Young Adult male dpy-5;him-8 miRNA expression change
miRNA expression change dpy-5;him-8 young adult male (Waterston project, Slack subgroup)
small RNAs (<200bp) were isolated from N2 young adult males, and sequenced using Illumina technology. We show changes in expression levels for each miRNA feature.
Series DescriptionWe report a significant number of miRNAs and other non-coding small RNAs show dramatic changes in expression during aging in C. elegans. RNAs were prepared from four diffrent timepoints during adulthood of C. elegans hermaphrodites, Day 0, 5, 8 and 12 post-L4 molt, and used for making cDNA libraries for small RNAs. Each library was sequenced using recent advances in high-throughput sequencing technology, Solexa. This study should lead to a better understanding of the aging process and age-related diseases.
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Release Date: 2010-02-13