WormBase Tree Display for Gene: WBGene00001864

WBGene00001864 SMap: S_parent: Sequence: D1086
  Identity: Version: 2
    Name: CGC_name: him-5 Person_evidence: WBPerson261
      Sequence_name: D1086.4
      Molecular_name: D1086.4a
        D1086.4a.1
        CE09062
        D1086.4b
        CE45310
        D1086.4b.1
      Other_name: CELE_D1086.4 Accession_evidence: NDB BX284605
      Public_name: him-5
    DB_info: Database: WormQTL gene WBGene00001864
        WormFlux gene WBGene00001864
        NDB locus_tag CELE_D1086.4
        NCBI gene 183932
        RefSeq protein NM_001269627.3
            NM_001269626.2
        TrEMBL UniProtAcc O17724
            E1B6V2
        UniProt_GCRP UniProtAcc O17724
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 22 Aug 2008 17:09:12 WBPerson2970 Event: Acquires_merge: WBGene00008391
              Name_change: Sequence_name: D1086.4
      Acquires_merge: WBGene00008391
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: him
    Reference_allele: WBVar00144023
    Allele (43)
    Legacy_information: e1467ts : at 20x self-progeny 16% XO male 11% ova are nullo-X as a result of reductional meiotic nondisjunction; X chromosome recombination specifically reduced 50%. ES3 (progeny). ME3. NA2 (e1490 (stronger allele : 33% Him at 20x)).
      See also e1467, e1490
      [C.elegansII] e1467ts : at 20C self-progeny 16% XO male, 3% 3X herm, 11% ova are nullo-X as a result of reductional meiotic nondisjunction; X chromosome recombination specifically reduced 50% or more, except at left end (increased); additional sterility not due to autosomal nondisjunction ( brood reduced 64% at 25C); some embryonic lethality. ES3 (progeny). ME3. OA4: e1490 (stronger allele : 33% Him at 20C)). Cloned: cosmid rescue K02A12. [Hodgkin et al. 1979; Broverman and Meneely 1994; FH]
    Strain (490)
    RNASeq_FPKM (74)
    GO_annotation: 00008104
      00030516
      00030517
      00030518
    Ortholog: chrV_pilon.g16429 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: him-5 was identified in screens for genes that when mutated resulted in an increased frequency of X chromosome nondisjunction and thus, an increased frequency of genotypically XO males in self-fertile populations; him-5 functions in X chromosome dynamics by regulating the number and distribution of X chromosome pairing events. Paper_evidence: WBPaper00000179
            WBPaper00001852
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Oct 2010 00:00:00
      Automated_description: Involved in meiotic DNA double-strand break formation involved in reciprocal meiotic recombination and meiotic chromosome segregation. Located in condensed chromosome. Expressed in gonad. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: D1086.4a
      D1086.4b
    Corresponding_transcript: D1086.4a.1
      D1086.4b.1
    Associated_feature: WBsf647510
      WBsf232867
      WBsf232868
      WBsf232869
  Experimental_info: RNAi_result: WBRNAi00030368 Inferred_automatically: RNAi_primary
      WBRNAi00111474 Inferred_automatically: RNAi_primary
      WBRNAi00012552 Inferred_automatically: RNAi_primary
      WBRNAi00061770 Inferred_automatically: RNAi_primary
      WBRNAi00043422 Inferred_automatically: RNAi_primary
      WBRNAi00111473 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr9917
      Expr1023729
      Expr1031097
      Expr1147415
      Expr2012430
      Expr2030666
    Drives_construct: WBCnstr00036641
      WBCnstr00038151
    Construct_product: WBCnstr00036641
      WBCnstr00038150
      WBCnstr00038151
    Microarray_results (18)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045861:wdr-5(ok1417)_downregulated
      WBPaper00048762:FOG-3_associated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00050015:ifg-1(RNAi)_downregulated
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_upregulated_WT_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Metformin_downregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057083:daf-2(e1370)rsks-1(ok1255)_post-transcriptional_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:mex-1(or286)_downregulated
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058886:anp-1(ok608)_downregulated
      WBPaper00059378:lmn-1(Y59C)_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061203:let-418(n3536)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:Germline
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:T22D1.5-inx-14
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064716:paraquat_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065199:Transgeneration-starvation_regulated_fed
      WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025032:cluster_41
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp2
      WBPaper00033101:spr-5_regulated
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037611:GLD-2-associated
      WBPaper00037611:RNP-8-associated
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_E
      [cgc6390]:oogenesis-enriched
    Interaction (68)
  Map_info: Map: V Position: 6.09216 Error: 0.018285
    Well_ordered
    Positive: Positive_clone: D1086 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 308
        6177
      Multi_point (33)
      Pos_neg_data: 1761
        4301
        6866
        7401
    Landmark_gene
  Reference (239)
  Remark: This locus was previously connected to Y54G2A.1 which was a mistake [030212 krb]
  Method: Gene