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WormBase Tree Display for Gene: WBGene00002232

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Name Class

WBGene00002232SMapS_parentSequenceF11A6
IdentityVersion1
NameCGC_namekpc-1Person_evidenceWBPerson533
Sequence_nameF11A6.1
Molecular_nameF11A6.1a
F11A6.1a.1
CE17653
F11A6.1a.2
F11A6.1b
Other_nameCELE_F11A6.1Accession_evidenceNDBBX284601
Public_namekpc-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:27WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classkpc
Allele (115)
StrainWBStrain00035504
RNASeq_FPKM (74)
GO_annotation (48)
Ortholog (49)
ParalogWBGene00000088Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00000254Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00001172Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00017686Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionkpc-1 encodes two isoforms of a Kex2/subtilisin-like proprotein convertase that is a member of the subtilase family of calcium-dependent serine endoproteinases that includes mammalian furin (OMIM:136950) and Saccharomyces cerevisiae Kex2p; KPC-1 is required for normal growth and locomotion and is likely responsible for the processing of transforming growth factor (TGF) beta proproteins encoded by daf-7, dbl-1, and unc-129.Paper_evidenceWBPaper00004142
WBPaper00018607
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables serine-type endopeptidase activity and signaling receptor binding activity. Involved in several processes, including neuron development; positive regulation of developmental process; and protein processing. Located in neuronal cell body. Expressed in several structures, including PVD; epithelial cell; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in arteriosclerosis; colon adenocarcinoma; and colorectal adenocarcinoma. Is an ortholog of human FURIN (furin, paired basic amino acid cleaving enzyme).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:234Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8747)
DOID:2349Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8568)
DOID:0050861Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8746)
Molecular_infoCorresponding_CDSF11A6.1a
Corresponding_CDS_historyF11A6.1b:wp245
Corresponding_transcriptF11A6.1b
F11A6.1a.1
F11A6.1a.2
Other_sequence (36)
Associated_feature (22)
Experimental_infoRNAi_resultWBRNAi00116836Inferred_automaticallyRNAi_primary
WBRNAi00003363Inferred_automaticallyRNAi_primary
WBRNAi00089035Inferred_automaticallyRNAi_primary
WBRNAi00106792Inferred_automaticallyRNAi_primary
WBRNAi00044358Inferred_automaticallyRNAi_primary
WBRNAi00027714Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00018109
WBCnstr00018110
WBCnstr00020063
Construct_productWBCnstr00018110
WBCnstr00018228
WBCnstr00019277
WBCnstr00043014
Microarray_results (39)
Expression_cluster (198)
Interaction (29)
Map_infoMapIPosition9.53611Error0.019245
PositivePositive_cloneF11A6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4460
4467
Pseudo_map_position
Reference (28)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene