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WormBase Tree Display for Gene: WBGene00004350

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Name Class

WBGene00004350SMapS_parentSequenceF56B6
IdentityVersion2
NameCGC_namergs-7Person_evidenceWBPerson330
Sequence_nameF56B6.2
Molecular_name (27)
Other_nameCELE_F56B6.2Accession_evidenceNDBBX284606
Public_namergs-7
DB_infoDatabaseAceViewgeneXE175
WormQTLgeneWBGene00004350
WormFluxgeneWBGene00004350
NDBlocus_tagCELE_F56B6.2
PanthergeneCAEEL|WormBase=WBGene00004350|UniProtKB=Q8WQC0
familyPTHR10845
NCBIgene180645
RefSeqproteinNM_001129682.5
NM_001373262.3
NM_001373261.4
NM_001374994.1
NM_001029543.5
NM_001129681.4
NM_001373260.4
NM_001029544.6
NM_076209.7
SwissProtUniProtAccQ8WQC0
TrEMBLUniProtAccA0A4V0IJG9
Q1W0R0
H2KYQ7
A0A4V0IKM4
A0A4V0ILX5
H2KYQ8
UniProt_GCRPUniProtAccQ8WQC0
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:35WBPerson1971EventImportedInitial conversion from geneace
203 Dec 2004 16:13:27WBPerson2970EventAcquires_mergeWBGene00018936
Acquires_mergeWBGene00018936
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classrgs
Allele (194)
StrainWBStrain00026370
WBStrain00026372
WBStrain00032622
WBStrain00034758
RNASeq_FPKM (74)
GO_annotation00021823
00021824
00021825
00085200
00085201
Ortholog (38)
Paralog (12)
Structured_descriptionConcise_descriptionrgs-7 encodes three isoforms of an atypical regulator of G protein signaling (RGS) protein that contains both a C2 and an RGS domain, and that binds EGL-30 via both domains, similar in organization to mammalian PDZ-RGS3; the RGS domain has GTPase activator protein (GAP) activity in vitro on mammalian G[alphai]3; RGS-7 thus may stably bind EGL-30 at all stages of EGL-30's GTPase cycle, might organize EGL-30 into a stable multiprotein signalling complex (with GTP[gamma]S), and might persistently inhibit EGL-30 when triggered by calcium or phospholipids; rgs-7 has no obvious function in mass RNAi assaysPaper_evidenceWBPaper00005654
WBPaper00005958
WBPaper00013066
Curator_confirmedWBPerson567
Date_last_updated18 Jun 2007 00:00:00
Automated_descriptionEnables GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Located in cell cortex. Is an ortholog of several human genes including RGS1 (regulator of G protein signaling 1); RGS13 (regulator of G protein signaling 13); and RGS4 (regulator of G protein signaling 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF56B6.2a
F56B6.2b
F56B6.2c
F56B6.2e
F56B6.2f
F56B6.2g
F56B6.2h
F56B6.2i
F56B6.2j
Corresponding_CDS_historyF56B6.2d:wp271
Corresponding_transcriptF56B6.2a.1
F56B6.2b.1
F56B6.2c.1
F56B6.2e.1
F56B6.2f.1
F56B6.2g.1
F56B6.2h.1
F56B6.2i.1
F56B6.2j.1
Other_sequence (21)
Associated_feature (27)
Experimental_infoRNAi_resultWBRNAi00048645Inferred_automaticallyRNAi_primary
WBRNAi00048644Inferred_automaticallyRNAi_primary
WBRNAi00032932Inferred_automaticallyRNAi_primary
WBRNAi00015785Inferred_automaticallyRNAi_primary
Expr_patternExpr3108
Expr1025711
Expr1032168
Expr1152407
Expr1200208
Expr2015330
Expr2033564
Drives_constructWBCnstr00011142
WBCnstr00035547
Construct_productWBCnstr00011142
WBCnstr00035547
Microarray_results (53)
Expression_clusterWBPaper00028788:MPK-1_Response_Medium
WBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00035211:age-1_vs_N2_downregulated
WBPaper00037682:sma-2_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_larva_enriched
WBPaper00037950:PVD-OLL-neurons_larva_SelectivelyEnriched
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00044736:flat_dev_expression
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Oogenic
WBPaper00045729:gld-2(RNAi)_downregulated
WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00045974:NSM_enriched_totalRNA_tiling
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049905:Age_variant_expression
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053289:DREAM-target
WBPaper00053302:alovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053388:dauer_regulated_Cluster1
WBPaper00053599:female_vs_male_upregulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055386:daf-2(e1370)_downregulated
WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056161:hermaphrodite_enriched_siRNA
WBPaper00056218:daf-16(mu86)_upregulated_Day7
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00059754:C.neoformans_H99_upregulated
WBPaper00059763:neuron_expressed
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060278:atp-2(RNAi)_upregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061007:HB101_downregulated
WBPaper00061340:ABarpaaa_lineage
WBPaper00061340:ASK
WBPaper00061340:CEPsh
WBPaper00061340:RIA
WBPaper00061527:nrde-3-tra-4_10484
WBPaper00061527:R07E4.5-skp-1_1608
WBPaper00061527:utx-1_2886-swan-1_2192
WBPaper00061651:ASK_enriched
WBPaper00061651:I1_enriched
WBPaper00061651:NSM_enriched
WBPaper00061651:OLL_enriched
WBPaper00061651:PHB_enriched
WBPaper00061651:RIA_enriched
WBPaper00061651:RMD_DV_enriched
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062590:Aging_upregulated_body-wall-muscle
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064716:paraquat_upregulated
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065841:40_0
WBPaper00065841:52_0
WBPaper00065841:53_0
WBPaper00065841:63_0
WBPaper00065841:83_0
WBPaper00065841:116_0
WBPaper00065975:P-body_vs_oocyte_enriched
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066110:Doxorubicin_downregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_downregulated
cgc4489_group_5
WBPaper00025032:cluster_13
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00034661:AgNPs_downregulated
WBPaper00035588:alg-1(-)_upregulated
WBPaper00037695:CC_3-day
WBPaper00038172:tax-6null_up_regulated
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00040858:eQTL_regulated_old
WBPaper00040963:Q50_down
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00040985:AIN-2_L4_intestine
WBPaper00041267:SpaceFlight_Downregulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-exposed_24h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
WBPaper00042236:flcn-1(ok975)_upregulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00045263:ProLongevity-mtROS_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00051448:P.aeruginosa_Slow-Killing_upregulated
WBPaper00055899:nitroguanidine_regulated
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5376]:let-60(G12V)-regulated_genes
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(23_min)
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:Cluster_E
Interaction (11)
WBProcessWBbiopr:00000017
Map_infoMapXPosition-10.1117Error0.033929
PositivePositive_cloneF56B6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5042
Pseudo_map_position
Reference (17)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene