WormBase Tree Display for Gene: WBGene00006797
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| WBGene00006797 | SMap | S_parent | Sequence | Y110A7A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-63 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y110A7A.3 | ||||||||
| Molecular_name | Y110A7A.3 | ||||||||
| Y110A7A.3.1 | |||||||||
| CE30706 | |||||||||
| Other_name | lev-7 | ||||||||
| tmr-3 | |||||||||
| CELE_Y110A7A.3 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | unc-63 | ||||||||
| DB_info | Database | AceView | gene | 1F717 | |||||
| WormQTL | gene | WBGene00006797 | |||||||
| WormFlux | gene | WBGene00006797 | |||||||
| NDB | locus_tag | CELE_Y110A7A.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006797|UniProtKB=Q9N587 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 172150 | |||||||
| RefSeq | protein | NM_059132.5 | |||||||
| SwissProt | UniProtAcc | Q9N587 | |||||||
| UniProt_GCRP | UniProtAcc | Q9N587 | |||||||
| OMIM | gene | 100690 | |||||||
| 100710 | |||||||||
| 100720 | |||||||||
| 100725 | |||||||||
| 100730 | |||||||||
| 118502 | |||||||||
| 118503 | |||||||||
| 118504 | |||||||||
| 118507 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Allele (119) | |||||||||
| Legacy_information | e384 : weak kinker thin inactive resistant to 1 mM levamisole sensitive to hypoosmotic shock. ES3 ME2. NA > 50 (x18 etc. : most alleles resemble e384). Also rare exceptional alleles x26 (almost normal movement slight levamisole resistance); b404 (resistant to cholinesterase inhibitor trichlorforn slightly uncoordinated slight levamisole resistance); x33 (more resistant in body than in head). | ||||||||
| See also e214, e215, e384 | |||||||||
| [C.elegansII] e214 : weak kinker, slow, inactive, resistant to 1 mM levamisole, sensitive to hypoosmotic shock; elevated acetylcholine levels. ES3 ME2. OA>50: x13 (pka lev-7, Lev,Ric, poor backing; ES3 ME3), x18, x37 etc. (most alleles resemble e214). Also rare exceptional alleles: x26 (almost normal movement, slight levamisole resistance), b404 (Ric, trichlorfon resistant, slight Lev, slight Unc), x33 (more resistant in body than in head). Previous reference allele "e384" is double with unc-11. [Lewis et al. 1980; Nguyen et al. 1995; AL; RM; TN; ZZ] | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (42) | |||||||||
| Ortholog (59) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | unc-63 encodes an alpha subunit of a levamisole-sensitive nicotinic acetylcholine receptor (L-nAChR); UNC-63 is required for normal locomotion and regulation of egg-laying behavior, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-29 and LEV-1, non-alpha L-nAChR subunits, the resulting multimer can form levamisole-gated channels; UNC-63 is expressed in body wall muscles, vulval muscles, and a large number of ventral cord neurons; UNC-63 is a member of the UNC-38-like group of nAChR subunits. | Paper_evidence | WBPaper00000031 | |||||
| WBPaper00004660 | |||||||||
| WBPaper00005223 | |||||||||
| WBPaper00005594 | |||||||||
| WBPaper00024530 | |||||||||
| WBPaper00037697 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Dec 2011 00:00:00 | ||||||||
| Automated_description | Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; cholinergic synaptic transmission; and regulation of multicellular organismal process. Located in neuromuscular junction and postsynaptic membrane. Expressed in ganglia; head muscle; motor neurons; non-striated muscle; and ventral nerve cord. Used to study alcohol use disorder and congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and lung disease (multiple). Is an ortholog of human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045914 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jun 2019 00:00:00 | ||||||||
| DOID:3635 | Homo sapiens | Paper_evidence | WBPaper00037697 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 23 Feb 2021 00:00:00 | ||||||||
| Potential_model (29) | |||||||||
| Models_disease_asserted | WBDOannot00000705 | ||||||||
| WBDOannot00000706 | |||||||||
| WBDOannot00000869 | |||||||||
| WBDOannot00000870 | |||||||||
| WBDOannot00000871 | |||||||||
| WBDOannot00000872 | |||||||||
| WBDOannot00000873 | |||||||||
| WBDOannot00000874 | |||||||||
| WBDOannot00000875 | |||||||||
| Molecular_info | Corresponding_CDS | Y110A7A.3 | |||||||
| Corresponding_transcript | Y110A7A.3.1 | ||||||||
| Other_sequence (49) | |||||||||
| Associated_feature | WBsf983609 | ||||||||
| WBsf983610 | |||||||||
| WBsf983611 | |||||||||
| WBsf983612 | |||||||||
| WBsf1009773 | |||||||||
| WBsf1009774 | |||||||||
| WBsf1009775 | |||||||||
| WBsf217630 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00004530 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00066522 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089742 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066395 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090027 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090345 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055324 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090186 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036556 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram2008 | ||||||||
| Expr3394 | |||||||||
| Expr3926 | |||||||||
| Expr6882 | |||||||||
| Expr10821 | |||||||||
| Expr1018874 | |||||||||
| Expr1032867 | |||||||||
| Expr1158864 | |||||||||
| Expr2017896 | |||||||||
| Expr2036032 | |||||||||
| Drives_construct | WBCnstr00000877 | ||||||||
| WBCnstr00003643 | |||||||||
| WBCnstr00006476 | |||||||||
| WBCnstr00006477 | |||||||||
| WBCnstr00008276 | |||||||||
| WBCnstr00009871 | |||||||||
| WBCnstr00011375 | |||||||||
| WBCnstr00011753 | |||||||||
| WBCnstr00017749 | |||||||||
| Construct_product (12) | |||||||||
| Antibody | WBAntibody00001429 | ||||||||
| WBAntibody00002210 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (112) | |||||||||
| Interaction | WBInteraction000164160 | ||||||||
| WBInteraction000503664 | |||||||||
| WBInteraction000518472 | |||||||||
| WBInteraction000518495 | |||||||||
| WBInteraction000536782 | |||||||||
| WBInteraction000540194 | |||||||||
| WBInteraction000541906 | |||||||||
| WBInteraction000541922 | |||||||||
| WBInteraction000543440 | |||||||||
| Map_info | Map | I | Position | -0.35206 | |||||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y72E2 | |||||||
| Y110A7A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 9 | |||||||
| 209 | |||||||||
| 210 | |||||||||
| 245 | |||||||||
| 246 | |||||||||
| 410 | |||||||||
| 614 | |||||||||
| 2501 | |||||||||
| Multi_point (11) | |||||||||
| Pos_neg_data (16) | |||||||||
| Reference (119) | |||||||||
| Remark | Sequence connection from [Culetto E, Sattelle DB] (via JAH) | ||||||||
| [140923 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. | |||||||||
| Method | Gene |
