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WormBase Tree Display for Gene: WBGene00000053

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Name Class

WBGene00000053SMapS_parentSequenceT05C12
IdentityVersion1
NameCGC_nameacr-14Person_evidenceWBPerson1430
Sequence_nameT05C12.2
Molecular_nameT05C12.2
T05C12.2.1
CE25099
Other_nameCELE_T05C12.2Accession_evidenceNDBBX284602
Public_nameacr-14
DB_infoDatabaseAceViewgene2I462
WormQTLgeneWBGene00000053
WormFluxgeneWBGene00000053
NDBlocus_tagCELE_T05C12.2
PanthergeneCAEEL|WormBase=WBGene00000053|UniProtKB=Q22224
familyPTHR18945
NCBIgene191601
RefSeqproteinNM_063315.3
TrEMBLUniProtAccQ22224
UniProt_GCRPUniProtAccQ22224
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:19WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classacr
Allele (30)
StrainWBStrain00031836
RNASeq_FPKM (74)
GO_annotation (28)
Ortholog (36)
Paralog (100)
Structured_descriptionConcise_descriptionacr-14 encodes a protein that contains neurotransmitter-gated ion-channel ligand-binding and transmembrane domains.Curator_confirmedWBPerson48
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection and synapse. Expressed in intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lewy body dementia; carcinoma (multiple); and inflammatory bowel disease (multiple). Is an ortholog of human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:3908Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:3748Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:8778Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:3083Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:12217Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:8577Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:1324Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:7474Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
DOID:5419Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1960)
Molecular_infoCorresponding_CDST05C12.2
Corresponding_transcriptT05C12.2.1
Other_sequenceJI180092.1
Associated_featureWBsf223455
WBsf223456
Experimental_infoRNAi_resultWBRNAi00066388Inferred_automaticallyRNAi_primary
WBRNAi00097922Inferred_automaticallyRNAi_primary
WBRNAi00052489Inferred_automaticallyRNAi_primary
WBRNAi00018218Inferred_automaticallyRNAi_primary
WBRNAi00078345Inferred_automaticallyRNAi_primary
WBRNAi00035191Inferred_automaticallyRNAi_primary
Expr_patternChronogram1906
Expr4858
Expr8203
Expr10607
Expr13428
Expr1018728
Expr1156115
Expr2009181
Expr2027420
Drives_construct (11)
Construct_productWBCnstr00016680
WBCnstr00037766
Microarray_results (20)
Expression_cluster (91)
Interaction (28)
Map_infoMapIIPosition0.742235Error0.001179
PositivePositive_cloneT05C12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4965
4646
5546
Pseudo_map_position
Reference (26)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene