WormBase Tree Display for Gene: WBGene00006745
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| WBGene00006745 | SMap | S_parent | Sequence | B0273 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-5 | Person_evidence | WBPerson261 | |||||
| Sequence_name | B0273.4 | ||||||||
| Molecular_name (19) | |||||||||
| Other_name | CELE_B0273.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | unc-5 | ||||||||
| DB_info | Database | AceView | gene | 4G260 | |||||
| WormQTL | gene | WBGene00006745 | |||||||
| WormFlux | gene | WBGene00006745 | |||||||
| NDB | locus_tag | CELE_B0273.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006745|UniProtKB=Q26261 | |||||||
| family | PTHR12582 | ||||||||
| NCBI | gene | 177334 | |||||||
| RefSeq | protein | NM_001392311.1 | |||||||
| NM_068422.6 | |||||||||
| NM_001306822.3 | |||||||||
| NM_068421.6 | |||||||||
| NM_001306820.3 | |||||||||
| NM_001380233.1 | |||||||||
| SwissProt | UniProtAcc | Q26261 | |||||||
| TREEFAM | TREEFAM_ID | TF316767 | |||||||
| UniProt_GCRP | UniProtAcc | Q26261 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00142936 | ||||||||
| Allele (350) | |||||||||
| Legacy_information | e53 : severe coiler grows well; L1 also severe coiler; dorsal hypodermal cells abnormal dorsal nerve cord absent or almost absent cord commissures fail to reach targets muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; Egl-c. ES3 ME0. NA7 (e553 (resemble e53) e152 (weaker phenotype behaviorally and anatomically dorsal cord partially formed) etc.). | ||||||||
| See also e2349, e2355, e2387 | |||||||||
| [C.elegansII] e53 : severe coiler, grows well; L1 also severe coiler; dorsal hypodermal cells abnormal, dorsal nerve cord absent or almost absent, cord commissures fail to reach targets; muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; abnormal gonad arms;Egl-c. ES3 ME0. OA>10: e553 (resembles e53), e152 (weaker phenotype behaviorally and anatomically, dorsal cord partially formed), bx8, ev447,st1001tci, etc. See also unc-6, unc-40. Cloned: 3.0 and 3.1 kb transcripts (different 5') ,encode predicted 919 aa transmembrane protein,2 Ig domains and 2 TSP domains. Mosaic analysis indicates autonomous action in neurons, DTC; ectopic expression in touch cells can cause their dorsalward migration. [Hedgecock et al. 1990; Leung-Hagesteijn et al. 1992; Hamelin et al. 1993; NW] | |||||||||
| Strain (67) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (53) | |||||||||
| Ortholog (53) | |||||||||
| Structured_description | Concise_description | unc-5 encodes a netrin receptor; unc-5 activity is required cell autonomously for dorsalward cell and pioneer motor axon migrations along the body wall that are essential for normal locomotion and gonad development; unc-5 mRNAs are expressed throughout the entire life cycle, with increasing levels seen as animals progess to adulthood. | Paper_evidence | WBPaper00001619 | |||||
| WBPaper00005582 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 25 Jan 2006 00:00:00 | ||||||||
| Automated_description | Enables netrin receptor activity and protein tyrosine kinase binding activity. Involved in several processes, including axon guidance; regulation of neuron projection development; and sex differentiation. Acts upstream of or within distal tip cell migration. Located in axonal growth cone. Expressed in several structures, including distal tip cell; excretory canal; head neurons; motor neurons; and somatic nervous system. Is an ortholog of human UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | B0273.4a | |||||||
| B0273.4b | |||||||||
| B0273.4c | |||||||||
| B0273.4d | |||||||||
| B0273.4e | |||||||||
| B0273.4f | |||||||||
| Corresponding_CDS_history | B0273.4b:wp134 | ||||||||
| Corresponding_transcript | B0273.4a.1 | ||||||||
| B0273.4b.1 | |||||||||
| B0273.4c.1 | |||||||||
| B0273.4d.1 | |||||||||
| B0273.4d.2 | |||||||||
| B0273.4e.1 | |||||||||
| B0273.4f.1 | |||||||||
| Other_sequence | JI475712.1 | ||||||||
| JI459463.1 | |||||||||
| CR01727 | |||||||||
| CRC00510_2 | |||||||||
| CRC06468_1 | |||||||||
| CR03346 | |||||||||
| CJC11776_1 | |||||||||
| JI165198.1 | |||||||||
| Dviv_isotig23366 | |||||||||
| Associated_feature (24) | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct (17) | |||||||||
| Construct_product (13) | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (154) | |||||||||
| Interaction (206) | |||||||||
| WBProcess | WBbiopr:00000025 | ||||||||
| Map_info | Map | IV | Position | 1.78303 | Error | 0.002438 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | B0273 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| C37G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Outside_rearr | nDp5 | |||||||
| Mapping_data | 2_point (21) | ||||||||
| Multi_point (96) | |||||||||
| Pos_neg_data | 3700 | ||||||||
| 9031 | |||||||||
| 9036 | |||||||||
| 10892 | |||||||||
| Landmark_gene | |||||||||
| Reference (341) | |||||||||
| Remark | [Culotti J] The unc-5 expression pattern is now published in Su et al., Development 127,585-594 (2000) | ||||||||
| Method | Gene |
