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WormBase Tree Display for Gene: WBGene00004350

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Name Class

WBGene00004350SMapS_parentSequenceF56B6
IdentityVersion2
NameCGC_namergs-7Person_evidenceWBPerson330
Sequence_nameF56B6.2
Molecular_name (27)
Other_nameCELE_F56B6.2Accession_evidenceNDBBX284606
Public_namergs-7
DB_infoDatabaseAceViewgeneXE175
WormQTLgeneWBGene00004350
WormFluxgeneWBGene00004350
NDBlocus_tagCELE_F56B6.2
PanthergeneCAEEL|WormBase=WBGene00004350|UniProtKB=Q8WQC0
familyPTHR10845
NCBIgene180645
RefSeqproteinNM_001129682.5
NM_001373262.3
NM_001373261.4
NM_001374994.1
NM_001029543.5
NM_001129681.4
NM_001373260.4
NM_001029544.6
NM_076209.7
SwissProtUniProtAccQ8WQC0
TrEMBLUniProtAccA0A4V0IJG9
Q1W0R0
H2KYQ7
A0A4V0IKM4
A0A4V0ILX5
H2KYQ8
UniProt_GCRPUniProtAccQ8WQC0
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:35WBPerson1971EventImportedInitial conversion from geneace
203 Dec 2004 16:13:27WBPerson2970EventAcquires_mergeWBGene00018936
Acquires_mergeWBGene00018936
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classrgs
Allele (194)
StrainWBStrain00026370
WBStrain00026372
WBStrain00032622
WBStrain00034758
RNASeq_FPKM (74)
GO_annotation00021630
00021631
00021632
00084878
00084879
Ortholog (38)
Paralog (12)
Structured_descriptionConcise_descriptionrgs-7 encodes three isoforms of an atypical regulator of G protein signaling (RGS) protein that contains both a C2 and an RGS domain, and that binds EGL-30 via both domains, similar in organization to mammalian PDZ-RGS3; the RGS domain has GTPase activator protein (GAP) activity in vitro on mammalian G[alphai]3; RGS-7 thus may stably bind EGL-30 at all stages of EGL-30's GTPase cycle, might organize EGL-30 into a stable multiprotein signalling complex (with GTP[gamma]S), and might persistently inhibit EGL-30 when triggered by calcium or phospholipids; rgs-7 has no obvious function in mass RNAi assaysPaper_evidenceWBPaper00005654
WBPaper00005958
WBPaper00013066
Curator_confirmedWBPerson567
Date_last_updated18 Jun 2007 00:00:00
Automated_descriptionEnables GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Located in cell cortex. Is an ortholog of several human genes including RGS1 (regulator of G protein signaling 1); RGS13 (regulator of G protein signaling 13); and RGS4 (regulator of G protein signaling 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Molecular_infoCorresponding_CDSF56B6.2a
F56B6.2b
F56B6.2c
F56B6.2e
F56B6.2f
F56B6.2g
F56B6.2h
F56B6.2i
F56B6.2j
Corresponding_CDS_historyF56B6.2d:wp271
Corresponding_transcriptF56B6.2a.1
F56B6.2b.1
F56B6.2c.1
F56B6.2e.1
F56B6.2f.1
F56B6.2g.1
F56B6.2h.1
F56B6.2i.1
F56B6.2j.1
Other_sequence (21)
Associated_feature (27)
Experimental_infoRNAi_resultWBRNAi00048645Inferred_automaticallyRNAi_primary
WBRNAi00048644Inferred_automaticallyRNAi_primary
WBRNAi00032932Inferred_automaticallyRNAi_primary
WBRNAi00015785Inferred_automaticallyRNAi_primary
Expr_patternExpr3108
Expr1025711
Expr1032168
Expr1152407
Expr1200208
Expr2015330
Expr2033564
Drives_constructWBCnstr00011142
WBCnstr00035547
Construct_product (2)
Microarray_results (53)
Expression_cluster (135)
Interaction (11)
WBProcessWBbiopr:00000017
Map_infoMapXPosition-10.1117Error0.033929
PositivePositive_cloneF56B6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5042
Pseudo_map_position
Reference (17)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene