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WormBase Tree Display for Gene: WBGene00003056

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Name Class

WBGene00003056SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namelon-2Person_evidenceWBPerson261
Sequence_nameC39E6.1
Molecular_nameC39E6.1
C39E6.1.1
CE35426
Other_nameCELE_C39E6.1Accession_evidenceNDBBX284606
Public_namelon-2
DB_infoDatabaseAceViewgeneXF356
WormQTLgeneWBGene00003056
WormFluxgeneWBGene00003056
NDBlocus_tagCELE_C39E6.1
PanthergeneCAEEL|WormBase=WBGene00003056|UniProtKB=Q18530
familyPTHR10822
NCBIgene180750
RefSeqproteinNM_076411.8
TREEFAMTREEFAM_IDTF353541
TrEMBLUniProtAccQ18530
UniProt_GCRPUniProtAccQ18530
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlon
Reference_alleleWBVar00143398
Allele (213)
Legacy_informatione678 : about 50% longer than wildtype at all stages. ES3. Male bursa slightly elongated ME3 (ME0 at 25x?). NA5 (e405 e434 etc. : similar phenotype to e678).
[C.elegansII] e678 : about 50% longer than wildtype at all stages; some embryonic lethality; ES3. Male bursa slightly elongated, ME3 (ME0 at25C?). OA4: e405, e434, n1346, n1630 etc. (allsimilar to e678). [Brenner 1974]
Strain (224)
RNASeq_FPKM (74)
GO_annotation (19)
Ortholog (25)
Structured_descriptionConcise_descriptionlon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface.Paper_evidenceWBPaper00029002
Curator_confirmedWBPerson1843
Date_last_updated24 Jan 2007 00:00:00
Automated_descriptionEnables growth factor binding activity. Involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of cell migration; and regulation of mesodermal cell fate specification. Located in cell surface. Expressed in hypodermis and intestine.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC39E6.1
Corresponding_CDS_historyC39E6.1:wp107
Corresponding_transcriptC39E6.1.1
Other_sequenceCRC07010_1
CR09868
CGC00490_1
CBC13859_1
CJC03031_1
CRC04307_1
Associated_feature (15)
Experimental_infoRNAi_result (23)
Expr_patternExpr4651
Expr4652
Expr12191
Expr1011265
Expr1031435
Expr1146202
Expr2013244
Expr2031475
Drives_constructWBCnstr00012150
WBCnstr00012151
WBCnstr00021097
WBCnstr00021479
WBCnstr00036259
Construct_productWBCnstr00012151
WBCnstr00021471
WBCnstr00021474
WBCnstr00021479
WBCnstr00036259
Microarray_results (21)
Expression_cluster (142)
Interaction (24)
Map_infoMapXPosition-6.74013Error0.007834
Well_ordered
PositiveInside_rearrmnDp30
yDp4
Positive_cloneC39E6Inferred_automaticallyFrom sequence, transcript, pseudogene data
F43C9
NegativeOutside_rearrmcDf2
Mapping_data2_point (57)
Multi_point161
164
165
166
167
168
169
170
171
173
177
230
277
278
280
281
282
357
358
359
393
395
410
415
416
417
419
421
422
423
424
442
531
532
533
534
535
536
551
552
582
587
612
618
619
644
645
646
731
732
789
793
794
880
916
1194
1204
1207
1208
1212
1213
2289
1319
1320
1321
1322
1328
1339
1342
1346
1353
1369
1540
1546
1547
1550
1551
1582
1588
1739
2005
2087
2112
2171
2227
2228
2229
2230
2231
2232
2233
2234
2290
2291
2292
2428
2441
2442
2453
2461
3243
3272
3283
3293
3322
3323
3378
3516
3525
3538
3539
3540
3582
3583
3606
3607
3645
3646
3652
3690
3691
3693
3695
3696
3698
3710
3711
3805
3815
3819
3849
3870
3973
3974
3997
4061
4095
4110
4111
4112
4113
4493
4784
4794
4795
5084
5465
5472
5702
5703
Pos_neg_data (31)
Landmark_gene
Reference (155)
Remarksequence wsa incorrectly given as F43C9.3
MethodGene