    Flybase gene name is Vha14-2-PA
  • Vha68-2-PF
  • Drosophila melanogaster
    Flybase gene name is Vha68-2-PF
  • Zip42C.2-PB
  • Drosophila melanogaster
    Flybase gene name is Zip42C.2-PB
  • Ance-2-PA
  • Drosophila melanogaster
    Flybase gene name is Ance-2-PA
  • Dcr-2-PA
  • Drosophila melanogaster
    Flybase gene name is Dcr-2-PA
  • Der-2-PA
  • Drosophila melanogaster
    Flybase gene name is Der-2-PA
  • Fmo-2-PA
  • Drosophila melanogaster
    Flybase gene name is Fmo-2-PA
  • galla-2-PA
  • Drosophila melanogaster
    Flybase gene name is galla-2-PA
  • kl-2-PD
  • Drosophila melanogaster
    Flybase gene name is kl-2-PD
  • Lsd-2-PA
  • Drosophila melanogaster
    Flybase gene name is Lsd-2-PA
  • Mi-2-PB
  • Drosophila melanogaster
    Flybase gene name is Mi-2-PB
  • P5cr-2-PA
  • Drosophila melanogaster
    Flybase gene name is P5cr-2-PA
  • pHCl-2-PB
  • Drosophila melanogaster
    Flybase gene name is pHCl-2-PB
  • RpL37-2-PA
  • Drosophila melanogaster
    Flybase gene name is RpL37-2-PA
  • Vha16-2-PA
  • Drosophila melanogaster
    Flybase gene name is Vha16-2-PA
  • Vha36-2-PA
  • Drosophila melanogaster
    Flybase gene name is Vha36-2-PA
  • VhaAC39-2-PA
  • Drosophila melanogaster
    Flybase gene name is VhaAC39-2-PA
  • Ada1-2-PA
  • Drosophila melanogaster
    Flybase gene name is Ada1-2-PA
  • Atf-2-PA
  • Drosophila melanogaster
    Flybase gene name is Atf-2-PA
  • Drl-2-PC
  • Drosophila melanogaster
    Flybase gene name is Drl-2-PC
  • I-2-PB
  • Drosophila melanogaster
    Flybase gene name is I-2-PB
  • Menl-2-PE
  • Drosophila melanogaster
    Flybase gene name is Menl-2-PE
  • Nup93-2-PA
  • Drosophila melanogaster
    Flybase gene name is Nup93-2-PA
  • Pgam5-2-PA
  • Drosophila melanogaster
    Flybase gene name is Pgam5-2-PA
  • primo-2-PC
  • Drosophila melanogaster
    Flybase gene name is primo-2-PC
  • TfAP-2-PD
  • Drosophila melanogaster
    Flybase gene name is TfAP-2-PD
  • Trf4-2-PB
  • Drosophila melanogaster
    Flybase gene name is Trf4-2-PB
  • Vha100-2-PA
  • Drosophila melanogaster
    Flybase gene name is Vha100-2-PA
  • ari-2-PA
  • Drosophila melanogaster
    Flybase gene name is ari-2-PA
  • cv-2-PA
  • Drosophila melanogaster
    Flybase gene name is cv-2-PA
  • IA-2-PC
  • Drosophila melanogaster
    Flybase gene name is IA-2-PC
  • Indy-2-PB
  • Drosophila melanogaster
    Flybase gene name is Indy-2-PB
  • nerfin-2-PB
  • Drosophila melanogaster
    Flybase gene name is nerfin-2-PB
  • Ntf-2-PE
  • Drosophila melanogaster
    Flybase gene name is Ntf-2-PE
  • p24-2-PB
  • Drosophila melanogaster
    Flybase gene name is p24-2-PB
  • qkr58E-2-PB
  • Drosophila melanogaster
    Flybase gene name is qkr58E-2-PB
  • Reg-2-PA
  • Drosophila melanogaster
    Flybase gene name is Reg-2-PA
  • Smyd4-2-PA
  • Drosophila melanogaster
    Flybase gene name is Smyd4-2-PA
  • tbrd-2-PA
  • Drosophila melanogaster
    Flybase gene name is tbrd-2-PA
  • VhaPPA1-2-PB
  • Drosophila melanogaster
    Flybase gene name is VhaPPA1-2-PB
  • Hsc70-2-PA
  • Drosophila melanogaster
    Flybase gene name is Hsc70-2-PA
  • pen-2-PB
  • Drosophila melanogaster
    Flybase gene name is pen-2-PB
  • RluA-2-PD
  • Drosophila melanogaster
    Flybase gene name is RluA-2-PD
  • sens-2-PB
  • Drosophila melanogaster
    Flybase gene name is sens-2-PB
  • SmydA-2-PA
  • Drosophila melanogaster
    Flybase gene name is SmydA-2-PA
  • APS2
  • Saccharomyces cerevisiae
    Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
  • YLR154C-G
  • Saccharomyces cerevisiae
    Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2
  • l(2)03659-PC
  • Drosophila melanogaster
    Flybase gene name is l(2)03659-PC
  • l(2)05287-PB
  • Drosophila melanogaster
    Flybase gene name is l(2)05287-PB
  • l(2)05714-PB
  • Drosophila melanogaster
    Flybase gene name is l(2)05714-PB
  • l(2)10685-PA
  • Drosophila melanogaster
    Flybase gene name is l(2)10685-PA
  • l(2)34Fc-PB
  • Drosophila melanogaster
    Flybase gene name is l(2)34Fc-PB
  • l(2)34Fd-PA
  • Drosophila melanogaster
    Flybase gene name is l(2)34Fd-PA
  • l(2)41Ab-PA
  • Drosophila melanogaster
    Flybase gene name is l(2)41Ab-PA
  • l(2)efl-PC
  • Drosophila melanogaster
    Flybase gene name is l(2)efl-PC
  • l(2)k05819-PA
  • Drosophila melanogaster
    Flybase gene name is l(2)k05819-PA
  • l(2)k14505-PB
  • Drosophila melanogaster
    Flybase gene name is l(2)k14505-PB
  • c(2)M-PA
  • Drosophila melanogaster
    Flybase gene name is c(2)M-PA
  • l(2)gl-PJ
  • Drosophila melanogaster
    Flybase gene name is l(2)gl-PJ
  • l(2)k05911-PC
  • Drosophila melanogaster
    Flybase gene name is l(2)k05911-PC
  • l(2)k09022-PA
  • Drosophila melanogaster
    Flybase gene name is l(2)k09022-PA
  • l(2)k10201-PA
  • Drosophila melanogaster
    Flybase gene name is l(2)k10201-PA
  • l(2)SH0834-PA
  • Drosophila melanogaster
    Flybase gene name is l(2)SH0834-PA
  • ms(2)34Fe-PA
  • Drosophila melanogaster
    Flybase gene name is ms(2)34Fe-PA
  • e(y)2-PA
  • Drosophila melanogaster
    Flybase gene name is e(y)2-PA
  • l(2)dtl-PA
  • Drosophila melanogaster
    Flybase gene name is l(2)dtl-PA
  • l(2)gd1-PB
  • Drosophila melanogaster
    Flybase gene name is l(2)gd1-PB
  • l(2)37Cd-PA
  • Drosophila melanogaster
    Flybase gene name is l(2)37Cd-PA
  • l(2)k01209-PD
  • Drosophila melanogaster
    Flybase gene name is l(2)k01209-PD
  • TfIIA-S-2-PA
  • Drosophila melanogaster
    Flybase gene name is TfIIA-S-2-PA
  • fl(2)d-PA
  • Drosophila melanogaster
    Flybase gene name is fl(2)d-PA
  • Fs(2)Ket-PE
  • Drosophila melanogaster
    Flybase gene name is Fs(2)Ket-PE
  • fs(2)ltoPP43-PA
  • Drosophila melanogaster
    Flybase gene name is fs(2)ltoPP43-PA
  • l(2)09851-PB
  • Drosophila melanogaster
    Flybase gene name is l(2)09851-PB
  • l(2)37Bb-PA
  • Drosophila melanogaster
    Flybase gene name is l(2)37Bb-PA
  • l(2)37Cb-PA
  • Drosophila melanogaster
    Flybase gene name is l(2)37Cb-PA
  • l(2)k09848-PB
  • Drosophila melanogaster
    Flybase gene name is l(2)k09848-PB
  • l(2)k09913-PE
  • Drosophila melanogaster
    Flybase gene name is l(2)k09913-PE
  • ms(2)35Ci-PC
  • Drosophila melanogaster
    Flybase gene name is ms(2)35Ci-PC
  • ref(2)P-PB
  • Drosophila melanogaster
    Flybase gene name is ref(2)P-PB
  • Su(z)2-PC
  • Drosophila melanogaster
    Flybase gene name is Su(z)2-PC
  • APM4
  • Saccharomyces cerevisiae
    Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals
  • Su(var)2-10-PI
  • Drosophila melanogaster
    Flybase gene name is Su(var)2-10-PI
  • ODC2
  • Saccharomyces cerevisiae
    Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism; ODC2 has a paralog, ODC1, that arose from the whole genome duplication
  • Su(var)2-HP2-PA
  • Drosophila melanogaster
    Flybase gene name is Su(var)2-HP2-PA
  • ODC1
  • Saccharomyces cerevisiae
    Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication
  • MRS2
  • Saccharomyces cerevisiae
    Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA
  • TPT1
  • Saccharomyces cerevisiae
    tRNA 2'-phosphotransferase; catalyzes the final step in tRNA splicing, transferring the 2'-PO(4) from the splice junction to NAD(+), forming ADP-ribose 1''-2''cyclic phosphate and nicotinamide; ADP-ribosyltransferase that ADP-ribosylates 5'-phosphorylated ssDNA and ssRNAs; human and mouse orthologs complement the inviability of the yeast null mutant
  • ICL2
  • Saccharomyces cerevisiae
    2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
  • SLM3
  • Saccharomyces cerevisiae
    tRNA-specific 2-thiouridylase; responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human homolog TRMU is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF), and can complement yeast null mutant
  • TRM732
  • Saccharomyces cerevisiae
    Protein involved in 2'-O-methylation of C32 of substrate tRNAs; interacts with 2'-O-ribose methyltransferase Trm7p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene; yeast null mutant can be functionally complemented by human THADA, mutations in which have been implicated in epithelial thyroid adenomas, type 2 diabetes, and polycystic ovary syndrome (PCOS)
  • DGR1
  • Saccharomyces cerevisiae
    Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose
  • DLD2
  • Saccharomyces cerevisiae
    D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix
  • MRPL27
  • Saccharomyces cerevisiae
    Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP
  • YVC1
  • Saccharomyces cerevisiae
    Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
  • IPK1
  • Saccharomyces cerevisiae
    Inositol 1,3,4,5,6-pentakisphosphate 2-kinase; nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable; human IPPK can complement ipk1 null mutant
  • TRM3
  • Saccharomyces cerevisiae
    2'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
  • APL3
  • Saccharomyces cerevisiae
    Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
  • EFT1
  • Saccharomyces cerevisiae
    Elongation factor 2 (eEF2, EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
  • EFT2
  • Saccharomyces cerevisiae
    Eukaryotic translation elongation factor 2 (eEF2, EF-2); also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication
  • DIM1
  • Saccharomyces cerevisiae
    Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; human homolog DIMT1 complements yeast dim1 mutant
  • MPO1
  • Saccharomyces cerevisiae
    Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids; involved in metabolism of phytosphingosine; not an essential gene
  • TRM7
  • Saccharomyces cerevisiae
    2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; yeast null mutant can be functionally complemented by human FTSJ1, mutations in which have been implicated in nonsyndromic X-linked intellectual disability (NSXLID)
  • CUP1-2
  • Saccharomyces cerevisiae
    Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-2 has a paralog, CUP1-1, that arose from a segmental duplication
  • GPM1
  • Saccharomyces cerevisiae
    Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
  • CUP1-1
  • Saccharomyces cerevisiae
    Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-1 has a paralog, CUP1-2, that arose from a segmental duplication
  • ARO1
  • Saccharomyces cerevisiae
    Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
  • ALR1
  • Saccharomyces cerevisiae
    Plasma membrane Mg(2+) transporter; expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; magnesium transport defect of the null mutant is functionally complemented by either of the human genes MAGT1 and TUSC3 that are not orthologous to ALR1
  • ERR2
  • Saccharomyces cerevisiae
    Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant
  • ALR2
  • Saccharomyces cerevisiae
    Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition
  • TRM9
  • Saccharomyces cerevisiae
    tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
  • RIT1
  • Saccharomyces cerevisiae
    Initiator methionine 2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
  • YER152C
  • Saccharomyces cerevisiae
    Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
  • RPS6A
  • Saccharomyces cerevisiae
    Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication
  • DOG1
  • Saccharomyces cerevisiae
    2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae
  • RPS6B
  • Saccharomyces cerevisiae
    Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
  • PFK26
  • Saccharomyces cerevisiae
    6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
  • TRM13
  • Saccharomyces cerevisiae
    2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
  • ERR3
  • Saccharomyces cerevisiae
    Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant in glucose
  • YLR345W
  • Saccharomyces cerevisiae
    Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
  • PRK1
  • Saccharomyces cerevisiae
    Ser/Thr protein kinase; regulates the organization and function of the actin cytoskeleton; inhibits clathrin-mediated endocytosis; phosphorylates the Pan1p and Sla1p subunits of the Pan1p-Sla1p-End3p complex, resulting in inhibition of complex formation; inhibits Scd5p through phosphorylation; phosphorylates Pan1p-interacting proteins, Ent1/2 and Yap1801/2; negatively regulated through autophosphorylation; functional overlap with ARK1
  • CYC7
  • Saccharomyces cerevisiae
    Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication
  • DOG2
  • Saccharomyces cerevisiae
    2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae
  • RIB3
  • Saccharomyces cerevisiae
    3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase); required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
  • LYS14
  • Saccharomyces cerevisiae
    Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
  • LSO1
  • Saccharomyces cerevisiae
    Protein with a potential role in response to iron deprivation; transcription increases during iron deprivation and during treatment with 2-(6-benzyl-2-pyridyl)quinazoline (BPQ) and copper; regulated by Aft1p and, to a lesser extent, by Aft2p; originally identified as a syntenic homolog of an Ashbya gossypii gene; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions
  • PUT4
  • Saccharomyces cerevisiae
    Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
  • LPP1
  • Saccharomyces cerevisiae
    Lipid phosphate phosphatase; catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
  • APL1
  • Saccharomyces cerevisiae
    Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex
  • GPM3
  • Saccharomyces cerevisiae
    Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM3 has a paralog, GPM2, that arose from the whole genome duplication
  • CIT3
  • Saccharomyces cerevisiae
    Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
  • GPM2
  • Saccharomyces cerevisiae
    Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM2 has a paralog, GPM3, that arose from the whole genome duplication
  • NOP56
  • Saccharomyces cerevisiae
    Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
  • ARG81
  • Saccharomyces cerevisiae
    Zinc finger transcription factor involved in arginine-responsive genes; Zn(2)-Cys(6) binuclear cluster domain type; involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
  • YOL057W
  • Saccharomyces cerevisiae
    Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers
  • DGR2
  • Saccharomyces cerevisiae
    Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds; DGR2 has a paralog, YMR102C, that arose from the whole genome duplication
  • NYV1
  • Saccharomyces cerevisiae
    v-SNARE component of vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in vacuolar membrane; targeted to vacuole via AP-3 pathway
  • PFK27
  • Saccharomyces cerevisiae
    6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
  • CHA4
  • Saccharomyces cerevisiae
    DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
  • DLD3
  • Saccharomyces cerevisiae
    2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm
  • ART10
  • Saccharomyces cerevisiae
    Protein of unknown function that contains 2 PY motifs; ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene
  • LEU4
  • Saccharomyces cerevisiae
    Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
  • ALE1
  • Saccharomyces cerevisiae
    Broad-specificity lysophospholipid acyltransferase; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
  • DPH5
  • Saccharomyces cerevisiae
    Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
  • QCR2
  • Saccharomyces cerevisiae
    Subunit 2 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
  • KIP1
  • Saccharomyces cerevisiae
    Kinesin-related motor protein; tracks plus-ends and stabilizes microtubules; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
  • YLR154C-H
  • Saccharomyces cerevisiae
    Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-2; YLR154C-H has a paralog, YLR157C-C, that arose from a segmental duplication
  • IPT1
  • Saccharomyces cerevisiae
    Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
  • YRM1
  • Saccharomyces cerevisiae
    Zinc finger transcription factor involved in multidrug resistance; Zn(2)-Cys(6) zinc finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
  • KAP104
  • Saccharomyces cerevisiae
    Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis
  • SNU114
  • Saccharomyces cerevisiae
    GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
  • YJL206C
  • Saccharomyces cerevisiae
    Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment
  • CIN4
  • Saccharomyces cerevisiae
    GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
  • EMC2
  • Saccharomyces cerevisiae
    Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
  • PUP1
  • Saccharomyces cerevisiae
    Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
  • MRM2
  • Saccharomyces cerevisiae
    Mitochondrial 2' O-ribose methyltransferase; required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
  • ETR1
  • Saccharomyces cerevisiae
    2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to mitochondria, where it has a probable role in fatty acid synthesis; human MECR functionally complements the respiratory growth defect of the null mutant
  • CKB1
  • Saccharomyces cerevisiae
    Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
  • CKB2
  • Saccharomyces cerevisiae
    Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
  • API2
  • Saccharomyces cerevisiae
    Putative protein of unknown function; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology
  • GLC8
  • Saccharomyces cerevisiae
    Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress
  • TPP1
  • Saccharomyces cerevisiae
    DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3'-phosphatase
  • ECI1
  • Saccharomyces cerevisiae
    Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; ECI1 has a paralog, DCI1, that arose from the whole genome duplication
  • SWT1
  • Saccharomyces cerevisiae
    RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain
  • DPH1
  • Saccharomyces cerevisiae
    Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph2p that catalyzes the first step of diphthamide biosynthesis
  • DPH2
  • Saccharomyces cerevisiae
    Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph1p that catalyzes the first step of diphthamide biosynthesis
  • PAU21
  • Saccharomyces cerevisiae
    Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cytosol; identical to Pau22p; encodes two proteins that are translated from 2 different start codons
  • MF(ALPHA)1
  • Saccharomyces cerevisiae
    Alpha-factor mating pheromone made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions
  • PRM8
  • Saccharomyces cerevisiae
    Pheromone-regulated protein; contains with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family; PRM8 has a paralog, PRM9, that arose from a segmental duplication
  • TRM44
  • Saccharomyces cerevisiae
    tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
  • TUM1
  • Saccharomyces cerevisiae
    Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; involved in metabolism of sterol esters; may be mitochondrially localized
  • HGH1
  • Saccharomyces cerevisiae
    Chaperone protein for translation factor eEF2; involved in biogenesis of eukaryotic Elongation Factor 2 (Eft1p, Eft2p); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress
  • PPR1
  • Saccharomyces cerevisiae
    Zinc finger transcription factor; contains a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
  • CPD1
  • Saccharomyces cerevisiae
    Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress
  • SLM2
  • Saccharomyces cerevisiae
    Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
  • RNY1
  • Saccharomyces cerevisiae
    Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; required for tRNA-specific translational pausing during oxidative stress; promotes apoptosis under stress conditions and this function is independent of Rny1p catalytic activity
  • CUP2
  • Saccharomyces cerevisiae
    Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; required for regulation of copper genes in response to DNA-damaging reagents; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
  • COQ5
  • Saccharomyces cerevisiae
    2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; respiratory defect of the null mutant is partially complemented by human COQ5
  • LEU9
  • Saccharomyces cerevisiae
    Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication
  • SFI1
  • Saccharomyces cerevisiae
    Centrin (Cdc31p)-binding protein required for SPB duplication; localizes to the half-bridge of the spindle pole body (SPB); required for progression through G(2)-M transition; phosphorylated by Cdc28p-Clb2p and by Cdc5p; dephosphorylated by Cdc14p; has similarity to Xenopus laevis XCAP-C
  • CKA1
  • Saccharomyces cerevisiae
    Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching
  • COX1
  • Saccharomyces cerevisiae
    Subunit I of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; number of introns in different strains varies from 2 to 8, with most strains having 4-6 introns
  • OAF3
  • Saccharomyces cerevisiae
    Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
  • PDC2
  • Saccharomyces cerevisiae
    Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions
  • ZUO1
  • Saccharomyces cerevisiae
    Ribosome-associated chaperone; zuotin functions in ribosome biogenesis and as a chaperone for nascent polypeptide chains in partnership with Ssz1p and SSb1/2; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p; human gene DNAJC2 can partially complement yeast zuo1 null mutant
  • TIF5
  • Saccharomyces cerevisiae
    Translation initiation factor eIF5; functions as both a GTPase-activating protein (GAP) that stimulates the hydrolysis of GTP bound to eIF-2, as part of the 43S preinitiation complex, and as a GDP dissociation inhibitor (GDI) to prevent recycling of eIF2; human ortholog eIF5 complements the yeast null mutant
  • THP1
  • Saccharomyces cerevisiae
    Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
  • SWR1
  • Saccharomyces cerevisiae
    Swi2/Snf2-related ATPase; catalytic subunit of SWR1 complex, which exchanges histone variant H2A.Z (Htz1p) for chromatin-bound histone H2A; N-terminus can deliver H2A.Z-H2B dimer to DNA-(H3-H4)2 tetrasome; relocalizes to cytosol in response to hypoxia; chronological aging factor, mediates lifespan extension by dietary restriction
  • LPD1
  • Saccharomyces cerevisiae
    Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes; LPD1 has a paralog, IRC15, that arose from the whole genome duplication
  • RTT10
  • Saccharomyces cerevisiae
    WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6
  • HIT1
  • Saccharomyces cerevisiae
    Protein involved in C/D snoRNP assembly; critical for formation of small nucleolar ribonucleoprotein complexes that are required for rRNA processing and 2'-O-methylation; regulates abundance of Rsa1p; required for growth at high temperature; mutations in human homolog ZNHIT3 cause PEHO syndrome, a ribosomopathy characterized by extreme cerebellar atrophy
  • HST2
  • Saccharomyces cerevisiae
    Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export
  • SER3
  • Saccharomyces cerevisiae
    3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER3 has a paralog, SER33, that arose from the whole genome duplication
  • SER33
  • Saccharomyces cerevisiae
    3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER33 has a paralog, SER3, that arose from the whole genome duplication
  • VAC14
  • Saccharomyces cerevisiae
    Enzyme regulator; involved in synthesis of phosphatidylinositol 3,5-bisphosphate, in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; binds negative (Fig4p) and positive (Fab1p) regulators of PtdIns(3,5)P(2) to control endolysosome function; similar to mammalian Vac14p
  • SLM1
  • Saccharomyces cerevisiae
    Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
  • CDC34
  • Saccharomyces cerevisiae
    Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress; human CDC34 functionally complements the thermosensitivity of the cdc34-2 mutant
  • ENO1
  • Saccharomyces cerevisiae
    Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication
  • GIS2
  • Saccharomyces cerevisiae
    Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
  • ISC1
  • Saccharomyces cerevisiae
    Inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; regulates the spindle assembly checkpoint upstream of PP2A-Cdc55; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; mediates Na+ and Li+ halotolerance; activated by phosphatidylserine, cardiolipin and phosphatidylglycerol; mitochondrial outer membrane protein; ortholog of mammalian neutral sphingomyelinase type 2
  • SIC1
  • Saccharomyces cerevisiae
    Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
  • ENO2
  • Saccharomyces cerevisiae
    Enolase II, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; mRNA is asymmetrically distributed to daughter cells in a Sir2p-dependent manner, and asymmetry is lost during replicative aging; expression induced in response to glucose; ENO2 has a paralog, ENO1, that arose from the whole genome duplication
  • HXK2
  • Saccharomyces cerevisiae
    Hexokinase isoenzyme 2; phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose; represses expression of HXK1, GLK1, induces expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at Ser14 by kinase Snf1p, phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; functions downstream of Sit4p in control of cell cycle, mitochondrial function, oxidative stress resistance, chronological lifespan; has paralog HXK1
  • SAC3
  • Saccharomyces cerevisiae
    mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
  • PHO13
  • Saccharomyces cerevisiae
    Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphoglycolate and 4-phosphoerythronate; alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; human ortholog PGP shows similar substrate specificity, deletion causes similar metabolite accumulation phenotypes, suggesting conserved role in eliminating glycolytic byproducts
  • SUS1
  • Saccharomyces cerevisiae
    Global transcriptional regulator, component of SAGA, TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to nuclear periphery and to non-nascent mRNP; plays role in negatively regulating telomere length through modulation of H2BK123 mono-ubiquitination and its interaction with nuclear pore complex
  • YPR1
  • Saccharomyces cerevisiae
    NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant
  • CKA2
  • Saccharomyces cerevisiae
    Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
  • CWH43
  • Saccharomyces cerevisiae
    GPI lipid remodelase; responsible for introducing ceramides into GPI anchors having a C26:0 fatty acid in sn-2 of the glycerol moiety; can also use lyso-GPI protein anchors and various base resistant lipids as substrates; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
  • VPS53
  • Saccharomyces cerevisiae
    Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; required for vacuolar protein sorting; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; human ortholog is implicated in progressive cerebello-cerebral atrophy type 2 (PCCA2)
  • ECM22
  • Saccharomyces cerevisiae
    Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes upon sterol depletion, after relocating from intracellular membranes to perinuclear foci; redundant activator of filamentation with UPC2, up-regulating the expression of genes involved in filamentous growth; contains Zn[2]-Cys[6] binuclear cluster; ECM22 has a paralog, UPC2, that arose from the whole genome duplication
  • UGA3
  • Saccharomyces cerevisiae
    Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1, UGA2, and UGA4
  • CCC2
  • Saccharomyces cerevisiae
    Cu(+2)-transporting P-type ATPase; required for export of copper from cytosol into extracytosolic compartment; targeted to vacuole via AP-3 pathway; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant
  • PAH1
  • Saccharomyces cerevisiae
    Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; regulates phospholipid synthesis, nuclear/ER membrane growth, lipid droplet formation, triacylglycerol synthesis, vacuolar homeostasis and cell wall integrity; phosphorylated by Pho85p/Pho80p, Cdc28p/Cyclin B, PKA, PKC, and CKII, regulating activity, localization, and proteosomal degradation; homolog of mammalian lipins 1 and 2; human homologs LPIN1, LPIN2, LPIN3 complement the null
  • RAD4
  • Saccharomyces cerevisiae
    Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2; recognizes and binds damaged DNA with Rad23p during nucleotide excision repair (NER); also involved with Rad23p in turnover of ubiquitylated proteins; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage; RAD4 and RAD51 pathways confer resistance to benzo[a]pyrene dihydrodiol
  • RPD3
  • Saccharomyces cerevisiae
    Histone deacetylase, component of both Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the Hmt1p methyltransferase; delays late firing of single copy origins by opposing the Fkh1/2 origin activation pathway
  • ROD1
  • Saccharomyces cerevisiae
    Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication
  • MOD5
  • Saccharomyces cerevisiae
    Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; also has a role in tRNA gene-mediated silencing; gene encodes two isozymic forms; converts to a prion form, prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis; homolog of human TRIT1, a mutation in which is associated with severe combined respiratory chain defects
  • SAC6
  • Saccharomyces cerevisiae
    Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant
  • COQ8
  • Saccharomyces cerevisiae
    ATPase required for ubiquinone biosynthesis and respiratory growth; maintains levels of CoQ biosynthetic proteins; binds to CoQ biosynthesis intermediates; UbiB protein kinase-like family member that lacks canonical protein kinase activity; similar to prokaryotic proteins involved in ubiquinone biosynthesis; human homolog ADCK3 complements a coq8 null, is associated with CoQ and respiratory-chain deficiencies, and is mutated in autosomal-recessive cerebellar ataxia type 2
  • TDH2
  • Saccharomyces cerevisiae
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides are active against a wide variety of wine-related yeasts and bateria; TDH2 has a paralog, TDH3, that arose from the whole genome duplication
  • MAF1
  • Saccharomyces cerevisiae
    Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase 2; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions
  • FAR11
  • Saccharomyces cerevisiae
    Protein involved in recovery from cell cycle arrest; acts in response to pheromone; also involved in regulation of intra-S DNA damage checkpoint and autophagy; is essential for dephosphorylation of Atg13p; interacts with Far3p, Far7p, Far8p, Far9p, Far10p and with the phosphatases Pph21p, Pph22p and Pph3p; has similarity to the N- and C-termini of N. crassa HAM-2; similar to human Fam40A and Fam40B
  • LDB19
  • Saccharomyces cerevisiae
    Alpha-arrestin, Ub-ligase adaptor for Rsp5p; regulates starvation- and substrate-induced Ub-dependent endocytosis of select plasma membrane localized amino acid transporters, recruiting Rsp5p to its targets; role in basal internalization and turnover of Ste2p, mating and zygote formation; recruits Rsp5p to Ste2p via its 2 PPXY motifs; inhibited by Npr1p-mediated phosphorylation, affecting cytosol and plasma membrane translocation; localization regulated by Rsp5p-dependent ubiquitination
  • PUT3
  • Saccharomyces cerevisiae
    Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
  • SEM1
  • Saccharomyces cerevisiae
    19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress
  • UPC2
  • Saccharomyces cerevisiae
    Sterol regulatory element binding protein; induces sterol biosynthetic genes, upon sterol depletion; acts as a sterol sensor, binding ergosterol in sterol rich conditions; relocates from intracellular membranes to perinuclear foci upon sterol depletion; redundant activator of filamentation with ECM22, up-regulating the expression of filamentous growth genes; contains a Zn[2]-Cys[6] binuclear cluster; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
  • SEN1
  • Saccharomyces cerevisiae
    ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS
  • USB1
  • Saccharomyces cerevisiae
    Putative poly(U)-specific 3'-to-5' RNA exonuclease; involved in 3'-end processing of U6 snRNA removing uridines and generating a terminal 2′,3′ cyclic phosphate; essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants; homolog of S.pombe gene, mpn1 and human gene, hUSB1; mutations in hUSB1 are associated with a rare genodermatosis, poikiloderma with neutropenia (OMIM 604173)
  • POG1
  • Saccharomyces cerevisiae
    DNA-binding transcriptional activator; involved in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest via CLN1/2 transcription, induction of of IME1 during sporulation, and suppression of stress sensitivity resulting from mutation of the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; phosphorylated form may be ubiquitinated by Dma2p; potential Cdc28p substrate; regulated by Swi4/6 cell-cycle box binding factor (SBF)
  • RAD23
  • Saccharomyces cerevisiae
    Proteasome-associated ubiquitin receptor; K48-specific Ub chain binding protein that recruits substrates to the proteasome; subunit of nuclear excision repair factor 2 (NER2) with Rad4p that binds damaged DNA during NER, linking repair to proteolysis; NER2 binds DDR gene promoters to repress transcription in the absence of damage; stimulates Png1p-induced protein deglycosylation; contains a Ub-like (UBL) and two Ub-associated (UBA) domains; UBA2 protects Rad23p from proteasomal degradation
  • TPA1
  • Saccharomyces cerevisiae
    Prolyl hydroxylase; catalyzes oxygen-dependent dihydroxylation of Rps23a/b, a 40S ribosomal decoding center subunit; influences translational termination and regulates translational accuracy; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; disputed role as a oxidative dealkylase repairing DNA methyl-base lesions; poly(rA)-binding protein affecting poly(A) tail length and mRNA stability; Fe(II)/2-oxoglutarate-dependent dioxygenase family member similar to human prolyl 4-hydroxylase OGFOD1
  • ASP3-4
  • Saccharomyces cerevisiae
    Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-4 has a paralog, ASP3-2, that arose from a segmental duplication
  • HSC82
  • Saccharomyces cerevisiae
    Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication
  • MYO5
  • Saccharomyces cerevisiae
    One of two type I myosin motors; involved in clathrin-mediated endocytosis; activation by TEDS site phosphorylation increases actin gliding, motor activity and ligand-induced endocytosis; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication
  • YPK1
  • Saccharomyces cerevisiae
    S/T protein kinase; required for PM lipid and protein homeostasis; involved in sphingolipid-mediated and cell integrity signaling pathways and endocytosis; phosphorylates and downregulates Fpk1p; phosphorylates and inactivates Orm1p/2p when sphingolipid synthesis is compromised; role in TORC1/2-dependent Rps6a/b phosphorylation; phosphorylated and activated by TORC2 and by Pkh1/2p in the presence of phytosphingosine; human homolog SGK1 complements the null and inviability of a ypk1 ypk2 mutant
  • ASP3-2
  • Saccharomyces cerevisiae
    Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-2 has a paralog, ASP3-4, that arose from a segmental duplication
  • BXI1
  • Saccharomyces cerevisiae
    Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
  • IRC20
  • Saccharomyces cerevisiae
    E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent NHEJ pathway; controls 2-micron plasmid copy number by regulating the levels of the Flp1p recombinase; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; null mutant displays increased levels of spontaneous Rad52p foci
  • STU1
  • Saccharomyces cerevisiae
    Microtubule plus-end-tracking non-motor protein; binds to MTs, stabilizing interpolar MT plus ends, facilitating polymerization of spindle MTs and producing an outward force on spindle poles; required for structural integrity of the mitotic spindle; binds detached kinetochores (KTs) and promotes capture; relocalizes to MTs and stabilizes the spindle once captured KTs reach a spindle pole; localizes to the spindle, spindles poles, and detached KTs; CLASP family member homologous to human CLASP1/2
  • ENSEMBL:ENSP00000436283
  • Homo sapiens
    Isoform 2 of 2-acylglycerol O-acyltransferase 2
  • ENSEMBL:ENSP00000394239
  • Homo sapiens
    Isoform 2 of NEDD4-binding protein 2-like 2
  • ENSEMBL:ENSP00000327694
  • Homo sapiens
    Isoform 2 of AP-2 complex subunit alpha-2
  • ENSEMBL:ENSP00000367635
  • Homo sapiens
    Isoform 2 of Cytoplasmic tRNA 2-thiolation protein 2
  • SW:Q9NYQ2
  • Mus musculus
    2-Hydroxyacid oxidase 2
  • SW:Q3ZBW2
  • Bos taurus
    2-Hydroxyacid oxidase 2
  • ENSEMBL:ENSP00000373905
  • Homo sapiens
    dynamin-2 isoform 2
  • SW:A3LQI7
  • Scheffersomyces stipitis
    Leucine aminopeptidase 2-2
  • ENSEMBL:ENSP00000403737
  • Homo sapiens
    presenilin-2 isoform 2
  • ENSEMBL:ENSP00000356079
  • Homo sapiens
    synaptojanin-2 isoform 2
  • SW:Q07523
  • Rattus norvegicus
    2-Hydroxyacid oxidase 2
  • SW:A5DGF3
  • Meyerozyma guilliermondii
    Leucine aminopeptidase 2-2
  • ENSEMBL:ENSP00000344177
  • Homo sapiens
    Isoform 2 of Polycystic kidney disease 2-like 2 protein
  • ENSEMBL:ENSP00000380253
  • Homo sapiens
    Isoform 2 of Nuclear factor erythroid 2-related factor 2
  • ENSEMBL:ENSP00000355569
  • Homo sapiens
    Isoform 2 of Interferon regulatory factor 2-binding protein 2
  • ENSEMBL:ENSP00000436988
  • Homo sapiens
    Isoform 2 of POU domain, class 2, transcription factor 2
  • ENSEMBL:ENSP00000282903
  • Homo sapiens
    Isoform 2 of Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  • ENSEMBL:ENSP00000221504
  • Homo sapiens
    Isoform 2 of N(2),N(2)-dimethylguanosine tRNA methyltransferase
  • ENSEMBL:ENSP00000320447
  • Homo sapiens
    Isoform 2 of Nuclear receptor subfamily 2 group C member 2
  • ENSEMBL:ENSP00000356046
  • Homo sapiens
    Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
  • ENSEMBL:ENSP00000376128
  • Homo sapiens
    Isoform 2 of Tomoregulin-2
  • SW:Q9JLG4
  • Mus musculus
    Polycystin-2-like protein 2
  • SW:Q6NV04
  • Danio rerio
    2-hydroxyacyl-CoA lyase 2
  • SW:Q8BU33
  • Mus musculus
    2-hydroxyacyl-CoA lyase 2
  • ENSEMBL:ENSP00000378044
  • Homo sapiens
    Isoform 2 of Ankyrin-2
  • SW:A2QX45
  • Aspergillus niger
    Dicer-like protein 2-2
  • SW:P37552
  • Bacillus subtilis
    2-iminobutanoate/2-iminopropanoate deaminase
  • ENSEMBL:ENSP00000443730
  • Homo sapiens
    Isoform 2 of Nidogen-2
  • ENSEMBL:ENSP00000354561
  • Homo sapiens
    Isoform 2 of Intersectin-2
  • ENSEMBL:ENSP00000365733
  • Homo sapiens
    Isoform 2 of Xylosyltransferase 2
  • ENSEMBL:ENSP00000404590
  • Homo sapiens
    Isoform 2 of Tropomodulin-2
  • SW:P70345
  • Mus musculus
    Bcl-2-like protein 2
  • SW:Q45T69
  • Canis lupus familiaris
    Bcl-2-like protein 2
  • ENSEMBL:ENSP00000439048
  • Homo sapiens
    serine incorporator 2 isoform 2
  • ENSEMBL:ENSP00000384169
  • Homo sapiens
    Isoform 2 of Fibulin-2
  • ENSEMBL:ENSP00000284027
  • Homo sapiens
    Isoform 2 of Mucolipin-2
  • ENSEMBL:ENSP00000305223
  • Homo sapiens
    Isoform 2 of Calcipressin-2
  • ENSEMBL:ENSP00000408236
  • Homo sapiens
    Isoform 2 of Cytohesin-2
  • ENSEMBL:ENSP00000298892
  • Homo sapiens
    Isoform 2 of Caprin-2
  • SW:O81850
  • Arabidopsis thaliana
    Fe(2+) transport protein 2
  • SW:Q51948
  • Pseudomonas putida
    2-hydroxychromene-2-carboxylate isomerase
  • SW:Q9X9Q7
  • Sphingobium xenophagum
    2-hydroxychromene-2-carboxylate isomerase
  • ENSEMBL:ENSP00000350719
  • Homo sapiens
    Isoform 2 of Nesprin-2
  • ENSEMBL:ENSP00000291741
  • Homo sapiens
    Isoform 2 of Ficolin-2
  • ENSEMBL:ENSP00000322270
  • Homo sapiens
    Isoform 2 of Latrophilin-2
  • ENSEMBL:ENSP00000341895
  • Homo sapiens
    beta-arrestin-2 isoform 2
  • ENSEMBL:ENSP00000365515
  • Homo sapiens
    Isoform 2 of Mitofusin-2
  • SW:F4KIN4
  • Arabidopsis thaliana
    Putative 2-dehydropantoate 2-reductase
  • SW:Q54VQ7
  • Dictyostelium discoideum
    Type-2 histone deacetylase 2
  • ENSEMBL:ENSP00000320168
  • Homo sapiens
    Isoform 2 of Nucleobindin-2
  • ENSEMBL:ENSP00000347890
  • Homo sapiens
    Isoform 2 of Dynamin-2
  • ENSEMBL:ENSP00000288561
  • Homo sapiens
    Isoform 2 of Ubinuclein-2
  • ENSEMBL:ENSP00000415336
  • Homo sapiens
    Isoform 2 of Atlastin-2
  • ENSEMBL:ENSP00000250405
  • Homo sapiens
    Bcl-2-like protein 2
  • ENSEMBL:ENSP00000344590
  • Homo sapiens
    Isoform 2 of Junctophilin-2
  • ENSEMBL:ENSP00000325379
  • Homo sapiens
    Isoform 2 of Rhotekin-2
  • SW:Q6DDK5
  • Xenopus laevis
    2-hydroxyacyl-CoA lyase 2
  • ENSEMBL:ENSP00000399102
  • Homo sapiens
    Isoform 2 of Mitoferrin-2
  • SW:Q7CP78
  • Salmonella typhimurium
    2-iminobutanoate/2-iminopropanoate deaminase
  • ENSEMBL:ENSP00000442542
  • Homo sapiens
    Isoform 2 of Prominin-2
  • ENSEMBL:ENSP00000446576
  • Homo sapiens
    Isoform 2 of Ataxin-2
  • SW:B9DHD7
  • Arabidopsis thaliana
    Vesicle-associated protein 2-2
  • SW:Q1RMX3
  • Bos taurus
    Bcl-2-like protein 2
  • ENSEMBL:ENSP00000356633
  • Homo sapiens
    Isoform 2 of Pappalysin-2
  • ENSEMBL:ENSP00000376963
  • Homo sapiens
    Isoform 2 of Calcyphosin-2
  • ENSEMBL:ENSP00000335220
  • Homo sapiens
    Isoform 2 of Erlin-2
  • SW:Q5M8H5
  • Xenopus tropicalis
    2-acylglycerol O-acyltransferase 2
  • SW:Q52462
  • Pseudomonas sp
    2-hydroxychromene-2-carboxylate isomerase
  • ENSEMBL:ENSP00000429977
  • Homo sapiens
    Isoform 2 of Matrilin-2
  • SW:A6QQT9
  • Bos taurus
    2-hydroxyacyl-CoA lyase 2
  • ENSEMBL:ENSP00000406963
  • Homo sapiens
    Isoform 2 of Caskin-2
  • SW:Q8U308
  • Pyrococcus furiosus
    2-iminobutanoate/2-iminopropanoate deaminase
  • ENSEMBL:ENSP00000320204
  • Homo sapiens
    Isoform 2 of Insulin-like growth factor 2 mRNA-binding protein 2
  • ENSEMBL:ENSP00000390329
  • Homo sapiens
    Isoform 2 of Voltage-dependent calcium channel subunit alpha-2/delta-2
  • ENSEMBL:ENSP00000388565
  • Homo sapiens
    lipid phosphate phosphohydrolase 2 isoform 2
  • SW:Q2KHS5
  • Xenopus laevis
    2-acylglycerol O-acyltransferase 2-A
  • ENSEMBL:ENSP00000400371
  • Homo sapiens
    Isoform 2 of Protein sidekick-2
  • SW:Q8LPK4
  • Arabidopsis thaliana
    AP-2 complex subunit alpha-2
  • ENSEMBL:ENSP00000445571
  • Homo sapiens
    chondroitin sulfate synthase 2 isoform 2
  • ENSEMBL:ENSP00000376571
  • Homo sapiens
    anion exchange protein 2 isoform 2
  • ENSEMBL:ENSP00000430176
  • Homo sapiens
    Isoform 2 of Protein argonaute-2
  • ENSEMBL:ENSP00000326746
  • Homo sapiens
    Isoform 2 of Pumilio homolog 2
  • ENSEMBL:ENSP00000385020
  • Homo sapiens
    Isoform 2 of Gamma-2-syntrophin
  • ENSEMBL:ENSP00000230640
  • Homo sapiens
    Superkiller viralicidic activity 2-like 2
  • ENSEMBL:ENSP00000404622
  • Homo sapiens
    serum paraoxonase/arylesterase 2 isoform 2
  • ENSEMBL:ENSP00000405844
  • Homo sapiens
    Isoform 2 of Asialoglycoprotein receptor 2
  • SW:Q9MAU6
  • Arabidopsis thaliana
    Protein disulfide-isomerase like 2-2
  • ENSEMBL:ENSP00000376406
  • Homo sapiens
    Isoform 2 of Inverted formin-2
  • SW:Q66H65
  • Rattus norvegicus
    NEDD4-binding protein 2-like 2
  • SW:Q8JZS6
  • Mus musculus
    NEDD4-binding protein 2-like 2
  • ENSEMBL:ENSP00000424198
  • Homo sapiens
    kelch-like protein 2 isoform 2
  • SW:O14157
  • Schizosaccharomyces pombe
    Myosin type-2 heavy chain 2
  • ENSEMBL:ENSP00000243067
  • Homo sapiens
    cyclin-dependent kinase 2 isoform 2
  • ENSEMBL:ENSP00000377630
  • Homo sapiens
    kinesin light chain 2 isoform 2
  • ENSEMBL:ENSP00000413804
  • Homo sapiens
    Isoform 2 of Alanine aminotransferase 2
  • ENSEMBL:ENSP00000403205
  • Homo sapiens
    Isoform 2 of Phosphatidate cytidylyltransferase 2
  • ENSEMBL:ENSP00000373996
  • Homo sapiens
    Isoform 2 of ERI1 exoribonuclease 2
  • ENSEMBL:ENSP00000352092
  • Homo sapiens
    Isoform 2 of Putative adenosylhomocysteinase 2
  • ENSEMBL:ENSP00000437458
  • Homo sapiens
    neuroendocrine convertase 2 isoform 2 preproprotein
  • SW:P18484
  • Rattus norvegicus
    AP-2 complex subunit alpha-2
  • SW:Q86KI1
  • Dictyostelium discoideum
    AP-2 complex subunit alpha-2
  • ENSEMBL:ENSP00000343737
  • Homo sapiens
    myotubularin-related protein 2 isoform 2
  • ENSEMBL:ENSP00000331851
  • Homo sapiens
    Isoform 2 of Nodal modulator 2
  • ENSEMBL:ENSP00000408910
  • Homo sapiens
    Isoform 2 of Dynactin subunit 2
  • ENSEMBL:ENSP00000363394
  • Homo sapiens
    Isoform 2 of Zinc transporter 2
  • ENSEMBL:ENSP00000367372
  • Homo sapiens
    Isoform 2 of Protocadherin alpha-2
  • ENSEMBL:ENSP00000342858
  • Homo sapiens
    fermitin family homolog 2 isoform 2
  • ENSEMBL:ENSP00000435409
  • Homo sapiens
    CAAX prenyl protease 2 isoform 2
  • ENSEMBL:ENSP00000418191
  • Homo sapiens
    Isoform 2 of Catenin alpha-2
  • SW:Q5M7F4
  • Xenopus laevis
    2-acylglycerol O-acyltransferase 2-B
  • ENSEMBL:ENSP00000399949
  • Homo sapiens
    calpain-2 catalytic subunit isoform 2
  • ENSEMBL:ENSP00000418344
  • Homo sapiens
    Isoform 2 of Roundabout homolog 2
  • SW:Q5U4F6
  • Mus musculus
    Cytoplasmic dynein 2 intermediate chain 2
  • ENSEMBL:ENSP00000261017
  • Homo sapiens
    Isoform 2 of Abl interactor 2
  • ENSEMBL:ENSP00000353174
  • Homo sapiens
    Isoform 2 of Ryanodine receptor 2
  • ENSEMBL:ENSP00000362223
  • Homo sapiens
    Isoform 2 of Dachshund homolog 2
  • SW:Q94AH9
  • Arabidopsis thaliana
    rRNA 2'-O-methyltransferase fibrillarin 2
  • ENSEMBL:ENSP00000389477
  • Homo sapiens
    Isoform 2 of Protein dopey-2
  • ENSEMBL:ENSP00000451873
  • Homo sapiens
    mitochondrial 2-oxodicarboxylate carrier isoform 2
  • ENSEMBL:ENSP00000406855
  • Homo sapiens
    protein NipSnap homolog 2 isoform 2
  • SW:Q0VCK5
  • Bos taurus
    AP-2 complex subunit alpha-2
  • SW:P17427
  • Mus musculus
    AP-2 complex subunit alpha-2
  • ENSEMBL:ENSP00000359696
  • Homo sapiens
    Isoform 2 of Deoxyribonuclease-2-beta
  • ENSEMBL:ENSP00000371370
  • Homo sapiens
    Isoform 2 of Riboflavin transporter 2
  • ENSEMBL:ENSP00000370898
  • Homo sapiens
    Isoform 2 of Beta-arrestin-2
  • ENSEMBL:ENSP00000251527
  • Homo sapiens
    Isoform 2 of Extended synaptotagmin-2
  • ENSEMBL:ENSP00000392859
  • Homo sapiens
    Isoform 2 of GMP reductase 2
  • ENSEMBL:ENSP00000356410
  • Homo sapiens
    Isoform 2 of Glutaredoxin-2, mitochondrial
  • ENSEMBL:ENSP00000385186
  • Homo sapiens
    SEC14-like protein 2 isoform 2
  • SW:Q942L2
  • Oryza sativa subsp japonica
    Protein disulfide isomerase-like 2-2
  • ENSEMBL:ENSP00000443283
  • Homo sapiens
    hyaluronan-binding protein 2 isoform 2
  • ENSEMBL:ENSP00000395616
  • Homo sapiens
    glucosidase 2 subunit beta isoform 2
  • ENSEMBL:ENSP00000352661
  • Homo sapiens
    Isoform 2 of Catenin delta-2
  • ENSEMBL:ENSP00000345508
  • Homo sapiens
    Isoform 2 of Disabled homolog 2
  • ENSEMBL:ENSP00000379394
  • Homo sapiens
    Isoform 2 of Neuron navigator 2
  • ENSEMBL:ENSP00000353092
  • Homo sapiens
    Isoform 2 of Crumbs homolog 2
  • ENSEMBL:ENSP00000356169
  • Homo sapiens
    Isoform 2 of Ethanolamine kinase 2
  • ENSEMBL:ENSP00000309623
  • Homo sapiens
    Isoform 2 of Retinal dehydrogenase 2
  • SW:P86785
  • Crassostrea gigas
    Gigasin-2 {ECO:0000303|Ref.2}
  • ENSEMBL:ENSP00000421704
  • Homo sapiens
    LEM domain-containing protein 2 isoform 2
  • SW:P54665
  • Trypanosoma brucei brucei
    Cell division control protein 2 homolog 2
  • ENSEMBL:ENSP00000389703
  • Homo sapiens
    Isoform 2 of Protein patched homolog 2
  • ENSEMBL:ENSP00000388084
  • Homo sapiens
    2-oxoglutarate dehydrogenase, mitochondrial isoform 2 precursor
  • ENSEMBL:ENSP00000409471
  • Homo sapiens
    Isoform 2 of Syntaxin-binding protein 2
  • ENSEMBL:ENSP00000446313
  • Homo sapiens
    DNA polymerase epsilon subunit 2 isoform 2
  • ENSEMBL:ENSP00000264827
  • Homo sapiens
    Isoform 2 of Protein Hook homolog 2
  • ENSEMBL:ENSP00000407634
  • Homo sapiens
    Isoform 2 of Homer protein homolog 2
  • ENSEMBL:ENSP00000449475
  • Homo sapiens
    Isoform 2 of Protein DDI1 homolog 2
  • SW:Q7ZXS3
  • Xenopus laevis
    Interferon regulatory factor 2-binding protein 2
  • ENSEMBL:ENSP00000419339
  • Homo sapiens
    Isoform 2 of RING-box protein 2
  • SW:Q94AL9
  • Arabidopsis thaliana
    Alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial
  • ENSEMBL:ENSP00000421849
  • Homo sapiens
    Isoform 2 of Endoplasmic reticulum aminopeptidase 2
  • ENSEMBL:ENSP00000349996
  • Homo sapiens
    Isoform 2 of Inorganic pyrophosphatase 2, mitochondrial
  • ENSEMBL:ENSP00000371608
  • Homo sapiens
    Isoform 2 of Slit homolog 2 protein
  • ENSEMBL:ENSP00000294868
  • Homo sapiens
    Isoform 2 of Nicotinamide mononucleotide adenylyltransferase 2
  • ENSEMBL:ENSP00000267836
  • Homo sapiens
    Isoform 2 of Myelin expression factor 2
  • ENSEMBL:ENSP00000342559
  • Homo sapiens
    Isoform 2 of Copper-transporting ATPase 2
  • SW:Q58CN7
  • Bos taurus
    Cyclin-dependent kinase 2-associated protein 2
  • ENSEMBL:ENSP00000338352
  • Homo sapiens
    Isoform 2 of Diphosphoinositol polyphosphate phosphohydrolase 2
  • ENSEMBL:ENSP00000007708
  • Homo sapiens
    pyruvate dehydrogenase kinase, isozyme 2 isoform 2
  • ENSEMBL:ENSP00000267287
  • Homo sapiens
    Isoform 2 of Muscleblind-like protein 2
  • ENSEMBL:ENSP00000365015
  • Homo sapiens
    Isoform 2 of Nucleoredoxin-like protein 2
  • SW:Q400K3
  • Pseudomonas putida
    2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase 2 {ECO:0000255|HAMAP-Rule:MF_01654}
  • ENSEMBL:ENSP00000382403
  • Homo sapiens
    Isoform 2 of Tau-tubulin kinase 2
  • ENSEMBL:ENSP00000382243
  • Homo sapiens
    Isoform 2 of Fermitin family homolog 2
  • SW:Q29013
  • Sus scrofa
    POU domain, class 2, transcription factor 2
  • SW:P28567
  • Pisum sativum
    Cell division control protein 2 homolog 2
  • ENSEMBL:ENSP00000425770
  • Homo sapiens
    Isoform 2 of mRNA-decapping enzyme 2
  • HI:HIT000435470
  • Homo sapiens
    Isoform 2 of Pantothenate kinase 2, mitochondrial
  • ENSEMBL:ENSP00000439256
  • Homo sapiens
    Isoform 2 of YY1-associated factor 2
  • ENSEMBL:ENSP00000439662
  • Homo sapiens
    Isoform 2 of Clathrin heavy chain 2
  • SW:A9ALD3
  • Burkholderia multivorans
    Delta(1)-pyrroline-2-carboxylate reductase 2
  • SW:P41035
  • Oryctolagus cuniculus
    Eukaryotic translation initiation factor 2 subunit 2
  • ENSEMBL:ENSP00000443800
  • Homo sapiens
    Isoform 2 of Elongator complex protein 2
  • SW:Q9CPY4
  • Mus musculus
    Cyclin-dependent kinase 2-associated protein 2
  • ENSEMBL:ENSP00000364119
  • Homo sapiens
    Eukaryotic translation initiation factor 2 subunit 2
  • ENSEMBL:ENSP00000269399
  • Homo sapiens
    Isoform 2 of Chromobox protein homolog 2
  • ENSEMBL:ENSP00000249883
  • Homo sapiens
    Isoform 2 of Angiomotin-like protein 2
  • ENSEMBL:ENSP00000345143
  • Homo sapiens
    Isoform 2 of Smoothelin-like protein 2
  • SW:Q9R0B9
  • Mus musculus
    Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  • SW:Q811A3
  • Rattus norvegicus
    Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
  • ENSEMBL:ENSP00000387533
  • Homo sapiens
    Isoform 2 of CWF19-like protein 2
  • ENSEMBL:ENSP00000407468
  • Homo sapiens
    Isoform 2 of Beta-1,4-galactosyltransferase 2
  • SW:Q05006
  • Medicago sativa
    Cell division control protein 2 homolog 2
  • SW:Q5E9D0
  • Bos taurus
    Eukaryotic translation initiation factor 2 subunit 2
  • SW:Q54T27
  • Dictyostelium discoideum
    Eukaryotic translation initiation factor 2 subunit 2
  • ENSEMBL:ENSP00000430278
  • Homo sapiens
    betaine--homocysteine S-methyltransferase 2 isoform 2
  • ENSEMBL:ENSP00000406699
  • Homo sapiens
    Isoform 2 of Transcriptional adapter 2-alpha
  • ENSEMBL:ENSP00000437637
  • Homo sapiens
    Isoform 2 of Tyrosyl-DNA phosphodiesterase 2
  • ENSEMBL:ENSP00000216080
  • Homo sapiens
    Isoform 2 of Lipase maturation factor 2
  • ENSEMBL:ENSP00000362140
  • Homo sapiens
    Isoform 2 of Protein diaphanous homolog 2
  • ENSEMBL:ENSP00000278597
  • Homo sapiens
    Isoform 2 of D(2) dopamine receptor
  • ENSEMBL:ENSP00000353696
  • Homo sapiens
    Isoform 2 of Protein angel homolog 2
  • ENSEMBL:ENSP00000374655
  • Homo sapiens
    Isoform 2 of DIS3-like exonuclease 2
  • ENSEMBL:ENSP00000413548
  • Homo sapiens
    Isoform 2 of 5'-3' exoribonuclease 2
  • ENSEMBL:ENSP00000218089
  • Homo sapiens
    Isoform 2 of Cohesin subunit SA-2
  • ENSEMBL:ENSP00000390127
  • Homo sapiens
    Isoform 2 of Storkhead-box protein 2
  • ENSEMBL:ENSP00000304893
  • Homo sapiens
    Isoform 2 of GTP-binding protein 2
  • ENSEMBL:ENSP00000423947
  • Homo sapiens
    Isoform 2 of Transcriptional adapter 2-beta
  • HI:HIT000386949
  • Homo sapiens
    Isoform 2 of Indoleamine 2,3-dioxygenase 2
  • ENSEMBL:ENSP00000428267
  • Homo sapiens
    Isoform 2 of Piwi-like protein 2
  • ENSEMBL:ENSP00000390986
  • Homo sapiens
    glutathione S-transferase omega-2 isoform 2
  • SW:Q5R4T9
  • Pongo abelii
    Eukaryotic translation initiation factor 2 subunit 2
  • ENSEMBL:ENSP00000401485
  • Homo sapiens
    Isoform 2 of Prospero homeobox protein 2
  • ENSEMBL:ENSP00000379947
  • Homo sapiens
    Isoform 2 of Epidermal retinol dehydrogenase 2
  • ENSEMBL:ENSP00000381504
  • Homo sapiens
    Isoform 2 of Ribose-phosphate pyrophosphokinase 2
  • ENSEMBL:ENSP00000223951
  • Homo sapiens
    Isoform 2 of ELAV-like protein 2
  • ENSEMBL:ENSP00000365438
  • Homo sapiens
    Isoform 2 of Diacylglycerol O-acyltransferase 2
  • ENSEMBL:ENSP00000311833
  • Homo sapiens
    Isoform 2 of Sugar phosphate exchanger 2
  • ENSEMBL:ENSP00000329697
  • Homo sapiens
    Isoform 2 of Lipid phosphate phosphohydrolase 2
  • ENSEMBL:ENSP00000374410
  • Homo sapiens
    Isoform 2 of Inactive rhomboid protein 2
  • ENSEMBL:ENSP00000342944
  • Homo sapiens
    Isoform 2 of DNA topoisomerase 2-alpha
  • ENSEMBL:ENSP00000257261
  • Homo sapiens
    Isoform 2 of Fatty acid desaturase 2
  • ENSEMBL:ENSP00000312860
  • Homo sapiens
    Isoform 2 of TOM1-like protein 2
  • ENSEMBL:ENSP00000368651
  • Homo sapiens
    Isoform 2 of Folliculin-interacting protein 2
  • ENSEMBL:ENSP00000362548
  • Homo sapiens
    Isoform 2 of Adenylate kinase 2, mitochondrial
  • ENSEMBL:ENSP00000439159
  • Homo sapiens
    Isoform 2 of RIMS-binding protein 2
  • SW:Q84JL2
  • Arabidopsis thaliana
    2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial
  • ENSEMBL:ENSP00000301488
  • Homo sapiens
    Cyclin-dependent kinase 2-associated protein 2
  • SW:P80384
  • Lepidoglyphus destructor
    Mite group 2 allergen Lep d 2
  • SW:Q965E2
  • Psoroptes ovis
    Mite group 2 allergen Pso o 2
  • SW:E9Q1P8
  • Mus musculus
    Interferon regulatory factor 2-binding protein 2
  • SW:Q6DIH5
  • Xenopus tropicalis
    Interferon regulatory factor 2-binding protein 2
  • SW:Q9SN90
  • Arabidopsis thaliana
    Structural maintenance of chromosomes protein 2-2
  • ENSEMBL:ENSP00000402524
  • Homo sapiens
    programmed cell death protein 2 isoform 2
  • ENSEMBL:ENSP00000416883
  • Homo sapiens
    glutathione S-transferase Mu 2 isoform 2
  • ENSEMBL:ENSP00000378702
  • Homo sapiens
    Isoform 2 of Bromodomain-containing protein 2
  • SW:Q9LDY2
  • Arabidopsis thaliana
    2-oxoisovalerate dehydrogenase subunit beta 2, mitochondrial
  • ENSEMBL:ENSP00000365272
  • Homo sapiens
    Isoform 2 of Disks large homolog 2
  • ENSEMBL:ENSP00000373992
  • Homo sapiens
    POU domain, class 2, transcription factor 2
  • ENSEMBL:ENSP00000364034
  • Homo sapiens
    Isoform 2 of Antigen peptide transporter 2
  • ENSEMBL:ENSP00000317385
  • Homo sapiens
    Isoform 2 of GLIPR1-like protein 2
  • ENSEMBL:ENSP00000364548
  • Homo sapiens
    Isoform 2 of DCN1-like protein 2
  • ENSEMBL:ENSP00000324364
  • Homo sapiens
    Isoform 2 of CLIP-associating protein 2
  • ENSEMBL:ENSP00000380446
  • Homo sapiens
    Isoform 2 of Polyadenylate-binding protein 2
  • SW:Q99L45
  • Mus musculus
    Eukaryotic translation initiation factor 2 subunit 2
  • ENSEMBL:ENSP00000418442
  • Homo sapiens
    Isoform 2 of Extracellular sulfatase Sulf-2
  • ENSEMBL:ENSP00000449444
  • Homo sapiens
    Isoform 2 of Protein canopy homolog 2
  • ENSEMBL:ENSP00000323763
  • Homo sapiens
    Isoform 2 of FGFR1 oncogene partner 2
  • ENSEMBL:ENSP00000435162
  • Homo sapiens
    Isoform 2 of Mpv17-like protein 2
  • ENSEMBL:ENSP00000351599
  • Homo sapiens
    Isoform 2 of Neuropeptide FF receptor 2