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serine, L-allo-threonine, and other 3-hydroxy acids; catalyzes the reduction of (S)-alpha-acetolactate to 2,3-dimethylglycerate; short-chain dehydrogenase/reductase (SDR) family member; GFP fusion protein localizes to the cytoplasm and nucleus","page_type":"protein","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"label":"ORA1","wbid":"SGD:YMR226C","name":{"id":"SGD:YMR226C","taxonomy":"s_cerevisiae","label":"ORA1","highlight":{"description_all":["-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-"]},"other_names":null,"class":"protein"}},{"page_type":"protein","description":"PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that 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vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress"},{"wbid":"SGD:YKR084C","name":{"highlight":{"description_all":["ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, particularly in 3'"]},"taxonomy":"s_cerevisiae","id":"SGD:YKR084C","label":"HBS1","class":"protein","other_names":null},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"HBS1","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"description":"GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, particularly in 3' UTRs; genetically implicated in mRNA no-go decay; HBS1 has a 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pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs; binds junction of ITS2 and ITS2-proximal stem between the 3' end of 5.8S rRNA and the 5' end of 25S rRNA","wbid":"SGD:YNL002C","name":{"label":"RLP7","taxonomy":"s_cerevisiae","id":"SGD:YNL002C","highlight":{"description_all":["precursors to the large ribosomal subunit RNAs; binds junction of ITS2 and ITS2-proximal stem between the 3'"]},"other_names":null,"class":"protein"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"label":"RLP7"},{"page_type":"protein","description":"Subunit of EGO/GSE complex; vacuolar/endosomal membrane-associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from endosome to plasma membrane; essential for integrity and function of EGO; targeted to vacuole via AP-3 pathway; gene exhibits synthetic genetic interaction with MSS4","wbid":"SGD:YBR077C","name":{"class":"protein","other_names":null,"highlight":{"description_all":["endosome to plasma membrane; essential for integrity and function of EGO; targeted to vacuole via AP-3"]},"taxonomy":"s_cerevisiae","id":"SGD:YBR077C","label":"SLM4"},"taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"label":"SLM4"},{"description":"Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; human homolog EXOSC1 partially complements yeast csl4 null mutant, and can complement inviability of strain in which expression of CSL4 is repressed","page_type":"protein","species":{"key":"s_cerevisiae","name":"Saccharomyces 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cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; targeted to vacuole via AP-3 pathway; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)"},{"page_type":"protein","description":"Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; required for genome stability; plays a role in copper homeostasis","name":{"class":"protein","other_names":null,"id":"SGD:YOL123W","taxonomy":"s_cerevisiae","label":"HRP1","highlight":{"description_all":["cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3'"]}},"wbid":"SGD:YOL123W","taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces 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cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"GPD2"},{"name":{"taxonomy":"s_cerevisiae","id":"SGD:YER072W","label":"VTC1","highlight":{"description_all":["regulator of substrate invagination from the vacuolar membrane; also binds mRNA; targeted to vacuole via AP-3"]},"other_names":null,"class":"protein"},"wbid":"SGD:YER072W","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"label":"VTC1","description":"Regulatory subunit of vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; also binds mRNA; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress","page_type":"protein"},{"page_type":"protein","description":"Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3' end processing of 18S rRNA in context of 80S ribosomes that have not yet engaged in translation; involved in replication and maintenance of killer double stranded RNA virus","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"label":"RPL3","wbid":"SGD:YOR063W","name":{"other_names":null,"class":"protein","highlight":{"description_all":["ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3'"]},"id":"SGD:YOR063W","taxonomy":"s_cerevisiae","label":"RPL3"}},{"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"SEN34","name":{"highlight":{"description_all":["complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen34p contains the active site for tRNA 3'"]},"label":"SEN34","taxonomy":"s_cerevisiae","id":"SGD:YAR008W","class":"protein","other_names":null},"wbid":"SGD:YAR008W","description":"Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease","page_type":"protein"},{"page_type":"protein","description":"Pumilio-homology domain protein; binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; co-sediments with the 60S ribosomal subunit and is required for its biogenesis","taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"label":"PUF6","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"wbid":"SGD:YDR496C","name":{"id":"SGD:YDR496C","taxonomy":"s_cerevisiae","label":"PUF6","highlight":{"description_all":["Pumilio-homology domain protein; binds the 3' UTR of ASH1 mRNA and represses its translation, resulting"]},"class":"protein","other_names":null}},{"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"RIM11","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"wbid":"SGD:YMR139W","name":{"class":"protein","other_names":null,"taxonomy":"s_cerevisiae","id":"SGD:YMR139W","label":"RIM11","highlight":{"description_all":["complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-"]}},"description":"Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication","page_type":"protein"},{"wbid":"SGD:YOL047C","name":{"other_names":null,"class":"protein","highlight":{"description_all":["outside of the prospore membrane; shares similarity with Lds1p and Rrt8p, and a strain mutant for all 3"]},"id":"SGD:YOL047C","taxonomy":"s_cerevisiae","label":"LDS2"},"label":"LDS2","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"description":"Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds1p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern","page_type":"protein"},{"description":"RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation","page_type":"protein","name":{"other_names":null,"class":"protein","taxonomy":"s_cerevisiae","id":"SGD:YJL140W","label":"RPB4","highlight":{"description_all":["phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'"]}},"wbid":"SGD:YJL140W","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"RPB4"},{"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"PHO91","wbid":"SGD:YNR013C","name":{"taxonomy":"s_cerevisiae","label":"PHO91","id":"SGD:YNR013C","highlight":{"description_all":["localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3"]},"other_names":null,"class":"protein"},"page_type":"protein","description":"Low-affinity vacuolar phosphate transporter; exports phosphate from vacuolar lumen to cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of PHO pathway; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth"},{"page_type":"protein","description":"Histone chaperone; regulates chromatin structure, transcription, mRNA 3'-end formation and genome stability; role in chromatin remodeling and nucleosome assembly; required for initiation of DNA replication, promoting origin licensing through MCM helicase loading; required for fidelity of promoter selection through maintenance of chromatin structure during transcription; required for H3K36 trimethylation but not dimethylation by Set2p","label":"SPT6","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"wbid":"SGD:YGR116W","name":{"class":"protein","other_names":null,"taxonomy":"s_cerevisiae","id":"SGD:YGR116W","label":"SPT6","highlight":{"description_all":["Histone chaperone; regulates chromatin structure, transcription, mRNA 3'-end formation and genome stability"]}}},{"name":{"other_names":null,"class":"protein","label":"MAG1","taxonomy":"s_cerevisiae","id":"SGD:YER142C","highlight":{"description_all":["3-methyl-adenine DNA glycosylase; initiates base excision repair (BER) by removing damaged bases to create"]}},"wbid":"SGD:YER142C","label":"MAG1","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"description":"3-methyl-adenine DNA glycosylase; initiates base excision repair (BER) by removing damaged bases to create abasic sites that are subsequently repaired; expansion of BER repair removes alkylated bases resulting from alkylating agent-induced DNA damage, compensating for the lack of DNA repair by oxidative dealkylation; protein abundance increases in response to DNA replication stress","page_type":"protein"},{"wbid":"SGD:YML117W","name":{"taxonomy":"s_cerevisiae","label":"NAB6","id":"SGD:YML117W","highlight":{"description_all":["mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and stabilizes these mRNAs, acting"]},"other_names":null,"class":"protein"},"label":"NAB6","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"page_type":"protein","description":"mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and stabilizes these mRNAs, acting in parallel to cell wall integrity signaling to maintain expression of cell wall genes during stress; acts antagonistically to Nab6p; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP"},{"page_type":"protein","description":"Iron-sulfur protein required for synthesis of wybutosine modified tRNA; wybutosine is a modified guanosine found at 3'-position adjacent to anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"TYW1","name":{"other_names":null,"class":"protein","taxonomy":"s_cerevisiae","label":"TYW1","id":"SGD:YPL207W","highlight":{"description_all":["protein required for synthesis of wybutosine modified tRNA; wybutosine is a modified guanosine found at 3'"]}},"wbid":"SGD:YPL207W"},{"description":"Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation","page_type":"protein","name":{"highlight":{"description_all":["alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-"]},"taxonomy":"s_cerevisiae","id":"SGD:YHR007C","label":"ERG11","class":"protein","other_names":null},"wbid":"SGD:YHR007C","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"label":"ERG11","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"}},{"description":"GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains","page_type":"protein","label":"LRG1","taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"wbid":"SGD:YDL240W","name":{"highlight":{"description_all":["biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3"]},"taxonomy":"s_cerevisiae","label":"LRG1","id":"SGD:YDL240W","class":"protein","other_names":null}},{"page_type":"protein","description":"RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation","label":"RPB7","taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"name":{"other_names":null,"class":"protein","id":"SGD:YDR404C","taxonomy":"s_cerevisiae","label":"RPB7","highlight":{"description_all":["phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'"]}},"wbid":"SGD:YDR404C"},{"name":{"class":"protein","other_names":null,"taxonomy":"s_cerevisiae","id":"SGD:YMR054W","label":"STV1","highlight":{"description_all":["required for efficient localization and function of Stv1-containing V-ATPases; targeted to vacuole via AP-3"]}},"wbid":"SGD:YMR054W","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"label":"STV1","page_type":"protein","description":"Subunit a of vacuolar-ATPase V0 domain; encodes one of two isoforms, located in both Golgi and endosomal V-ATPase complexes while VPH1 encodes second isoform and is located in vacuolar V-ATPase complexes; interaction with PI(4)P is required for efficient localization and function of Stv1-containing V-ATPases; targeted to vacuole via AP-3 pathway"},{"wbid":"SGD:YLR136C","name":{"highlight":{"description_all":["mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated"]},"taxonomy":"s_cerevisiae","id":"SGD:YLR136C","label":"TIS11","other_names":null,"class":"protein"},"label":"TIS11","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"description":"mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; represses mitochondrial function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication","page_type":"protein"},{"wbid":"SGD:YNL010W","name":{"class":"protein","other_names":null,"highlight":{"description_all":["phosphatase; polyol phosphatase that hydrolyzes sorbitol-6-phosphate, ribitol-5-phosphate, and (D)-glycerol-3-"]},"taxonomy":"s_cerevisiae","label":"PYP1","id":"SGD:YNL010W"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"label":"PYP1","description":"Sugar alcohol phosphatase; polyol phosphatase that hydrolyzes sorbitol-6-phosphate, ribitol-5-phosphate, and (D)-glycerol-3-phosphate, maintaining phosphoglucose isomerase (PGI) activity in the presence of PGI-inhibitory sugar alcohols; expression correlated with growth rate; GFP-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant displays increased glycogen accumulation; member of the haloacid dehalogenase (HAD) superfamily","page_type":"protein"},{"wbid":"SGD:YKL113C","name":{"highlight":{"description_all":["5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation,"]},"taxonomy":"s_cerevisiae","id":"SGD:YKL113C","label":"RAD27","class":"protein","other_names":null},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"label":"RAD27","page_type":"protein","description":"5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; cleaves off RNA flap in a RNA:DNA hybrid intermediate during processing of DNA lagging strand; relocalizes to the cytosol in response to hypoxia; member of the S. pombe RAD2/FEN1 family"},{"description":"Double-stranded DNA-dependent helicase of the DExH/D-box family; branch point-binding helicase that preferentially unwinds the nascent lagging strand with a 3' to 5' polarity at a replication fork; contains double-stranded DNA translocase activity; responsible for DNA branch migration; required for maintenance of the mitochondrial (mt) genome; localizes to the mitochondrial matrix; monomeric","page_type":"protein","wbid":"SGD:YDR332W","name":{"highlight":{"description_all":["family; branch point-binding helicase that preferentially unwinds the nascent lagging strand with a 3'"]},"taxonomy":"s_cerevisiae","id":"SGD:YDR332W","label":"IRC3","other_names":null,"class":"protein"},"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"IRC3"},{"wbid":"SGD:YOR076C","name":{"class":"protein","other_names":null,"highlight":{"description_all":["protein that couples the Ski complex and exosome; putative pseudo-translational GTPase involved in 3'"]},"taxonomy":"s_cerevisiae","label":"SKI7","id":"SGD:YOR076C"},"taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"label":"SKI7","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"description":"GTP-binding protein that couples the Ski complex and exosome; putative pseudo-translational GTPase involved in 3'-to-5' mRNA decay pathway; interacts with both the cytoplasmic exosome and the Ski complex; eRF3-like domain targets nonstop mRNA for degradation; null mutants have a superkiller phenotype; SKI7 has a paralog, HBS1, that arose from the whole genome duplication","page_type":"protein"},{"page_type":"protein","description":"NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"GPD1","wbid":"SGD:YDL022W","name":{"other_names":null,"class":"protein","highlight":{"description_all":["NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth"]},"taxonomy":"s_cerevisiae","id":"SGD:YDL022W","label":"GPD1"}},{"page_type":"protein","description":"Vacuolar protein; involved in oxidative stress response and modulation of replicative lifespan; targeted to vacuole via AP-3 pathway; undergoes autophosphorylation, which is abolished by mutation of Asp781 in catalytic motif (D781N); P5 ATPase subfamily member with similarity to yeast Spf1p and homology to human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome","wbid":"SGD:YOR291W","name":{"class":"protein","other_names":null,"highlight":{"description_all":["involved in oxidative stress response and modulation of replicative lifespan; targeted to vacuole via AP-3"]},"taxonomy":"s_cerevisiae","label":"YPK9","id":"SGD:YOR291W"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"label":"YPK9"},{"taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"GRE2","name":{"taxonomy":"s_cerevisiae","label":"GRE2","id":"SGD:YOL151W","highlight":{"description_all":["3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic"]},"other_names":null,"class":"protein"},"wbid":"SGD:YOL151W","description":"3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase","page_type":"protein"},{"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"label":"YML003W","wbid":"SGD:YML003W","name":{"class":"protein","other_names":null,"highlight":{"description_all":["full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3'"]},"id":"SGD:YML003W","taxonomy":"s_cerevisiae","label":"YML003W"},"page_type":"protein","description":"Truncated 5' end of YML002W; in many strains, YML002W is continuous with YML003W, and is predicted to encode a single protein of 1090 aa with a full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3' end of YML003W at ChrXIII:264337, causing a frameshift and premature stop codon, truncating YML003W"},{"label":"NCR1","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"wbid":"SGD:YPL006W","name":{"other_names":null,"class":"protein","label":"NCR1","taxonomy":"s_cerevisiae","id":"SGD:YPL006W","highlight":{"description_all":["Neimann-Pick C disease caused by loss-of-function mutations in human NPC1; targeted to vacuole via AP-3"]}},"page_type":"protein","description":"Vacuolar membrane protein involved with Npc2p in sterol trafficking; transits through biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to accumulation of high amounts of lipids observed in patients with Neimann-Pick C disease caused by loss-of-function mutations in human NPC1; targeted to vacuole via AP-3 pathway"},{"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"label":"RPG1","wbid":"SGD:YBR079C","name":{"class":"protein","other_names":null,"highlight":{"description_all":["eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of"]},"label":"RPG1","taxonomy":"s_cerevisiae","id":"SGD:YBR079C"},"description":"eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; essential for loading mRNA onto ribosome at entry and exit channels of preinitiation complex; involved in translation reinitiation; eIF3 is also involved in programmed stop codon readthrough","page_type":"protein"},{"taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"label":"URA7","wbid":"SGD:YBL039C","name":{"other_names":null,"class":"protein","highlight":{"description_all":["novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; targeted to vacuole via AP-3"]},"taxonomy":"s_cerevisiae","id":"SGD:YBL039C","label":"URA7"},"page_type":"protein","description":"Major CTP synthase isozyme (see also URA8); catalyzes ATP-dependent transfer of amide nitrogen from glutamine to UTP, forming CTP, final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; targeted to vacuole via AP-3 pathway; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has paralog URA8 that arose from the whole genome duplication"},{"page_type":"protein","description":"Ubiquitin-like protein conjugated to phosphatidylethanolamine (PE); role in membrane fusion and phagophore expansion during autophagosome formation; deconjugation is also required for biogenesis; targets Atg1p to autophagosomes; binds to the Atg1p-Atg13p complex, triggers its vacuolar degradation; role in vacuolar membrane protein turnover during early stationary phase; component of autophagosomes and Cvt vesicles; targeted to vacuole via AP-3 pathway","name":{"other_names":null,"class":"protein","highlight":{"description_all":["during early stationary phase; component of autophagosomes and Cvt vesicles; targeted to vacuole via AP-3"]},"taxonomy":"s_cerevisiae","id":"SGD:YBL078C","label":"ATG8"},"wbid":"SGD:YBL078C","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"label":"ATG8"},{"description":"Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles in regulation of telomerase, telomere end protection, conventional telomere replication; regulates telomere replication through recruitment of specific sub-complexes, essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle","page_type":"protein","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"label":"CDC13","wbid":"SGD:YDL220C","name":{"highlight":{"description_all":["Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles in regulation of telomerase"]},"id":"SGD:YDL220C","taxonomy":"s_cerevisiae","label":"CDC13","class":"protein","other_names":null}},{"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"RAT1","name":{"highlight":{"description_all":["Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism, including rRNA and snoRNA"]},"id":"SGD:YOR048C","taxonomy":"s_cerevisiae","label":"RAT1","other_names":null,"class":"protein"},"wbid":"SGD:YOR048C","description":"Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism, including rRNA and snoRNA processing, as well as poly (A+) dependent and independent mRNA transcription termination; required for cotranscriptional pre-rRNA cleavage; displaces Cdk1p from elongating transcripts, especially as RNAPII reaches the poly(A) site, negatively regulates phosphorylation of the CTD of RNAPII, and inhibits RNAPII transcriptional elongation","page_type":"protein"},{"name":{"id":"SGD:YOL048C","taxonomy":"s_cerevisiae","label":"RRT8","highlight":{"description_all":["involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3"]},"other_names":null,"class":"protein"},"wbid":"SGD:YOL048C","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"RRT8","description":"Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress","page_type":"protein"},{"name":{"highlight":{"description_all":["domain is glycosylated; forms foci in vacuole membrane during starvation; targeted to vacuole via AP-3"]},"taxonomy":"s_cerevisiae","id":"SGD:YLR173W","label":"TAG1","other_names":null,"class":"protein"},"wbid":"SGD:YLR173W","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"TAG1","description":"Vacuolar membrane protein involved in termination of autophagy; regulates autophagy termination during persistent nitrogen starvation through Atg1p-mediated re-phosphorylation of Atg13p and PAS disassembly; type II membrane protein containing hydrophobic transmembrane region with N-terminal region oriented toward cytosol and C-terminus inside lumen; luminal domain is glycosylated; forms foci in vacuole membrane during starvation; targeted to vacuole via AP-3 pathway","page_type":"protein"},{"page_type":"protein","description":"Evolutionarily-conserved 5'-3' exonuclease; deNADding enzyme that modulates mitochondrial NAD-capped RNA; component of cytoplasmic P-bodies involved in mRNA decay; positively regulates transcription initiation and elongation; involved in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, telomere maintenance, and tRNA intron turnover; negative regulator of autophagy; activated by scavenger decapping enzyme Dcs1p; role in preventing L-A mycovirus pathogenesis","wbid":"SGD:YGL173C","name":{"class":"protein","other_names":null,"id":"SGD:YGL173C","taxonomy":"s_cerevisiae","label":"XRN1","highlight":{"description_all":["Evolutionarily-conserved 5'-3' exonuclease; deNADding enzyme that modulates mitochondrial NAD-capped"]}},"taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"label":"XRN1"},{"name":{"label":"CCC2","taxonomy":"s_cerevisiae","id":"SGD:YDR270W","highlight":{"description_all":["required for export of copper from cytosol into extracytosolic compartment; targeted to vacuole via AP-3"]},"other_names":null,"class":"protein"},"wbid":"SGD:YDR270W","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"label":"CCC2","description":"Cu(+2)-transporting P-type ATPase; required for export of copper from cytosol into extracytosolic compartment; targeted to vacuole via AP-3 pathway; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant","page_type":"protein"},{"wbid":"SGD:YGL178W","name":{"class":"protein","other_names":null,"highlight":{"description_all":["mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity"]},"id":"SGD:YGL178W","taxonomy":"s_cerevisiae","label":"MPT5"},"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"label":"MPT5","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"description":"mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity","page_type":"protein"},{"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"RRP6","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"wbid":"SGD:YOR001W","name":{"taxonomy":"s_cerevisiae","id":"SGD:YOR001W","label":"RRP6","highlight":{"description_all":["Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved"]},"other_names":null,"class":"protein"},"page_type":"protein","description":"Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based"},{"wbid":"SGD:YBR223C","name":{"id":"SGD:YBR223C","taxonomy":"s_cerevisiae","label":"TDP1","highlight":{"description_all":["Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of"]},"other_names":null,"class":"protein"},"label":"TDP1","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"description":"Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II, including DNA-protein cross-links; mutations in the human homolog, TDP1, result in the neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN)","page_type":"protein"},{"description":"Vacuole-specific Myo2p receptor; Myo2p-Vac17p-Vac8p transport complex subunit required for vacuolar inheritance; mediates anchoring of phosphatidylinositol 3-kinase complex I (PIK3C3-C1) to autophagosome; required with Atg13p for the vesicle closure step of the cytoplasm-to-vacuole (CVT) pathway, for homotypic vacuole-vacuole fusion and for nucleus-vacuole junction formation with Nvj1p; contains 11 armadillo (ARM) repeats; myristoylated, palmitoylated, and phosphorylated","page_type":"protein","name":{"other_names":null,"class":"protein","taxonomy":"s_cerevisiae","id":"SGD:YEL013W","label":"VAC8","highlight":{"description_all":["transport complex subunit required for vacuolar inheritance; mediates anchoring of phosphatidylinositol 3-"]}},"wbid":"SGD:YEL013W","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"VAC8"},{"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"SLX4","wbid":"SGD:YLR135W","name":{"other_names":null,"class":"protein","highlight":{"description_all":["in complex with Slx1p; involved in interstrand cross-link repair, Rad1p/Rad10p-dependent removal of 3'"]},"taxonomy":"s_cerevisiae","label":"SLX4","id":"SGD:YLR135W"},"page_type":"protein","description":"Endonuclease involved in processing DNA; acts during recombination, repair; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); cleaves branched structures in complex with Slx1p; involved in interstrand cross-link repair, Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress; FANCP-related factor"},{"description":"SR protein kinase (SRPK); involved in mRNA 3' splice site recognition with Prp8p and Cdc40p; phosphorylates one or more SR dipeptides on mRNA export factors Npl3p and Gbp2p to stimulate cytoplasmic release of mRNA and Mtr10p-mediated nuclear reimport; component of stress granules that regulates granule disassembly during recovery from stress; modulates cation uptake and homeostasis through membrane transporters; contains prion-like domains; similar to human SRPK1","page_type":"protein","label":"SKY1","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"wbid":"SGD:YMR216C","name":{"highlight":{"description_all":["SR protein kinase (SRPK); involved in mRNA 3' splice site recognition with Prp8p and Cdc40p; phosphorylates"]},"taxonomy":"s_cerevisiae","id":"SGD:YMR216C","label":"SKY1","class":"protein","other_names":null}},{"label":"SSA2","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"name":{"highlight":{"description_all":["enzymes; binds tRNA, has role in tRNA nuclear import during starvation; targeted to vacuole via AP-3"]},"label":"SSA2","taxonomy":"s_cerevisiae","id":"SGD:YLL024C","class":"protein","other_names":null},"wbid":"SGD:YLL024C","description":"HSP70 family ATP-binding protein; involved in protein folding, vacuolar import of proteins; required for ubiquitin-dependent degradation of short-lived proteins; associated with chaperonin-containing T-complex; 98% identical to paralog Ssa1p with distinct functional specificity in propagation of yeast [URE3] prions and vacuolar-mediated degradation of gluconeogenesis enzymes; binds tRNA, has role in tRNA nuclear import during starvation; targeted to vacuole via AP-3 pathway","page_type":"protein"},{"page_type":"protein","description":"Protein involved in polar growth, functionally redundant with Boi2p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication","wbid":"SGD:YBL085W","name":{"class":"protein","other_names":null,"taxonomy":"s_cerevisiae","label":"BOI1","id":"SGD:YBL085W","highlight":{"description_all":["sites of polarized growth; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3)"]}},"label":"BOI1","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"}},{"description":"Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention","page_type":"protein","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"label":"CHS3","name":{"class":"protein","other_names":null,"highlight":{"description_all":["intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3"]},"taxonomy":"s_cerevisiae","label":"CHS3","id":"SGD:YBR023C"},"wbid":"SGD:YBR023C"},{"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"CTK1","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"name":{"other_names":null,"class":"protein","taxonomy":"s_cerevisiae","id":"SGD:YKL139W","label":"CTK1","highlight":{"description_all":["kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3'"]}},"wbid":"SGD:YKL139W","description":"Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13","page_type":"protein"},{"description":"Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication","page_type":"protein","wbid":"SGD:YNL001W","name":{"highlight":{"description_all":["dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3'"]},"taxonomy":"s_cerevisiae","label":"DOM34","id":"SGD:YNL001W","other_names":null,"class":"protein"},"label":"DOM34","taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"}},{"page_type":"protein","description":"3'-5' DNA helicase of the conserved RecQ family; involved in Pso2p-mediated interstrand crosslink repair; acts with Rad4p in nucleotide-excision repair; binds telomeres, modulates telomerase activity with Pif1p and inhibits telomere addition to dsDNA breaks; role in telomerase-independent telomere maintenance; lacks ssDNA annealing and strand exchange activities; human RecQL4, a structural and functional homolog, is involved in Rothmund-Thomson, Baller-Gerold and RAPADILINO syndromes","name":{"id":"SGD:YDR291W","taxonomy":"s_cerevisiae","label":"HRQ1","highlight":{"description_all":["3'-5' DNA helicase of the conserved RecQ family; involved in Pso2p-mediated interstrand crosslink repair"]},"other_names":null,"class":"protein"},"wbid":"SGD:YDR291W","label":"HRQ1","taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"}},{"description":"Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; involved in synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; G353A missense mutation in human ortholog ALG3 implicated in carbohydrate deficient glycoprotein syndrome type IV, which is characterized by microcephaly, severe epilepsy, minimal psychomotor development, partial deficiency of sialic acids in serum glycoproteins; wild-type human ALG3 can complement yeast alg3 mutant","page_type":"protein","name":{"other_names":null,"class":"protein","highlight":{"description_all":["Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; involved in synthesis of dolichol-linked oligosaccharide"]},"taxonomy":"s_cerevisiae","id":"SGD:YBL082C","label":"ALG3"},"wbid":"SGD:YBL082C","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"label":"ALG3"},{"page_type":"protein","description":"ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; binds to 3'UTR of HAC1 mRNA and limits its nuclear export attenuating the UPR","label":"ISW1","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"wbid":"SGD:YBR245C","name":{"other_names":null,"class":"protein","taxonomy":"s_cerevisiae","id":"SGD:YBR245C","label":"ISW1","highlight":{"description_all":["H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; binds to 3'"]}}},{"taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"label":"NRD1","wbid":"SGD:YNL251C","name":{"highlight":{"description_all":["RNA-binding subunit of Nrd1 complex; complex interacts with exosome to mediate 3'-end formation of some"]},"taxonomy":"s_cerevisiae","label":"NRD1","id":"SGD:YNL251C","other_names":null,"class":"protein"},"page_type":"protein","description":"RNA-binding subunit of Nrd1 complex; complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with CTD of RNA pol II large subunit Rpo21p at phosphorylated Ser5 to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; role in regulation of mitochondrial abundance and cell size"},{"wbid":"SGD:YOR033C","name":{"taxonomy":"s_cerevisiae","id":"SGD:YOR033C","label":"EXO1","highlight":{"description_all":["5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2"]},"class":"protein","other_names":null},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"label":"EXO1","description":"5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication","page_type":"protein"},{"page_type":"protein","description":"eIF3j component of translation initiation factor 3 (eIF3); dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of eIF3; required for 20S pre-rRNA processing; required at post-transcriptional step for efficient retrotransposition; absence decreases Ty1 Gag:GFP protein levels; binds eIF3 subunits Rpg1p, Prt1p and 18S rRNA; eIF3 also involved in programmed stop codon read through; human homolog EIF3J can complement yeast hcr1 mutant","wbid":"SGD:YLR192C","name":{"taxonomy":"s_cerevisiae","id":"SGD:YLR192C","label":"HCR1","highlight":{"description_all":["eIF3j component of translation initiation factor 3 (eIF3); dual function protein involved in translation"]},"other_names":null,"class":"protein"},"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"HCR1"},{"taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"label":"HMO1","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"wbid":"SGD:YDR174W","name":{"other_names":null,"class":"protein","highlight":{"description_all":["selection of ribosomal protein genes via RNAPII promoters; role in genome maintenance; associates with a 5'-3'"]},"taxonomy":"s_cerevisiae","label":"HMO1","id":"SGD:YDR174W"},"description":"Chromatin-associated high mobility group (HMG) family member; role in compacting, bending, bridging and looping DNA; lysine-rich CTD is essential for chromatin assembly, forming condensates with dsDNA; functionally similar to linker histone H1; rDNA-binding component regulates transcription from RNAPI promoters; regulates start site selection of ribosomal protein genes via RNAPII promoters; role in genome maintenance; associates with a 5'-3' DNA helicase and Fpr1p","page_type":"protein"},{"description":"Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; also enters the nucleus and positively regulates transcription initiation; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation, most often in the 3' UTR; forms cytoplasmic foci upon DNA replication stress","page_type":"protein","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"LSM1","wbid":"SGD:YJL124C","name":{"other_names":null,"class":"protein","highlight":{"description_all":["SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation, most often in the 3'"]},"taxonomy":"s_cerevisiae","id":"SGD:YJL124C","label":"LSM1"}},{"page_type":"protein","description":"Poly(A) binding protein; interacts with the cleavage factor complex CF I, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; stimulates, but is not required for the deadenylation activity of the Pan2p-Pan3p poly(A)-ribonuclease complex; role in preventing L-A mycovirus pathogenesis","wbid":"SGD:YER165W","name":{"taxonomy":"s_cerevisiae","label":"PAB1","id":"SGD:YER165W","highlight":{"description_all":["interacts with the cleavage factor complex CF I, mediates interactions between the 5' cap structure and the 3'"]},"other_names":null,"class":"protein"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"label":"PAB1"},{"name":{"other_names":null,"class":"protein","highlight":{"description_all":["pyridoxal-5'-phosphate synthase; involved in pyridoxine (vitamin B6) biosynthesis from glyceraldehyde-3-"]},"taxonomy":"s_cerevisiae","label":"SNZ1","id":"SGD:YMR096W"},"wbid":"SGD:YMR096W","taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"SNZ1","page_type":"protein","description":"Subunit of a two-component pyridoxal-5'-phosphate synthase; involved in pyridoxine (vitamin B6) biosynthesis from glyceraldehyde-3-phosphate, ribose-5-phosphate and ammonia liberated from glutamine by glutaminase; forms a complex with Sno1p that functions as an active glutaminase; member of a stationary phase-induced gene family where transcriptional induction occurs during the postdiauxic phase; co-regulated with SNO1; paralog of SNZ2 and SNZ3"},{"page_type":"protein","description":"Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"label":"VID30","wbid":"SGD:YGL227W","name":{"other_names":null,"class":"protein","id":"SGD:YGL227W","taxonomy":"s_cerevisiae","label":"VID30","highlight":{"description_all":["strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3"]}}},{"label":"IMA3","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"wbid":"SGD:YIL172C","name":{"highlight":{"description_all":["isomaltose; lower activitiy and thermostability in vitro than Ima2p despite sequence difference of only 3"]},"label":"IMA3","taxonomy":"s_cerevisiae","id":"SGD:YIL172C","other_names":null,"class":"protein"},"description":"Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose; lower activitiy and thermostability in vitro than Ima2p despite sequence difference of only 3 amino acids; cleaves alpha-1,3 linkage of nigerose and turanose, but not alpha-1,5 of leucrose; identical to IMA4","page_type":"protein"},{"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"label":"SEC13","wbid":"SGD:YLR208W","name":{"other_names":null,"class":"protein","label":"SEC13","taxonomy":"s_cerevisiae","id":"SGD:YLR208W","highlight":{"description_all":["Structural component of 3 complexes; subunit of the Nup84p nuclear pore subcomplex that contributes to"]}},"description":"Structural component of 3 complexes; subunit of the Nup84p nuclear pore subcomplex that contributes to nucleocytoplasmic transport and NPC biogenesis; subunit of the COPII vesicle coat required for ER-to-Golgi transport; subunit of SEACAT, a subcomplex of the coatomer-related, vacuolar-associated SEA complex, that inhibits the TORC1 inhibitory role of SEACIT (Iml1p-Npr2p-Npr3p), a GAP for Gtr1p, thereby resulting in activation of TORC1 signaling; human SEC13 homolog","page_type":"protein"},{"description":"Putative protein of unknown function; expression induced by heat and by calcium shortage; in many strains, YML002W is continuous with YML003W, and is predicted to encode a single protein of 1090 aa with a full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3' end of YML003W at ChrXIII:264337, causing a frameshift and premature stop codon, truncating YML003W","page_type":"protein","wbid":"SGD:YML002W","name":{"highlight":{"description_all":["full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3'"]},"taxonomy":"s_cerevisiae","id":"SGD:YML002W","label":"VRL1","class":"protein","other_names":null},"taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"label":"VRL1"},{"page_type":"protein","description":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from wine yeast Wickerhamomyces anomalus or close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-1 has paralog ASP3-3 that arose from a segmental duplication","name":{"class":"protein","other_names":null,"taxonomy":"s_cerevisiae","id":"SGD:YLR155C","label":"ASP3-1","highlight":{"description_all":["preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-1 has paralog ASP3-3"]}},"wbid":"SGD:YLR155C","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"ASP3-1"},{"description":"RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability","page_type":"protein","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"label":"NAB3","wbid":"SGD:YPL190C","name":{"id":"SGD:YPL190C","taxonomy":"s_cerevisiae","label":"NAB3","highlight":{"description_all":["RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'"]},"class":"protein","other_names":null}},{"page_type":"protein","description":"Subunit of heterodimeric guanine nucleotide exchange factor (GEF); subunit of Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; role in localizing Ypt7p to vacuolar membrane; required for autophagy, CVT pathway, and mitophagy; targeted to vacuole via AP-3 pathway","taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"label":"MON1","name":{"highlight":{"description_all":["to vacuolar membrane; required for autophagy, CVT pathway, and mitophagy; targeted to vacuole via AP-3"]},"id":"SGD:YGL124C","taxonomy":"s_cerevisiae","label":"MON1","class":"protein","other_names":null},"wbid":"SGD:YGL124C"},{"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"PHO92","name":{"id":"SGD:YDR374C","taxonomy":"s_cerevisiae","label":"PHO92","highlight":{"description_all":["transcript abundance, and the timing of meiotic recombination; regulates PHO4 mRNA stability, binding to the 3'"]},"other_names":null,"class":"protein"},"wbid":"SGD:YDR374C","page_type":"protein","description":"N6-Methyladenosine (m6A) reader; co-transcriptionally recruited to specific methylated mRNAs during meiotic prophase, contributing to the down-regulation of transcript abundance, and the timing of meiotic recombination; regulates PHO4 mRNA stability, binding to the 3'UTR in a phosphate-dependent manner; posttranscriptional regulator of phosphate and glucose metabolism; contains a highly conserved YTH domain that exhibits RNA-binding activity; human homolog YTHDF2 can complement yeast null mutant"},{"name":{"other_names":null,"class":"protein","taxonomy":"s_cerevisiae","id":"SGD:YGL023C","label":"PIB2","highlight":{"description_all":["Phosphatidylinositol 3-phosphate binding protein; formation of a distinct complex with TORC1, induced"]}},"wbid":"SGD:YGL023C","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"PIB2","description":"Phosphatidylinositol 3-phosphate binding protein; formation of a distinct complex with TORC1, induced by glutamine in dose-dependent manner, results in TORC1 activation, suggesting dual roles as both a glutamine sensor and a direct TORC1 activator; involved in leucine- and glutamine-responsive TORC1 activation, independent of the Gtr/Ego pathway; related to human PLEKHF1, a lysosomal membrane permeabilization regulator; contains a PtdIns3P binding FYVE domain; similar to Fab1p and Vps27p","page_type":"protein"},{"wbid":"SGD:YEL060C","name":{"other_names":null,"class":"protein","id":"SGD:YEL060C","taxonomy":"s_cerevisiae","label":"PRB1","highlight":{"description_all":["stress; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via AP-3"]}},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"PRB1","page_type":"protein","description":"Vacuolar proteinase B yscB with H3 N-terminal endopeptidase activity; serine protease of subtilisin family; involved in protein degradation in vacuole; required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via AP-3 pathway; PRB1 has a paralog, YSP3, that arose from the whole genome duplication"},{"name":{"other_names":null,"class":"protein","label":"TOR1","taxonomy":"s_cerevisiae","id":"SGD:YJR066W","highlight":{"description_all":[", transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; indole-3-"]}},"wbid":"SGD:YJR066W","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"TOR1","page_type":"protein","description":"PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; indole-3-acetic acid, an ATP-competitive TORC1 inhibitor, accumulates upon entry into stationary phase; malonyl-CoA is a direct ATP-competitive inhibitor of TORC1; TOR1 has a paralog, TOR2, that arose from the whole genome duplication"},{"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"label":"ASP3-3","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"wbid":"SGD:YLR158C","name":{"highlight":{"description_all":["; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-3"]},"id":"SGD:YLR158C","taxonomy":"s_cerevisiae","label":"ASP3-3","class":"protein","other_names":null},"description":"Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-3 has a paralog, ASP3-1, that arose from a segmental duplication","page_type":"protein"},{"page_type":"protein","description":"Phosphoinositide binding protein; required for vesicle formation in cytoplasm-to-vacuole targeting (CVT) pathway, autophagy, micronucleophagy and mitophagy; binds to several phosphoinositides including PtdIns(3,5)P2, PI3P and PI4P; involved in PI3P-dependent recruitment and organization of both Atg12-Atg5-Atg16 complex and Atg8p at pre-autophagosomal structure; necessary for oxidant-induced cell death; targeted to vacuole via AP-3 pathway; WD-40 repeat containing PROPPIN family member","wbid":"SGD:YPL100W","name":{"taxonomy":"s_cerevisiae","id":"SGD:YPL100W","label":"ATG21","highlight":{"description_all":["pre-autophagosomal structure; necessary for oxidant-induced cell death; targeted to vacuole via AP-3"]},"other_names":null,"class":"protein"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"ATG21","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"}},{"description":"Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication","page_type":"protein","wbid":"SGD:YMR186W","name":{"id":"SGD:YMR186W","taxonomy":"s_cerevisiae","label":"HSC82","highlight":{"description_all":["they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3"]},"other_names":null,"class":"protein"},"label":"HSC82","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"}},{"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"MRN1","name":{"other_names":null,"class":"protein","highlight":{"description_all":["mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and destabilizes these mRNAs during"]},"taxonomy":"s_cerevisiae","id":"SGD:YPL184C","label":"MRN1"},"wbid":"SGD:YPL184C","page_type":"protein","description":"mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and destabilizes these mRNAs during stress, acting antagonistically to Nab6p; links cell wall homeostasis to mitochondrial structure and function; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation"},{"wbid":"SGD:YGL044C","name":{"other_names":null,"class":"protein","highlight":{"description_all":["complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3'"]},"taxonomy":"s_cerevisiae","label":"RNA15","id":"SGD:YGL044C"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"RNA15","page_type":"protein","description":"Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability"},{"wbid":"SGD:YML121W","name":{"highlight":{"description_all":["oxidative stress response; activated by Iml1p (GAP) subunit of SEACIT complex; targeted to vacuole via AP-3"]},"taxonomy":"s_cerevisiae","id":"SGD:YML121W","label":"GTR1","class":"protein","other_names":null},"label":"GTR1","taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"description":"Subunit of TORC1-stimulating GTPase and EGO/GSE complex; subunit of Gtr1-Gtr2 GTPase that activates TORC1 in response to amino acid stimulation; subunit of EGO/GSE vacuolar membrane complex that regulates exit from rapamycin-induced growth arrest and sorting of Gap1p; involved in phosphate transport, telomeric chromatin silencing and oxidative stress response; activated by Iml1p (GAP) subunit of SEACIT complex; targeted to vacuole via AP-3 pathway; similar to human RagA and RagB","page_type":"protein"},{"page_type":"protein","description":"Nucleolar protein involved in the asymmetric localization of ASH1 mRNA; binds cooperatively with She2p to the E3 zip-code element in the 3'-UTR of the mRNA; constituent of 66S pre-ribosomal particles involved in pre-rRNA processing and nuclear export of the 60S subunit; may facilitate Rpl43p loading; required post-transcriptionally for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; relocalizes from nucleus to cytoplasm upon DNA replication stress","name":{"class":"protein","other_names":null,"highlight":{"description_all":["asymmetric localization of ASH1 mRNA; binds cooperatively with She2p to the E3 zip-code element in the 3'"]},"label":"LOC1","taxonomy":"s_cerevisiae","id":"SGD:YFR001W"},"wbid":"SGD:YFR001W","label":"LOC1","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"}},{"wbid":"SGD:YNL242W","name":{"taxonomy":"s_cerevisiae","label":"ATG2","id":"SGD:YNL242W","highlight":{"description_all":["autophagosome formation; involved in Atg9p cycling between the PAS and mitochondria; binds the phospholipid PI(3)"]},"class":"protein","other_names":null},"label":"ATG2","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"page_type":"protein","description":"Putative lipid transport protein; peripheral membrane protein required for vesicle formation during autophagy, pexophagy and the CVT pathway; directed to autophagic membranes by Atg18p where it acts as a PAS-ER membrane tether during autophagosome formation; involved in Atg9p cycling between the PAS and mitochondria; binds the phospholipid PI(3)P via an APT1 domain; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress"},{"page_type":"protein","description":"AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift","name":{"taxonomy":"s_cerevisiae","label":"ABP140","id":"SGD:YOR239W","highlight":{"description_all":["AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-"]},"other_names":null,"class":"protein"},"wbid":"SGD:YOR239W","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"taxonomy":{"genus":"Saccharomyces","id":"s_cerevisiae","species":"cerevisiae"},"label":"ABP140"},{"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"label":"BOI2","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"name":{"taxonomy":"s_cerevisiae","id":"SGD:YER114C","label":"BOI2","highlight":{"description_all":["until the end of cytokinesis; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3)"]},"class":"protein","other_names":null},"wbid":"SGD:YER114C","page_type":"protein","description":"Protein involved in polar growth; functionally redundant with Boi1p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth and for inhibition of membrane abscission until the end of cytokinesis; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI2 has a paralog, BOI1, that arose from the whole genome duplication"},{"description":"Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase; detects polyadenylation signal in nascent pre-mRNA and triggers 3' end formation of mRNA via cleavage and polyadenylation; binds pre-mRNA via zinc knuckle and RING finger; E3 ubiquitin ligase involved in polyubiquitination of endonuclease Ysh1p; contains a ubiquitin-like (UBL) domain, a RNA-binding zinc knuckle motif and a RING finger domain; relocalizes to cytosol in response to hypoxia; homolog of human RBBP6","page_type":"protein","wbid":"SGD:YKL059C","name":{"taxonomy":"s_cerevisiae","label":"MPE1","id":"SGD:YKL059C","highlight":{"description_all":["polyadenylation factor and E3 Ub-ligase; detects polyadenylation signal in nascent pre-mRNA and triggers 3'"]},"other_names":null,"class":"protein"},"label":"MPE1","taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"}},{"name":{"highlight":{"description_all":["3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity"]},"id":"SGD:YIR002C","taxonomy":"s_cerevisiae","label":"MPH1","other_names":null,"class":"protein"},"wbid":"SGD:YIR002C","label":"MPH1","taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"page_type":"protein","description":"3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; homolog of human FANCM Fanconi anemia protein that is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; nonsense or missense mutations in FANCM can make people more likely to get cancer"},{"name":{"other_names":null,"class":"protein","highlight":{"description_all":["Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy"]},"taxonomy":"s_cerevisiae","id":"SGD:YPL120W","label":"VPS30"},"wbid":"SGD:YPL120W","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"label":"VPS30","description":"Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant","page_type":"protein"},{"description":"Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; accounts for most acyl-CoA synthetase activity; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms ER foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4","page_type":"protein","wbid":"SGD:YOR317W","name":{"class":"protein","other_names":null,"taxonomy":"s_cerevisiae","id":"SGD:YOR317W","label":"FAA1","highlight":{"description_all":["ER foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3,"]}},"label":"FAA1","taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"}},{"wbid":"SGD:YOR086C","name":{"highlight":{"description_all":["Sac1p phosphatase to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; contains 3"]},"taxonomy":"s_cerevisiae","label":"TCB1","id":"SGD:YOR086C","other_names":null,"class":"protein"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"TCB1","description":"Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane (PM); regulates PI4P levels by controlling access of the Sac1p phosphatase to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; contains 3 calcium and lipid binding domains; localizes to the cortical ER and to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact","page_type":"protein"},{"description":"Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; role in stationary phase survival; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4","page_type":"protein","species":{"key":"s_cerevisiae","name":"Saccharomyces cerevisiae"},"taxonomy":{"species":"cerevisiae","id":"s_cerevisiae","genus":"Saccharomyces"},"label":"FAA4","wbid":"SGD:YMR246W","name":{"highlight":{"description_all":["cytoplasmic foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3,"]},"taxonomy":"s_cerevisiae","id":"SGD:YMR246W","label":"FAA4","class":"protein","other_names":null}},{"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"label":"RNA14","wbid":"SGD:YMR061W","name":{"highlight":{"description_all":["complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3'"]},"taxonomy":"s_cerevisiae","id":"SGD:YMR061W","label":"RNA14","class":"protein","other_names":null},"description":"Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability; relocalizes to the cytosol in response to hypoxia","page_type":"protein"},{"wbid":"SGD:YJL050W","name":{"other_names":null,"class":"protein","taxonomy":"s_cerevisiae","label":"MTR4","id":"SGD:YJL050W","highlight":{"description_all":["RNA duplex-sensing translocase; ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear"]}},"taxonomy":{"genus":"Saccharomyces","species":"cerevisiae","id":"s_cerevisiae"},"label":"MTR4","species":{"name":"Saccharomyces cerevisiae","key":"s_cerevisiae"},"page_type":"protein","description":"RNA duplex-sensing translocase; ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing"},{"description":"Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane (PM); regulates PI4P levels by controlling access of Sac1p to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; contains 3 calcium and lipid binding domains; localizes to the cortical ER, the cell periphery and is enriched in bud membranes; mRNA is targeted to the bud tip","page_type":"protein","wbid":"SGD:YNL087W","name":{"class":"protein","other_names":null,"highlight":{"description_all":["controlling access of Sac1p to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; contains 3"]},"taxonomy":"s_cerevisiae","id":"SGD:YNL087W","label":"TCB2"},"taxonomy":{"id":"s_cerevisiae","species":"cerevisiae","genus":"Saccharomyces"},"species":{"name":"Saccharomyces 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