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WormBase Tree Display for Gene: WBGene00006762

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Name Class

WBGene00006762SMapS_parentSequenceY37D8A
IdentityVersion1
NameCGC_nameunc-25Person_evidenceWBPerson261
Sequence_nameY37D8A.23
Molecular_nameY37D8A.23a
Y37D8A.23a.1
CE20226
Y37D8A.23b
CE31832
Y37D8A.23c
CE32012
Y37D8A.23b.1
Y37D8A.23c.1
Other_nameCELE_Y37D8A.23Accession_evidenceNDBBX284603
Public_nameunc-25
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_info (12)
Disease_infoExperimental_modelDOID:1574Homo sapiensPaper_evidenceWBPaper00045914
Curator_confirmedWBPerson324
Date_last_updated06 Jun 2019 00:00:00
DOID:1826Homo sapiensPaper_evidenceWBPaper00035198
Curator_confirmedWBPerson38202
Date_last_updated04 Jun 2018 00:00:00
DOID:0050669Homo sapiensPaper_evidenceWBPaper00024523
Accession_evidenceOMIM603513
Curator_confirmedWBPerson324
Date_last_updated22 Apr 2013 00:00:00
Potential_model (12)
Disease_relevanceMutations in Glutamic acid decarboxylase (GAD1), the human ortholog of elegans unc-25, are associated with autosomal recessive spastic cerebral palsy, a movement disorder caused by abnormalities in the brain; studies in elegans show that unc-25 is required for gamma-amino-butyric acid (GABA) synthesis and GABA-mediated behavioral functions; various GABA mutants in elegans, like unc-25, the GABA vesicular transporters (unc-46 and unc-47), and the GABA-A receptor, unc-49, all present head-bobbing convulsions.Homo sapiensPaper_evidenceWBPaper00024523
WBPaper00042136
Accession_evidenceOMIM603513
605363
Curator_confirmedWBPerson324
Date_last_updated22 Apr 2013 00:00:00
Models_disease_in_annotationWBDOannot00000163
Models_disease_assertedWBDOannot00000549
WBDOannot00000702
WBDOannot00000703
Molecular_infoCorresponding_CDSY37D8A.23a
Y37D8A.23b
Y37D8A.23c
Corresponding_transcriptY37D8A.23a.1
Y37D8A.23b.1
Y37D8A.23c.1
Other_sequence (65)
Associated_featureWBsf645681
WBsf994764
WBsf994765
WBsf1016280
WBsf1016281
WBsf1016282
WBsf225951
WBsf225952
Experimental_infoRNAi_resultWBRNAi00090105Inferred_automaticallyRNAi_primary
WBRNAi00077589Inferred_automaticallyRNAi_primary
WBRNAi00077586Inferred_automaticallyRNAi_primary
WBRNAi00027872Inferred_automaticallyRNAi_primary
WBRNAi00089945Inferred_automaticallyRNAi_primary
WBRNAi00002293Inferred_automaticallyRNAi_primary
WBRNAi00055883Inferred_automaticallyRNAi_primary
WBRNAi00090263Inferred_automaticallyRNAi_primary
WBRNAi00089782Inferred_automaticallyRNAi_primary
Expr_pattern (15)
Drives_construct (136)
Construct_productWBCnstr00010179
WBCnstr00038179
WBCnstr00038181
Regulate_expr_clusterWBPaper00065734:unc-25(e156)_downregulated
WBPaper00065734:unc-25(e156)_upregulated
Microarray_results (30)
Expression_cluster (186)
Interaction (55)
WBProcessWBbiopr:00000010
Map_infoMapIIIPosition20.6616Error0.04207
Well_ordered
PositivePositive_cloneY37D8AInferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point57
68
78
6019
6109
7009
7010
Multi_point (42)
Pos_neg_data354
8378
8386
8389
8550
Reference (216)
MethodGene