Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006775

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006775SMapS_parentSequenceF56A12
IdentityVersion2
NameCGC_nameunc-39Person_evidenceWBPerson261
Sequence_nameF56A12.1
Molecular_nameF56A12.1
F56A12.1.1
CE37921
Other_namemig-3
ceh-35Paper_evidenceWBPaper00024327
CELE_F56A12.1Accession_evidenceNDBBX284605
Public_nameunc-39
DB_infoDatabaseAceViewgene5O855
WormQTLgeneWBGene00006775
WormFluxgeneWBGene00006775
OMIMdisease610896
160900
gene600963
NDBlocus_tagCELE_F56A12.1
PanthergeneCAEEL|WormBase=WBGene00006775|UniProtKB=O17894
familyPTHR10390
NCBIgene191623
RefSeqproteinNM_074162.3
SwissProtUniProtAccO17894
UniProt_GCRPUniProtAccO17894
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
209 Nov 2004 14:53:34WBPerson2970EventAcquires_mergeWBGene00000456
Acquires_mergeWBGene00000456
StatusLive
Gene_info (11)
Disease_infoExperimental_modelDOID:11722Homo sapiensPaper_evidenceWBPaper00024327
Accession_evidenceOMIM160900
Curator_confirmedWBPerson324
Date_last_updated24 Oct 2013 00:00:00
DOID:14702Homo sapiensPaper_evidenceWBPaper00024327
Accession_evidenceOMIM610896
Curator_confirmedWBPerson324
Date_last_updated24 Oct 2013 00:00:00
Potential_modelDOID:0111424Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10891)
Disease_relevanceMutations in the human Six5 protein have been implicated in Myotonic dystrophy 1 (DM1), a highly variable disease characterized by progressive muscle wasting, eye cataracts, cardiac abnormalities, and insulin resistance; in C. elegans, mutants in unc-29 (e257), orthologous to human Six5, show uncoordinated movement, mesodermal defects, and neuronal developmental and pathfinding defects; these studies indicate that unc-29/Six5 may be involved in development of mesoderm and differentiation and migration of neurons; the variable expressivity and penetrance of unc-39 defects are reminiscent of the pleiotropy seen in DM1 patients; some of the unc-29 mutant defects (coelomocyte specification) could be rescued by a transgene containing Six domain and homeodomain coding region from human Six5, showing a functional conservation between unc-29 and Six5; these studies indicate that unc-29 serves as a model to study how Six5 plays a role in conditions leading to myotonic dystrophy.Homo sapiensPaper_evidenceWBPaper00024327
Accession_evidenceOMIM600963
160900
610896
Curator_confirmedWBPerson324
Date_last_updated01 May 2014 00:00:00
Models_disease_assertedWBDOannot00000238
WBDOannot00000299
Molecular_infoCorresponding_CDSF56A12.1
Corresponding_CDS_historyF56A12.1:wp137
Corresponding_transcriptF56A12.1.1
Other_sequenceAcan_isotig06578
Dviv_isotig15575
Dviv_isotig15576
Acan_isotig06577
Oden_isotig18067
Tcir_isotig25512
Oden_isotig25907
JI463737.1
Oden_isotig18066
JI211494.1
Associated_featureWBsf647528
WBsf662081
WBsf662082
WBsf662083
WBsf978863
WBsf1001995
WBsf1020832
WBsf232919
WBsf232920
Gene_product_binds (218)
Transcription_factorWBTranscriptionFactor000219
Experimental_infoRNAi_resultWBRNAi00101784Inferred_automaticallyRNAi_primary
WBRNAi00032912Inferred_automaticallyRNAi_primary
WBRNAi00089718Inferred_automaticallyRNAi_primary
WBRNAi00090158Inferred_automaticallyRNAi_primary
WBRNAi00090317Inferred_automaticallyRNAi_primary
WBRNAi00061182Inferred_automaticallyRNAi_primary
WBRNAi00015762Inferred_automaticallyRNAi_primary
WBRNAi00048581Inferred_automaticallyRNAi_primary
WBRNAi00114716Inferred_automaticallyRNAi_primary
WBRNAi00089999Inferred_automaticallyRNAi_primary
Expr_pattern (12)
Drives_constructWBCnstr00004349
WBCnstr00011130
WBCnstr00012730
WBCnstr00015880
WBCnstr00016522
WBCnstr00034159
Construct_productWBCnstr00011130
WBCnstr00015880
WBCnstr00016701
WBCnstr00034159
Regulate_expr_clusterWBPaper00050496:unc-39(hp701)_regulated
Microarray_results (20)
Expression_cluster (143)
Interaction (134)
Map_infoMapVPosition6.28117Error0.001023
PositivePositive_cloneF56A12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point132
839
1725
Multi_point (14)
Pos_neg_data297
2131
3132
4308
Reference (35)
MethodGene