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WormBase Tree Display for Gene: WBGene00004350

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Name Class

WBGene00004350SMapS_parentSequenceF56B6
IdentityVersion2
NameCGC_namergs-7Person_evidenceWBPerson330
Sequence_nameF56B6.2
Molecular_name (25)
Other_nameCELE_F56B6.2Accession_evidenceNDBBX284606
Public_namergs-7
DB_infoDatabaseAceViewgeneXE175
WormQTLgeneWBGene00004350
WormFluxgeneWBGene00004350
NDBlocus_tagCELE_F56B6.2
PanthergeneCAEEL|WormBase=WBGene00004350|UniProtKB=Q8WQC0
familyPTHR10845
NCBIgene180645
RefSeqmRNANM_001038462.1
NM_001047792.2
NM_001029544.3
NM_001129681.2
NM_001129682.2
NM_001029543.2
NM_076209.4
proteinNP_001123153.1
NP_001024715.1
NP_001024714.1
NP_508610.3
NP_001041257.1
NP_001033551.1
NP_001123154.1
SwissProtUniProtAccQ8WQC0
TrEMBLUniProtAccQ1W0R0
H2KYQ7
H2KYQ4
H2KYQ8
OMIMgene600323
600861
602189
602514
602516
603276
607189
607190
607192
612407
disease145500
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:35WBPerson1971EventImportedInitial conversion from geneace
203 Dec 2004 16:13:27WBPerson2970EventAcquires_mergeWBGene00018936
Acquires_mergeWBGene00018936
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classrgs
Allele (191)
StrainLX658
LX677
RB1937
RNASeq_FPKM (74)
GO_annotation00015454
00015455
00015456
00015457
00071055
00071056
00071057
Ortholog (51)
Paralog (12)
Structured_descriptionProvisional_descriptionThe C2 domain is predicted to be a Ca(2+) and phospholipid binding site, is required in cell cultures for full inhibitory activity of RGS-7, and binds mammalian and C. elegans G[alpha]q subunits. The RGS domain binds mammalian and C. elegans G[alpha]i/o and G[alpha]q subunits (e.g., GOA-1 and EGL-30).
rgs-7 encodes three isoforms of an atypical regulator of G protein signaling (RGS) protein that contains both a C2 and an RGS domain, and that binds EGL-30 via both domains, similar in organization to mammalian PDZ-RGS3; the RGS domain has GTPase activator protein (GAP) activity in vitro on mammalian G[alphai]3; RGS-7 thus may stably bind EGL-30 at all stages of EGL-30's GTPase cycle, might organize EGL-30 into a stable multiprotein signalling complex (with GTP[gamma]S), and might persistently inhibit EGL-30 when triggered by calcium or phospholipids; rgs-7 has no obvious function in mass RNAi assaysPaper_evidenceWBPaper00005654
WBPaper00005958
WBPaper00013066
Curator_confirmedWBPerson567
Date_last_updated18 Jun 2007 00:00:00
Concise_descriptionrgs-7 encodes three isoforms of an atypical regulator of G protein signaling (RGS) protein that contains both a C2 and an RGS domain, and that binds EGL-30 via both domains, similar in organization to mammalian PDZ-RGS3; the RGS domain has GTPase activator protein (GAP) activity in vitro on mammalian G[alphai]3; RGS-7 thus may stably bind EGL-30 at all stages of EGL-30's GTPase cycle, might organize EGL-30 into a stable multiprotein signalling complex (with GTP[gamma]S), and might persistently inhibit EGL-30 when triggered by calcium or phospholipids; rgs-7 has no obvious function in mass RNAi assays
Disease_infoPotential_modelDOID:10825Homo sapiensInferred_automaticallyInferred by orthology to human genes with OMIM annotation (OMIM:145500,ENSG00000143248)
Molecular_infoCorresponding_CDSF56B6.2a
F56B6.2b
F56B6.2c
F56B6.2d
F56B6.2e
F56B6.2f
F56B6.2g
Corresponding_transcriptF56B6.2a
F56B6.2d
F56B6.2b
F56B6.2c.1
F56B6.2c.2
F56B6.2e.1
F56B6.2e.2
F56B6.2f
F56B6.2g
Other_sequence (21)
Associated_feature (18)
Experimental_infoRNAi_resultWBRNAi00048645Inferred_automaticallyRNAi_primary
WBRNAi00048644Inferred_automaticallyRNAi_primary
WBRNAi00032932Inferred_automaticallyRNAi_primary
WBRNAi00015785Inferred_automaticallyRNAi_primary
Expr_patternExpr3108
Expr1025711
Expr1032168
Expr1152407
Expr1200208
Drives_constructWBCnstr00011142
WBCnstr00035547
Construct_productWBCnstr00011142
WBCnstr00035547
Microarray_results (51)
Expression_cluster (75)
InteractionWBInteraction000523424
WBInteraction000523425
WBProcessWBbiopr:00000017
Map_infoMapXPosition-10.1117Error0.033929
PositivePositive_cloneF56B6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5042
Pseudo_map_position
Reference (14)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene