WormBase Tree Display for Gene: WBGene00006742
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| WBGene00006742 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-2 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T02C5.5 | ||||||||
| Molecular_name (45) | |||||||||
| Other_name | CELE_T02C5.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | unc-2 | ||||||||
| DB_info | Database | AceView | gene | XD330 | |||||
| WormQTL | gene | WBGene00006742 | |||||||
| WormFlux | gene | WBGene00006742 | |||||||
| OMIM | disease | 141500 | |||||||
| gene | 601011 | ||||||||
| 601013 | |||||||||
| NDB | locus_tag | CELE_T02C5.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006742|UniProtKB=A0A3B1E663 | |||||||
| family | PTHR45628 | ||||||||
| NCBI | gene | 180570 | |||||||
| RefSeq | protein (15) | ||||||||
| TrEMBL | UniProtAcc (15) | ||||||||
| UniProt_GCRP | UniProtAcc | A0A3B1E663 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (11) | |||||||||
| Disease_info | Experimental_model | DOID:6364 | Homo sapiens | Paper_evidence | WBPaper00006272 | ||||
| Accession_evidence | OMIM | 141500 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 14 Apr 2014 00:00:00 | ||||||||
| Potential_model | DOID:10024 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | |||||
| DOID:0080454 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | ||||||
| DOID:0050956 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | ||||||
| DOID:0112205 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1392) | ||||||
| DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1389) | ||||||
| DOID:0111181 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | ||||||
| DOID:0050214 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1389) | ||||||
| DOID:0050990 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | ||||||
| DOID:4724 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1389) | ||||||
| DOID:6364 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | ||||||
| Disease_relevance | Mutations in the human calcium channel CACNA1A (Calcium channel, voltage-dependent, P/Q type, alpha-1A subunit) are associated with Episodic ataxia (type 2), which affects the nervous system, resulting in migraines, vision and speech defects, and muscle weakness; mutations in CACNA1A also cause Spinocerebellar ataxia (type 6), a progressive movement disorder; voltage dependent calcium channels mediate calcium entry into cells and are involved in several calcium dependent processes; genetic studies in elegans show that unc-2, the ortholog of CACNA1A, negatively modulates a transforming growth factor (TGF)-beta pathway to affect certain phenotypes like movement, and for the normal accumulation of serotonin levels; further, unc-2 dependent inhibition of the TGF-beta pathway regulates the transcriptional expression of trytophan hydroxylase (tph-1) in serotonergic neurons under stress conditions like starvation and raised temperature; a construct expressing human CACNA1A can substitute for unc-2 function in elegans. | Homo sapiens | Paper_evidence | WBPaper00006272 | |||||
| Accession_evidence | OMIM | 601011 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 14 Apr 2014 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000025 | ||||||||
| Molecular_info | Corresponding_CDS (15) | ||||||||
| Corresponding_CDS_history | T02C5.5b:wp102 | ||||||||
| T02C5.5d:wp271 | |||||||||
| T02C5.5e:wp272 | |||||||||
| Corresponding_transcript (15) | |||||||||
| Other_sequence (50) | |||||||||
| Associated_feature (42) | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00003100 | ||||||||
| WBCnstr00003101 | |||||||||
| WBCnstr00004845 | |||||||||
| WBCnstr00004847 | |||||||||
| WBCnstr00038221 | |||||||||
| Construct_product | WBCnstr00005852 | ||||||||
| WBCnstr00005853 | |||||||||
| WBCnstr00005854 | |||||||||
| WBCnstr00020432 | |||||||||
| WBCnstr00022471 | |||||||||
| WBCnstr00023025 | |||||||||
| WBCnstr00023027 | |||||||||
| Microarray_results (47) | |||||||||
| Expression_cluster (201) | |||||||||
| Interaction (139) | |||||||||
| Anatomy_function | WBbtf0544 | ||||||||
| WBbtf0547 | |||||||||
| WBbtf0550 | |||||||||
| Map_info | Map | X | Position | -13.7946 | Error | 0.063386 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | T02C5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 145 | |||||||
| 153 | |||||||||
| 154 | |||||||||
| 155 | |||||||||
| 156 | |||||||||
| 157 | |||||||||
| 3151 | |||||||||
| 4456 | |||||||||
| 4457 | |||||||||
| 7099 | |||||||||
| Multi_point (28) | |||||||||
| Pos_neg_data (23) | |||||||||
| Landmark_gene | |||||||||
| Reference (201) | |||||||||
| Method | Gene |
