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WormBase Tree Display for Gene: WBGene00003008

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Name Class

WBGene00003008SMapS_parentSequenceY54G2A
IdentityVersion1
NameCGC_namelin-22Person_evidenceWBPerson261
Sequence_nameY54G2A.1
Molecular_nameY54G2A.1
Y54G2A.1.1
CE26703
Other_namehlh-9Person_evidenceWBPerson346
4D656Accession_evidenceEMBLAF304120
CELE_Y54G2A.1Accession_evidenceNDBBX284604
Public_namelin-22
DB_infoDatabaseAceViewgene4D787
WormQTLgeneWBGene00003008
WormFluxgeneWBGene00003008
NDBlocus_tagCELE_Y54G2A.1
PanthergeneCAEEL|WormBase=WBGene00003008|UniProtKB=G5EF76
familyPTHR10985
NCBIgene177082
RefSeqproteinNM_067880.6
SwissProtUniProtAccG5EF76
UniProt_GCRPUniProtAccG5EF76
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlin
Reference_alleleWBVar00089461
Allele (74)
Legacy_informationn372 : V1-V4 divide like V5 resulting in multiple ectopic postdeirids in hermaphrodites and males and multiple ectopic rays in males. Males also have hermaphroditic Pn.p's and are mostly missing lateral alae. ES1 (hermaphrodite) ES2 (male). ME2. NA1.
See also n372, n1113
Strain (12)
RNASeq_FPKM (74)
GO_annotation (17)
Ortholog (25)
ParalogWBGene00001964Caenorhabditis elegansFrom_analysisPanther
WBGene00001966Caenorhabditis elegansFrom_analysisPanther
Structured_descriptionConcise_descriptionlin-22 encodes a basic helix-loop-helix (bHLH)-containing protein that is homologous to the Drosophila hairy/Enhancer of split transcriptional repressors; during postembryonic development, lin-22 activity is required for patterning of midbody epidermal and neuronal lineages.Paper_evidenceWBPaper00000978
WBPaper00002844
Curator_confirmedWBPerson1843
Date_last_updated09 Aug 2005 00:00:00
Automated_descriptionPredicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anterior/posterior pattern specification; negative regulation of gene expression; and nematode male tail tip morphogenesis. Acts upstream of or within epidermal cell fate specification. Predicted to be located in nucleus. Expressed in seam cell. Human ortholog(s) of this gene implicated in hemangiopericytoma. Is an ortholog of human HES1 (hes family bHLH transcription factor 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Disease_infoPotential_modelDOID:264Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:5192)
Molecular_infoCorresponding_CDSY54G2A.1
Corresponding_transcriptY54G2A.1.1
Other_sequenceEX916391.1
Hbac_isotig05734
EG025731.1
HBC05050_1
HBC04228_1
Associated_featureWBsf660013
WBsf718055
WBsf718056
WBsf978797
WBsf1026934
WBsf1026935
WBsf1026936
Transcription_factorWBTranscriptionFactor000727
Experimental_infoRNAi_resultWBRNAi00057436Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_constructWBCnstr00004218
WBCnstr00036289
WBCnstr00039720
WBCnstr00039721
WBCnstr00039722
WBCnstr00039723
Construct_productWBCnstr00016691
WBCnstr00016896
WBCnstr00036289
Regulate_expr_clusterWBPaper00053295:lin-22(icb38)_downregulated
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053295:lin-22(ot267)_downregulated
WBPaper00053295:lin-22(ot267)_upregulated
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053295:lin-22(ot269)_upregulated
Microarray_results (22)
Expression_cluster (63)
Interaction (101)
Map_infoMapIVPosition-6.65585Error0.044343
Well_ordered
PositivePositive_cloneY54G2AInferred_automaticallyFrom sequence, transcript, pseudogene data
Y94H6
Mapping_dataMulti_point683
684
691
Reference (147)
RemarkThe attached sequence (Y54G2A.1) was previously connected to him-5 by mistake [030212 krb]
MethodGene