Flybase gene name is <em>Nca</em>-PA Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts <em>2</em>-oxoisovalerate into <em>2</em>-dehydropantoate <em>2</em>-dehydropantoate <em>2</em>-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli Mitochondrial translation initiation factor <em>2</em> Putative <em>2</em>-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of <em>2</em>-methylcitrate to <em>2</em>-methylisocitrate Flybase gene name is Alg-<em>2</em>-PC Flybase gene name is Hmg-<em>2</em>-PA Flybase gene name is msl-<em>2</em>-PA Flybase gene name is NT5E-<em>2</em>-PA Alpha <em>2</em> subunit of the 20S proteasome Flybase gene name is spd-<em>2</em>-PA Flybase gene name is Tret1-<em>2</em>-PA Flybase gene name is Vha14-<em>2</em>-PA Flybase gene name is Vha68-<em>2</em>-PF Flybase gene name is Zip42C.<em>2</em>-PB Flybase gene name is Ance-<em>2</em>-PA Flybase gene name is Dcr-<em>2</em>-PA Flybase gene name is Der-<em>2</em>-PA Flybase gene name is Fmo-<em>2</em>-PA Flybase gene name is galla-<em>2</em>-PA Flybase gene name is kl-<em>2</em>-PD Flybase gene name is Lsd-<em>2</em>-PA Flybase gene name is Mi-<em>2</em>-PB Flybase gene name is P5cr-<em>2</em>-PA Flybase gene name is pHCl-<em>2</em>-PB Flybase gene name is RpL37-<em>2</em>-PA Flybase gene name is Vha16-<em>2</em>-PA Flybase gene name is Vha36-<em>2</em>-PA Flybase gene name is VhaAC39-<em>2</em>-PA Flybase gene name is Ada1-<em>2</em>-PA Flybase gene name is Atf-<em>2</em>-PA Flybase gene name is Drl-<em>2</em>-PC Flybase gene name is I-<em>2</em>-PB Flybase gene name is Menl-<em>2</em>-PE Flybase gene name is Nup93-<em>2</em>-PA Flybase gene name is Pgam5-<em>2</em>-PA Flybase gene name is primo-<em>2</em>-PC Flybase gene name is TfAP-<em>2</em>-PD Flybase gene name is Trf4-<em>2</em>-PB Flybase gene name is Vha100-<em>2</em>-PA Flybase gene name is ari-<em>2</em>-PA Flybase gene name is cv-<em>2</em>-PA Flybase gene name is IA-<em>2</em>-PC Flybase gene name is Indy-<em>2</em>-PB Flybase gene name is nerfin-<em>2</em>-PB Flybase gene name is Ntf-<em>2</em>-PE Flybase gene name is p24-<em>2</em>-PB Flybase gene name is qkr58E-<em>2</em>-PB Flybase gene name is Reg-<em>2</em>-PA Flybase gene name is Smyd4-<em>2</em>-PA Flybase gene name is tbrd-<em>2</em>-PA Flybase gene name is VhaPPA1-<em>2</em>-PB Flybase gene name is Hsc70-<em>2</em>-PA Flybase gene name is pen-<em>2</em>-PB Flybase gene name is RluA-<em>2</em>-PD Flybase gene name is sens-<em>2</em>-PB Flybase gene name is SmydA-<em>2</em>-PA Small subunit of the clathrin-associated adaptor complex AP-<em>2</em>; AP-<em>2</em> is involved in protein sorting at membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-<em>2</em>) function; identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-<em>2</em> identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-<em>2</em> Flybase gene name is l(<em>2</em>)03659-PC Flybase gene name is l(<em>2</em>)05287-PB Flybase gene name is l(<em>2</em>)05714-PB Flybase gene name is l(<em>2</em>)10685-PA Flybase gene name is l(<em>2</em>)34Fc-PB Flybase gene name is l(<em>2</em>)34Fd-PA Flybase gene name is l(<em>2</em>)41Ab-PA Flybase gene name is l(<em>2</em>)efl-PC Flybase gene name is l(<em>2</em>)k05819-PA Flybase gene name is l(<em>2</em>)k14505-PB Flybase gene name is c(<em>2</em>)M-PA Flybase gene name is l(<em>2</em>)gl-PJ Flybase gene name is l(<em>2</em>)k05911-PC Flybase gene name is l(<em>2</em>)k09022-PA Flybase gene name is l(<em>2</em>)k10201-PA Flybase gene name is l(<em>2</em>)SH0834-PA Flybase gene name is ms(<em>2</em>)34Fe-PA Flybase gene name is e(y)<em>2</em>-PA Flybase gene name is l(<em>2</em>)dtl-PA Flybase gene name is l(<em>2</em>)gd1-PB Flybase gene name is l(<em>2</em>)37Cd-PA Flybase gene name is l(<em>2</em>)k01209-PD Flybase gene name is TfIIA-S-<em>2</em>-PA Flybase gene name is fl(<em>2</em>)d-PA Flybase gene name is Fs(<em>2</em>)Ket-PE Flybase gene name is fs(<em>2</em>)ltoPP43-PA Flybase gene name is l(<em>2</em>)09851-PB Flybase gene name is l(<em>2</em>)37Bb-PA Flybase gene name is l(<em>2</em>)37Cb-PA Flybase gene name is l(<em>2</em>)k09848-PB Flybase gene name is l(<em>2</em>)k09913-PE Flybase gene name is ms(<em>2</em>)35Ci-PC Flybase gene name is ref(<em>2</em>)P-PB Flybase gene name is Su(z)<em>2</em>-PC Cargo-binding mu subunit of AP-<em>2</em>; AP-<em>2</em> is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-<em>2</em> function and localization, and binds cell wall stress receptor Mid2p; AP-<em>2</em> is required for cell polarity responses nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-<em>2</em> Flybase gene name is Su(var)<em>2</em>-10-PI Mitochondrial inner membrane transporter; <em>2</em>-oxodicarboxylate transporter, exports <em>2</em>-oxoadipate and <em>2</em>- Flybase gene name is Su(var)<em>2</em>-HP2-PA Mitochondrial inner membrane transporter; <em>2</em>-oxodicarboxylate transporter, exports <em>2</em>-oxoadipate and <em>2</em>- Mitochondrial inner membrane Mg(<em>2</em>+) channel; required for maintenance of intramitochondrial Mg(<em>2</em>+) concentrations tRNA <em>2</em>'-phosphotransferase; catalyzes the final step in tRNA splicing, transferring the <em>2</em>'-PO(4) from the splice junction to NAD(+), forming ADP-ribose 1''-<em>2</em>''cyclic phosphate and nicotinamide; ADP-ribosyltransferase <em>2</em>-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of <em>2</em>-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose tRNA-specific <em>2</em>-thiouridylase; responsible for <em>2</em>-thiolation of the wobble base of mitochondrial tRNAs Protein involved in <em>2</em>'-O-methylation of C32 of substrate tRNAs; interacts with <em>2</em>'-O-ribose methyltransferase complemented by human THADA, mutations in which have been implicated in epithelial thyroid adenomas, type <em>2</em> Protein of unknown function; dgr1 null mutant is resistant to <em>2</em>-deoxy-D-glucose D-<em>2</em>-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-<em>2</em>-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-<em>2</em> interacting protein BMRP Vacuolar cation channel; mediates release of Ca(<em>2</em>+) from the vacuole in response to hyperosmotic shock Inositol 1,3,4,5,6-pentakisphosphate <em>2</em>-kinase; nuclear protein required for synthesis of 1,2,3,4,5,6- hexakisphosphate (phytate), which is integral to cell function; has <em>2</em> motifs conserved in other fungi <em>2</em>'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-<em>2</em>); involved in vesicle mediated Elongation factor <em>2</em> (eEF2, EF-<em>2</em>), also encoded by EFT2; catalyzes ribosomal translocation during protein Eukaryotic translation elongation factor <em>2</em> (eEF2, EF-<em>2</em>); also encoded by EFT1; catalyzes ribosomal translocation Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(<em>2</em>)Am6(<em>2</em>) Dioxygenase that catalyzes alpha-oxygenation of <em>2</em>-hydroxy fatty acids; involved in metabolism of phytosphingosine <em>2</em>'-O-ribose methyltransferase; methylates the <em>2</em>'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in <em>2</em>' copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-<em>2</em>, in the genomic sequence reference strain S288C; CUP1-<em>2</em> has a paralog, CUP1-1, that arose from a segmental Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to <em>2</em>-phosphoglycerate copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-<em>2</em>, in the genomic sequence reference strain S288C; CUP1-1 has a paralog, CUP1-<em>2</em>, that arose from a segmental Pentafunctional arom protein; catalyzes steps <em>2</em> through 6 in the biosynthesis of chorismate, which is Plasma membrane Mg(<em>2</em>+) transporter; expression and turnover are regulated by Mg(<em>2</em>+) concentration; overexpression Enolase, a phosphopyruvate hydratase; catalyzes the conversion of <em>2</em>-phosphoglycerate to phosphoenolpyruvate Probable Mg(<em>2</em>+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to <em>2</em>, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-<em>2</em>-thiouridine; may act as part of a complex with Trm112p; deletion mutation Initiator methionine <em>2</em>'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position Protein with <em>2</em>-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/<em>2</em>- dependent manner by Ypk1/<em>2</em>/3p; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication <em>2</em>-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers <em>2</em>-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/<em>2</em>- dependent manner by Ypk1/<em>2</em>/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication 6-phosphofructo-<em>2</em>-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible <em>2</em>'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity Enolase, a phosphopyruvate hydratase; catalyzes the conversion of <em>2</em>-phosphoglycerate to phosphoenolpyruvate Similar to 6-phosphofructo-<em>2</em>-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor formation; inhibits Scd5p through phosphorylation; phosphorylates Pan1p-interacting proteins, Ent1/<em>2</em> and Yap1801/<em>2</em>; negatively regulated through autophosphorylation; functional overlap with ARK1 Cytochrome c isoform <em>2</em>, expressed under hypoxic conditions; also known as iso-<em>2</em>-cytochrome c; electron <em>2</em>-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers <em>2</em>-deoxyglucose resistance when overexpressed; DOG2 has a paralog 3,4-dihydroxy-<em>2</em>-butanone-4-phosphate synthase (DHBP synthase); required for riboflavin biosynthesis from lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires <em>2</em>- response to iron deprivation; transcription increases during iron deprivation and during treatment with <em>2</em>- (6-benzyl-<em>2</em>-pyridyl)quinazoline (BPQ) and copper; regulated by Aft1p and, to a lesser extent, by Aft2p required for high-affinity transport of proline; also transports the toxic proline analog azetidine-<em>2</em>- Lipid phosphate phosphatase; catalyzes Mg(<em>2</em>+)-independent dephosphorylation of phosphatidic acid (PA) Beta-adaptin; large subunit of the clathrin associated protein complex (AP-<em>2</em>); involved in vesicle mediated Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to <em>2</em>- condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form <em>2</em>- Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to <em>2</em>- Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct <em>2</em>' Zinc finger transcription factor involved in arginine-responsive genes; Zn(<em>2</em>)-Cys(6) binuclear cluster dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-<em>2</em>- Protein of unknown function; null mutant is resistant to <em>2</em>-deoxy-D-glucose and displays abnormally elongated v-SNARE component of vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca(<em>2</em>+ 6-phosphofructo-<em>2</em>-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[<em>2</em>] <em>2</em>-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-<em>2</em>-hydroxyglutarate Protein of unknown function that contains <em>2</em> PY motifs; ubiquinated by Rsp5p; overexpression confers resistance Alpha-isopropylmalate synthase (<em>2</em>-isopropylmalate synthase); the main isozyme responsible for the first membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-<em>2</em> synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor <em>2</em> Subunit <em>2</em> of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial plus-ends and stabilizes microtubules; required for mitotic spindle assembly, chromosome segregation, and <em>2</em> unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-<em>2</em>; Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)<em>2</em>-ceramide (M(IP)2C), the most Zinc finger transcription factor involved in multidrug resistance; Zn(<em>2</em>)-Cys(6) zinc finger transcription Transportin or cytosolic karyopherin beta <em>2</em>; functions in the rg-nuclear localization signal-mediated involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-<em>2</em> Putative protein of unknown function; similar to transcriptional regulators from the Zn[<em>2</em>]-Cys[6] binuclear sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa <em>2</em> ; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-<em>2</em>, Beta <em>2</em> subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic Mitochondrial <em>2</em>' O-ribose methyltransferase; required for methylation of U(2791) in 21S rRNA; MRM2 deletion <em>2</em>-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to Beta regulatory subunit of casein kinase <em>2</em> (CK2); a Ser/Thr protein kinase with roles in cell growth Beta' regulatory subunit of casein kinase <em>2</em> (CK2); a Ser/Thr protein kinase with roles in cell growth Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-<em>2</em> Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor <em>2</em>; double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-<em>2</em>- Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-<em>2</em>- control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-<em>2</em>, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor <em>2</em> Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor <em>2</em> proteins localize to the cytosol; identical to Pau22p; encodes two proteins that are translated from <em>2</em> a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)<em>2</em>, Pheromone-regulated protein; contains with <em>2</em> predicted transmembrane segments and an FF sequence, a motif tRNA(Ser) Um(44) <em>2</em>'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for <em>2</em>- Chaperone protein for translation factor eEF2; involved in biogenesis of eukaryotic Elongation Factor <em>2</em> Zinc finger transcription factor; contains a Zn(<em>2</em>)-Cys(6) binuclear cluster domain, positively regulates Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', <em>2</em>''-cyclic phosphate to ADP-ribose 1' Phosphoinositide PI4,5P(<em>2</em>) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a Vacuolar RNase of the T(<em>2</em>) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-<em>2</em> <em>2</em>-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis Alpha-isopropylmalate synthase II (<em>2</em>-isopropylmalate synthase); catalyzes the first step in the leucine duplication; localizes to the half-bridge of the spindle pole body (SPB); required for progression through G(<em>2</em>) Alpha catalytic subunit of casein kinase <em>2</em> (CK2); a Ser/Thr protein kinase with roles in cell growth ; one of three mitochondrially-encoded subunits; number of introns in different strains varies from <em>2</em> Putative transcriptional repressor with Zn(<em>2</em>)-Cys(6) finger; negatively regulates transcription in response with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on <em>2</em>% ribosome biogenesis and as a chaperone for nascent polypeptide chains in partnership with Ssz1p and SSb1/<em>2</em>; functions as both a GTPase-activating protein (GAP) that stimulates the hydrolysis of GTP bound to eIF-<em>2</em>, Nuclear pore-associated protein; component of TREX-<em>2</em> complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription H2A.Z (Htz1p) for chromatin-bound histone H2A; N-terminus can deliver H2A.Z-H2B dimer to DNA-(H3-H4)<em>2</em> Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and <em>2</em>- retromer-mediated pathway for recycling internalized cell-surface proteins; interacts with Trm7p for <em>2</em>' formation of small nucleolar ribonucleoprotein complexes that are required for rRNA processing and <em>2</em>' deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator <em>2</em> biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-<em>2</em>- biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-<em>2</em>- of vacuole size and acidity; binds negative (Fig4p) and positive (Fab1p) regulators of PtdIns(3,5)P(<em>2</em>) Phosphoinositide PI4,5P(<em>2</em>) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a to DNA replication stress; human CDC34 functionally complements the thermosensitivity of the cdc34-<em>2</em> Enolase I, a phosphopyruvate hydratase; catalyzes conversion of <em>2</em>-phosphoglycerate to phosphoenolpyruvate regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type <em>2</em> phosphatidylglycerol; mitochondrial outer membrane protein; ortholog of mammalian neutral sphingomyelinase type <em>2</em> preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/<em>2</em>- Enolase II, a phosphopyruvate hydratase; catalyzes conversion of <em>2</em>-phosphoglycerate to phosphoenolpyruvate Hexokinase isoenzyme <em>2</em>; phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-<em>2</em> complex shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, <em>2</em>- Global transcriptional regulator, component of SAGA, TREX-<em>2</em> complexes; interacts with RNA polymerase NADPH-dependent aldo-keto reductase; reduces multiple substrates including <em>2</em>-methylbutyraldehyde and Alpha' catalytic subunit of casein kinase <em>2</em> (CK2); CK2 is a Ser/Thr protein kinase with roles in cell remodelase; responsible for introducing ceramides into GPI anchors having a C26:0 fatty acid in sn-<em>2</em> Vps51p-Vps52p-Vps53p-Vps54p; human ortholog is implicated in progressive cerebello-cerebral atrophy type <em>2</em> filamentation with UPC2, up-regulating the expression of genes involved in filamentous growth; contains Zn[<em>2</em>] expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(<em>2</em>) Cu(+<em>2</em>)-transporting P-type ATPase; required for export of copper from cytosol into extracytosolic compartment , regulating activity, localization, and proteosomal degradation; homolog of mammalian lipins 1 and <em>2</em>; Damaged-DNA binding subunit of Nuclear Excision Repair Factor <em>2</em>; recognizes and binds damaged DNA with interaction with the Hmt1p methyltransferase; delays late firing of single copy origins by opposing the Fkh1/<em>2</em> internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its <em>2</em> Delta <em>2</em>-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of isopentenyladenosine upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type <em>2</em> CoQ and respiratory-chain deficiencies, and is mutated in autosomal-recessive cerebellar ataxia type <em>2</em> Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme <em>2</em>; involved in glycolysis and gluconeogenesis closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase <em>2</em>; the phosphatases Pph21p, Pph22p and Pph3p; has similarity to the N- and C-termini of N. crassa HAM-<em>2</em>; internalization and turnover of Ste2p, mating and zygote formation; recruits Rsp5p to Ste2p via its <em>2</em> activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(<em>2</em>) lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-<em>2</em> of filamentation with ECM22, up-regulating the expression of filamentous growth genes; contains a Zn[<em>2</em>] forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia <em>2</em> exonuclease; involved in 3'-end processing of U6 snRNA removing uridines and generating a terminal <em>2</em>& involved in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest via CLN1/<em>2</em> binding protein that recruits substrates to the proteasome; subunit of nuclear excision repair factor <em>2</em> methyl-base lesions; poly(rA)-binding protein affecting poly(A) tail length and mRNA stability; Fe(II)/<em>2</em>- shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-4 has a paralog, ASP3-<em>2</em>, they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced <em>2</em>- increases actin gliding, motor activity and ligand-induced endocytosis; contains proline-rich tail homology <em>2</em> ; phosphorylates and inactivates Orm1p/2p when sphingolipid synthesis is compromised; role in TORC1/<em>2</em>- ; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-<em>2</em> Protein involved in apoptosis; variously described as containing a BCL-<em>2</em> homology (BH3) domain or as ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent NHEJ pathway; controls <em>2</em>- localizes to the spindle, spindles poles, and detached KTs; CLASP family member homologous to human CLASP1/<em>2</em> Isoform <em>2</em> of <em>2</em>-acylglycerol O-acyltransferase <em>2</em> Isoform <em>2</em> of NEDD4-binding protein <em>2</em>-like <em>2</em> Isoform <em>2</em> of AP-<em>2</em> complex subunit alpha-<em>2</em> Isoform <em>2</em> of Cytoplasmic tRNA <em>2</em>-thiolation protein <em>2</em> <em>2</em>-Hydroxyacid oxidase <em>2</em> <em>2</em>-Hydroxyacid oxidase <em>2</em> dynamin-<em>2</em> isoform <em>2</em> Leucine aminopeptidase <em>2</em>-<em>2</em> presenilin-<em>2</em> isoform <em>2</em> synaptojanin-<em>2</em> isoform <em>2</em> <em>2</em>-Hydroxyacid oxidase <em>2</em> Leucine aminopeptidase <em>2</em>-<em>2</em> Isoform <em>2</em> of Polycystic kidney disease <em>2</em>-like <em>2</em> protein Isoform <em>2</em> of Nuclear factor erythroid <em>2</em>-related factor <em>2</em> Isoform <em>2</em> of Interferon regulatory factor <em>2</em>-binding protein <em>2</em> Isoform <em>2</em> of POU domain, class <em>2</em>, transcription factor <em>2</em> Isoform <em>2</em> of Procollagen-lysine,<em>2</em>-oxoglutarate 5-dioxygenase <em>2</em> Isoform <em>2</em> of N(<em>2</em>),N(<em>2</em>)-dimethylguanosine tRNA methyltransferase Isoform <em>2</em> of Nuclear receptor subfamily <em>2</em> group C member <em>2</em> Isoform <em>2</em> of 6-phosphofructo-<em>2</em>-kinase/fructose-2,6-biphosphatase <em>2</em> Isoform <em>2</em> of Tomoregulin-<em>2</em> Polycystin-<em>2</em>-like protein <em>2</em> <em>2</em>-hydroxyacyl-CoA lyase <em>2</em> <em>2</em>-hydroxyacyl-CoA lyase <em>2</em> Isoform <em>2</em> of Ankyrin-<em>2</em> Dicer-like protein <em>2</em>-<em>2</em> <em>2</em>-iminobutanoate/<em>2</em>-iminopropanoate deaminase Isoform <em>2</em> of Nidogen-<em>2</em> Isoform <em>2</em> of Intersectin-<em>2</em> Isoform <em>2</em> of Xylosyltransferase <em>2</em> Isoform <em>2</em> of Tropomodulin-<em>2</em> Bcl-<em>2</em>-like protein <em>2</em> Bcl-<em>2</em>-like protein <em>2</em> serine incorporator <em>2</em> isoform <em>2</em> Isoform <em>2</em> of Fibulin-<em>2</em> Isoform <em>2</em> of Mucolipin-<em>2</em> Isoform <em>2</em> of Calcipressin-<em>2</em> Isoform <em>2</em> of Cytohesin-<em>2</em> Isoform <em>2</em> of Caprin-<em>2</em> Fe(<em>2</em>+) transport protein <em>2</em> <em>2</em>-hydroxychromene-<em>2</em>-carboxylate isomerase <em>2</em>-hydroxychromene-<em>2</em>-carboxylate isomerase Isoform <em>2</em> of Nesprin-<em>2</em> Isoform <em>2</em> of Ficolin-<em>2</em> Isoform <em>2</em> of Latrophilin-<em>2</em> beta-arrestin-<em>2</em> isoform <em>2</em> Isoform <em>2</em> of Mitofusin-<em>2</em> Putative <em>2</em>-dehydropantoate <em>2</em>-reductase Type-<em>2</em> histone deacetylase <em>2</em> Isoform <em>2</em> of Nucleobindin-<em>2</em> Isoform <em>2</em> of Dynamin-<em>2</em> Isoform <em>2</em> of Ubinuclein-<em>2</em> Isoform <em>2</em> of Atlastin-<em>2</em> Bcl-<em>2</em>-like protein <em>2</em> Isoform <em>2</em> of Junctophilin-<em>2</em> Isoform <em>2</em> of Rhotekin-<em>2</em> <em>2</em>-hydroxyacyl-CoA lyase <em>2</em> Isoform <em>2</em> of Mitoferrin-<em>2</em> <em>2</em>-iminobutanoate/<em>2</em>-iminopropanoate deaminase Isoform <em>2</em> of Prominin-<em>2</em> Isoform <em>2</em> of Ataxin-<em>2</em> Vesicle-associated protein <em>2</em>-<em>2</em> Bcl-<em>2</em>-like protein <em>2</em> Isoform <em>2</em> of Pappalysin-<em>2</em> Isoform <em>2</em> of Calcyphosin-<em>2</em> Isoform <em>2</em> of Erlin-<em>2</em> <em>2</em>-acylglycerol O-acyltransferase <em>2</em> <em>2</em>-hydroxychromene-<em>2</em>-carboxylate isomerase Isoform <em>2</em> of Matrilin-<em>2</em> <em>2</em>-hydroxyacyl-CoA lyase <em>2</em> Isoform <em>2</em> of Caskin-<em>2</em> <em>2</em>-iminobutanoate/<em>2</em>-iminopropanoate deaminase Isoform <em>2</em> of Insulin-like growth factor <em>2</em> mRNA-binding protein <em>2</em> Isoform <em>2</em> of Voltage-dependent calcium channel subunit alpha-<em>2</em>/delta-<em>2</em> lipid phosphate phosphohydrolase <em>2</em> isoform <em>2</em> <em>2</em>-acylglycerol O-acyltransferase <em>2</em>-A Isoform <em>2</em> of Protein sidekick-<em>2</em> AP-<em>2</em> complex subunit alpha-<em>2</em> chondroitin sulfate synthase <em>2</em> isoform <em>2</em> anion exchange protein <em>2</em> isoform <em>2</em> Isoform <em>2</em> of Protein argonaute-<em>2</em> Isoform <em>2</em> of Pumilio homolog <em>2</em> Isoform <em>2</em> of Gamma-<em>2</em>-syntrophin Superkiller viralicidic activity <em>2</em>-like <em>2</em> serum paraoxonase/arylesterase <em>2</em> isoform <em>2</em> Isoform <em>2</em> of Asialoglycoprotein receptor <em>2</em> Protein disulfide-isomerase like <em>2</em>-<em>2</em> Isoform <em>2</em> of Inverted formin-<em>2</em> NEDD4-binding protein <em>2</em>-like <em>2</em> NEDD4-binding protein <em>2</em>-like <em>2</em> kelch-like protein <em>2</em> isoform <em>2</em> Myosin type-<em>2</em> heavy chain <em>2</em> cyclin-dependent kinase <em>2</em> isoform <em>2</em> kinesin light chain <em>2</em> isoform <em>2</em> Isoform <em>2</em> of Alanine aminotransferase <em>2</em> Isoform <em>2</em> of Phosphatidate cytidylyltransferase <em>2</em> Isoform <em>2</em> of ERI1 exoribonuclease <em>2</em> Isoform <em>2</em> of Putative adenosylhomocysteinase <em>2</em> neuroendocrine convertase <em>2</em> isoform <em>2</em> preproprotein AP-<em>2</em> complex subunit alpha-<em>2</em> AP-<em>2</em> complex subunit alpha-<em>2</em> myotubularin-related protein <em>2</em> isoform <em>2</em> Isoform <em>2</em> of Nodal modulator <em>2</em> Isoform <em>2</em> of Dynactin subunit <em>2</em> Isoform <em>2</em> of Zinc transporter <em>2</em> Isoform <em>2</em> of Protocadherin alpha-<em>2</em> fermitin family homolog <em>2</em> isoform <em>2</em> CAAX prenyl protease <em>2</em> isoform <em>2</em> Isoform <em>2</em> of Catenin alpha-<em>2</em> <em>2</em>-acylglycerol O-acyltransferase <em>2</em>-B calpain-<em>2</em> catalytic subunit isoform <em>2</em> Isoform <em>2</em> of Roundabout homolog <em>2</em> Cytoplasmic dynein <em>2</em> intermediate chain <em>2</em> Isoform <em>2</em> of Abl interactor <em>2</em> Isoform <em>2</em> of Ryanodine receptor <em>2</em> Isoform <em>2</em> of Dachshund homolog <em>2</em> rRNA <em>2</em>'-O-methyltransferase fibrillarin <em>2</em> Isoform <em>2</em> of Protein dopey-<em>2</em> mitochondrial <em>2</em>-oxodicarboxylate carrier isoform <em>2</em> protein NipSnap homolog <em>2</em> isoform <em>2</em> AP-<em>2</em> complex subunit alpha-<em>2</em> AP-<em>2</em> complex subunit alpha-<em>2</em> Isoform <em>2</em> of Deoxyribonuclease-<em>2</em>-beta Isoform <em>2</em> of Riboflavin transporter <em>2</em> Isoform <em>2</em> of Beta-arrestin-<em>2</em> Isoform <em>2</em> of Extended synaptotagmin-<em>2</em> Isoform <em>2</em> of GMP reductase <em>2</em> Isoform <em>2</em> of Glutaredoxin-<em>2</em>, mitochondrial SEC14-like protein <em>2</em> isoform <em>2</em> Protein disulfide isomerase-like <em>2</em>-<em>2</em> hyaluronan-binding protein <em>2</em> isoform <em>2</em> glucosidase <em>2</em> subunit beta isoform <em>2</em> Isoform <em>2</em> of Catenin delta-<em>2</em> Isoform <em>2</em> of Disabled homolog <em>2</em> Isoform <em>2</em> of Neuron navigator <em>2</em> Isoform <em>2</em> of Crumbs homolog <em>2</em> Isoform <em>2</em> of Ethanolamine kinase <em>2</em> Isoform <em>2</em> of Retinal dehydrogenase <em>2</em> Gigasin-<em>2</em> {ECO:0000303|Ref.<em>2</em>} LEM domain-containing protein <em>2</em> isoform <em>2</em> Cell division control protein <em>2</em> homolog <em>2</em> Isoform <em>2</em> of Protein patched homolog <em>2</em> <em>2</em>-oxoglutarate dehydrogenase, mitochondrial isoform <em>2</em> precursor Isoform <em>2</em> of Syntaxin-binding protein <em>2</em> DNA polymerase epsilon subunit <em>2</em> isoform <em>2</em> Isoform <em>2</em> of Protein Hook homolog <em>2</em> Isoform <em>2</em> of Homer protein homolog <em>2</em> Isoform <em>2</em> of Protein DDI1 homolog <em>2</em> Interferon regulatory factor <em>2</em>-binding protein <em>2</em> Isoform <em>2</em> of RING-box protein <em>2</em> Alanine--glyoxylate aminotransferase <em>2</em> homolog <em>2</em>, mitochondrial Isoform <em>2</em> of Endoplasmic reticulum aminopeptidase <em>2</em> Isoform <em>2</em> of Inorganic pyrophosphatase <em>2</em>, mitochondrial Isoform <em>2</em> of Slit homolog <em>2</em> protein Isoform <em>2</em> of Nicotinamide mononucleotide adenylyltransferase <em>2</em> Isoform <em>2</em> of Myelin expression factor <em>2</em> Isoform <em>2</em> of Copper-transporting ATPase <em>2</em> Cyclin-dependent kinase <em>2</em>-associated protein <em>2</em> Isoform <em>2</em> of Diphosphoinositol polyphosphate phosphohydrolase <em>2</em> pyruvate dehydrogenase kinase, isozyme <em>2</em> isoform <em>2</em> Isoform <em>2</em> of Muscleblind-like protein <em>2</em> Isoform <em>2</em> of Nucleoredoxin-like protein <em>2</em> <em>2</em>-hydroxy-6-oxononadienedioate/<em>2</em>-hydroxy-6-oxononatrienedioate hydrolase <em>2</em> {ECO:0000255|HAMAP-Rule:MF Isoform <em>2</em> of Tau-tubulin kinase <em>2</em> Isoform <em>2</em> of Fermitin family homolog <em>2</em> POU domain, class <em>2</em>, transcription factor <em>2</em> Cell division control protein <em>2</em> homolog <em>2</em> Isoform <em>2</em> of mRNA-decapping enzyme <em>2</em> Isoform <em>2</em> of Pantothenate kinase <em>2</em>, mitochondrial Isoform <em>2</em> of YY1-associated factor <em>2</em> Isoform <em>2</em> of Clathrin heavy chain <em>2</em> Delta(1)-pyrroline-<em>2</em>-carboxylate reductase <em>2</em> Eukaryotic translation initiation factor <em>2</em> subunit <em>2</em> Isoform <em>2</em> of Elongator complex protein <em>2</em> Cyclin-dependent kinase <em>2</em>-associated protein <em>2</em> Eukaryotic translation initiation factor <em>2</em> subunit <em>2</em> Isoform <em>2</em> of Chromobox protein homolog <em>2</em> Isoform <em>2</em> of Angiomotin-like protein <em>2</em> Isoform <em>2</em> of Smoothelin-like protein <em>2</em> Procollagen-lysine,<em>2</em>-oxoglutarate 5-dioxygenase <em>2</em> Procollagen-lysine,<em>2</em>-oxoglutarate 5-dioxygenase <em>2</em> Isoform <em>2</em> of CWF19-like protein <em>2</em> Isoform <em>2</em> of Beta-1,4-galactosyltransferase <em>2</em> Cell division control protein <em>2</em> homolog <em>2</em> Eukaryotic translation initiation factor <em>2</em> subunit <em>2</em> Eukaryotic translation initiation factor <em>2</em> subunit <em>2</em> betaine--homocysteine S-methyltransferase <em>2</em> isoform <em>2</em> Isoform <em>2</em> of Transcriptional adapter <em>2</em>-alpha Isoform <em>2</em> of Tyrosyl-DNA phosphodiesterase <em>2</em> Isoform <em>2</em> of Lipase maturation factor <em>2</em> Isoform <em>2</em> of Protein diaphanous homolog <em>2</em> Isoform <em>2</em> of D(<em>2</em>) dopamine receptor Isoform <em>2</em> of Protein angel homolog <em>2</em> Isoform <em>2</em> of DIS3-like exonuclease <em>2</em> Isoform <em>2</em> of 5'-3' exoribonuclease <em>2</em> Isoform <em>2</em> of Cohesin subunit SA-<em>2</em> Isoform <em>2</em> of Storkhead-box protein <em>2</em> Isoform <em>2</em> of GTP-binding protein <em>2</em> Isoform <em>2</em> of Transcriptional adapter <em>2</em>-beta Isoform <em>2</em> of Indoleamine 2,3-dioxygenase <em>2</em> Isoform <em>2</em> of Piwi-like protein <em>2</em> glutathione S-transferase omega-<em>2</em> isoform <em>2</em> Eukaryotic translation initiation factor <em>2</em> subunit <em>2</em> Isoform <em>2</em> of Prospero homeobox protein <em>2</em> Isoform <em>2</em> of Epidermal retinol dehydrogenase <em>2</em> Isoform <em>2</em> of Ribose-phosphate pyrophosphokinase <em>2</em> Isoform <em>2</em> of ELAV-like protein <em>2</em> Isoform <em>2</em> of Diacylglycerol O-acyltransferase <em>2</em> Isoform <em>2</em> of Sugar phosphate exchanger <em>2</em> Isoform <em>2</em> of Lipid phosphate phosphohydrolase <em>2</em> Isoform <em>2</em> of Inactive rhomboid protein <em>2</em> Isoform <em>2</em> of DNA topoisomerase <em>2</em>-alpha Isoform <em>2</em> of Fatty acid desaturase <em>2</em> Isoform <em>2</em> of TOM1-like protein <em>2</em> Isoform <em>2</em> of Folliculin-interacting protein <em>2</em> Isoform <em>2</em> of Adenylate kinase <em>2</em>, mitochondrial Isoform <em>2</em> of RIMS-binding protein <em>2</em> <em>2</em>-oxoisovalerate dehydrogenase subunit alpha <em>2</em>, mitochondrial Cyclin-dependent kinase <em>2</em>-associated protein <em>2</em> Mite group <em>2</em> allergen Lep d <em>2</em> Mite group <em>2</em> allergen Pso o <em>2</em> Interferon regulatory factor <em>2</em>-binding protein <em>2</em> Interferon regulatory factor <em>2</em>-binding protein <em>2</em> Structural maintenance of chromosomes protein <em>2</em>-<em>2</em> programmed cell death protein <em>2</em> isoform <em>2</em> glutathione S-transferase Mu <em>2</em> isoform <em>2</em> Isoform <em>2</em> of Bromodomain-containing protein <em>2</em> <em>2</em>-oxoisovalerate dehydrogenase subunit beta <em>2</em>, mitochondrial Isoform <em>2</em> of Disks large homolog <em>2</em> POU domain, class <em>2</em>, transcription factor <em>2</em> Isoform <em>2</em> of Antigen peptide transporter <em>2</em> Isoform <em>2</em> of GLIPR1-like protein <em>2</em> Isoform <em>2</em> of DCN1-like protein <em>2</em> Isoform <em>2</em> of CLIP-associating protein <em>2</em> Isoform <em>2</em> of Polyadenylate-binding protein <em>2</em> Eukaryotic translation initiation factor <em>2</em> subunit <em>2</em> Isoform <em>2</em> of Extracellular sulfatase Sulf-<em>2</em> Isoform <em>2</em> of Protein canopy homolog <em>2</em> Isoform <em>2</em> of FGFR1 oncogene partner <em>2</em>