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WormBase Tree Display for Gene: WBGene00003056

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Name Class

WBGene00003056SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namelon-2Person_evidenceWBPerson261
Sequence_nameC39E6.1
Molecular_nameC39E6.1
C39E6.1.1
CE35426
Other_nameCELE_C39E6.1Accession_evidenceNDBBX284606
Public_namelon-2
DB_infoDatabaseAceViewgeneXF356
WormQTLgeneWBGene00003056
WormFluxgeneWBGene00003056
NDBlocus_tagCELE_C39E6.1
PanthergeneCAEEL|WormBase=WBGene00003056|UniProtKB=Q18530
familyPTHR10822
NCBIgene180750
RefSeqproteinNM_076411.8
TREEFAMTREEFAM_IDTF353541
TrEMBLUniProtAccQ18530
UniProt_GCRPUniProtAccQ18530
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlon
Reference_alleleWBVar00143398
Allele (213)
Legacy_informatione678 : about 50% longer than wildtype at all stages. ES3. Male bursa slightly elongated ME3 (ME0 at 25x?). NA5 (e405 e434 etc. : similar phenotype to e678).
[C.elegansII] e678 : about 50% longer than wildtype at all stages; some embryonic lethality; ES3. Male bursa slightly elongated, ME3 (ME0 at25C?). OA4: e405, e434, n1346, n1630 etc. (allsimilar to e678). [Brenner 1974]
Strain (224)
RNASeq_FPKM (74)
GO_annotation (19)
Ortholog (25)
Structured_descriptionConcise_descriptionlon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface.Paper_evidenceWBPaper00029002
Curator_confirmedWBPerson1843
Date_last_updated24 Jan 2007 00:00:00
Automated_descriptionEnables growth factor binding activity. Involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of cell migration; and regulation of mesodermal cell fate specification. Located in cell surface. Expressed in hypodermis and intestine.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC39E6.1
Corresponding_CDS_historyC39E6.1:wp107
Corresponding_transcriptC39E6.1.1
Other_sequenceCRC07010_1
CR09868
CGC00490_1
CBC13859_1
CJC03031_1
CRC04307_1
Associated_feature (15)
Experimental_infoRNAi_result (23)
Expr_patternExpr4651
Expr4652
Expr12191
Expr1011265
Expr1031435
Expr1146202
Expr2013244
Expr2031475
Drives_constructWBCnstr00012150
WBCnstr00012151
WBCnstr00021097
WBCnstr00021479
WBCnstr00036259
Construct_productWBCnstr00012151
WBCnstr00021471
WBCnstr00021474
WBCnstr00021479
WBCnstr00036259
Microarray_results (21)
Expression_clusterWBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:intestine_larva_enriched
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00044736:flat_dev_expression
WBPaper00045521:Oogenic
WBPaper00045571:germline-ablation_upregulated
WBPaper00045729:gld-2(RNAi)_downregulated
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00045974:NSM_enriched_totalRNA_tiling
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049942:HeatShock_upregulated_hsf-1(+)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050080:rbr-2(tm3141)_upregulated
WBPaper00050094:mes-6(bn66)_downregulated
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:intestine_enriched
WBPaper00050990:intestine_expressed
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster3
WBPaper00053599:female_vs_male_upregulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00055386:daf-2(e1370)_downregulated
WBPaper00056826:hmc_biased
WBPaper00057006:DietaryRestriction_downregulated
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058948:PA14_downregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061340:ADE
WBPaper00061340:AFD
WBPaper00061340:AIN
WBPaper00061340:ALA
WBPaper00061340:AVA
WBPaper00061340:AVB
WBPaper00061340:AVD
WBPaper00061340:AVH
WBPaper00061340:AVJ
WBPaper00061340:AWB
WBPaper00061340:DA_DB
WBPaper00061340:DVA
WBPaper00061340:g1A
WBPaper00061340:g1A_g1P
WBPaper00061340:g1A_parent
WBPaper00061340:g2
WBPaper00061340:g2_parent
WBPaper00061340:I2_grandparent
WBPaper00061340:M4_parent
WBPaper00061340:MC
WBPaper00061340:Neuroblast_I6_M5
WBPaper00061340:Neuroblast_M2_M3
WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
WBPaper00061340:Parent_of_g1P_I3
WBPaper00061340:Parent_of_MI_pm1DR
WBPaper00061340:Parent_of_PVP_and_rect_V
WBPaper00061340:Pharyngeal_neuron
WBPaper00061340:PVP
WBPaper00061340:RID
WBPaper00061340:RME
WBPaper00061340:RMED
WBPaper00061527:cfz-2_18944-cfz-2_2268
WBPaper00061527:utx-1_2886-swan-1_2192
WBPaper00061651:AVJ_enriched
WBPaper00061651:I6_enriched
WBPaper00061651:NSM_enriched
WBPaper00061651:RIG_enriched
WBPaper00061651:VC_4_5_enriched
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065120:body-muscle-transcriptome
WBPaper00065841:19_0
WBPaper00065841:23_0
WBPaper00065841:36_0
WBPaper00065841:36_3
WBPaper00065841:44_0
WBPaper00065841:44_1
WBPaper00065841:60_0
WBPaper00065841:68_0
WBPaper00065841:87_0
WBPaper00065841:135_0
WBPaper00065841:145_0
WBPaper00065975:P-body_vs_oocyte_enriched
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066038:mip-1(how5)_downregulated
WBPaper00066110:Doxorubicin_downregulated_diploid
WBPaper00025141:unc-4::GFP_Enriched_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00029437:dcr-1_upregulated
WBPaper00030839:Embryo_A_Class
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00030985:Photorhabdus_luminescens_downregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00032165:differentially_expressed_with_age_medoid_3
WBPaper00035084:embryo_enriched_AIN-2_IP
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00036286:Pattern_D
WBPaper00037611:GLD-2-associated
WBPaper00037611:RNP-8-associated
WBPaper00040876:mir-35_upregulated
WBPaper00040985:AIN-2_asynchronous_intestine
WBPaper00040985:AIN-2_L4_intestine
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
Interaction (24)
Map_infoMapXPosition-6.74013Error0.007834
Well_ordered
PositiveInside_rearrmnDp30
yDp4
Positive_cloneC39E6Inferred_automaticallyFrom sequence, transcript, pseudogene data
F43C9
NegativeOutside_rearrmcDf2
Mapping_data2_point (57)
Multi_point (150)
Pos_neg_data (31)
Landmark_gene
Reference (155)
Remarksequence wsa incorrectly given as F43C9.3
MethodGene