WormBase Tree Display for Gene: WBGene00006802
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| WBGene00006802 | SMap | S_parent | Sequence | T07A5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-69 | Paper_evidence | WBPaper00027646 | |||||
| Person_evidence | WBPerson261 | ||||||||
| Sequence_name | T07A5.6 | ||||||||
| Molecular_name | T07A5.6a | ||||||||
| T07A5.6a.1 | |||||||||
| CE23955 | |||||||||
| T07A5.6b | |||||||||
| CE38102 | |||||||||
| T07A5.6c | |||||||||
| CE41450 | |||||||||
| T07A5.6b.1 | |||||||||
| T07A5.6c.1 | |||||||||
| Other_name | CELE_T07A5.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | unc-69 | ||||||||
| DB_info | Database | AceView | gene | 3L409 | |||||
| WormFlux | gene | WBGene00006802 | |||||||
| NDB | locus_tag | CELE_T07A5.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006802|UniProtKB=A7LPF8 | |||||||
| family | PTHR21614 | ||||||||
| NCBI | gene | 176444 | |||||||
| RefSeq | protein | NM_001027582.4 | |||||||
| NM_001027581.5 | |||||||||
| NM_001129245.5 | |||||||||
| TREEFAM | TREEFAM_ID | TF323340 | |||||||
| TrEMBL | UniProtAcc | A7LPF8 | |||||||
| Q9U377 | |||||||||
| G5EDQ5 | |||||||||
| UniProt_GCRP | UniProtAcc | A7LPF8 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 30 Oct 2007 10:02:14 | WBPerson2970 | Event | Acquires_merge | WBGene00044098 | ||||
| Name_change | Sequence_name | T07A5.6 | |||||||
| Acquires_merge | WBGene00044098 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143321 | ||||||||
| Allele (18) | |||||||||
| Legacy_information | e587 : medium coiler inactive small; abnormalities in VD and DD commissures. ES3 ME0. NA2 (e602). | ||||||||
| [C.elegansII] e587 : medium coiler, inactive, small; abnormalities in VD and DD commissures, longitudinal axon elongation. ES3 ME0. OA1: e602. Cloned: cosmid rescue (C46D2). [Brenner 1974; NG; SQ; WS] | |||||||||
| Strain (16) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00005135 | ||||||||
| 00005136 | |||||||||
| 00005137 | |||||||||
| 00005138 | |||||||||
| 00005139 | |||||||||
| 00005140 | |||||||||
| 00005141 | |||||||||
| 00005142 | |||||||||
| 00005143 | |||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | unc-69 encodes, by alternative splicing, three isoforms of a small (102- to 176-residue) coiled-coil protein required for normal axonal extension, axonal guidance, neuronal fasciculation, and synaptic vesicle localization; UNC-69 is orthologous to human SCOCO, which can transgenically rescue the locomotion defect of strong unc-69 mutants; UNC-69 is expressed in embryos, the processes and growth cones of immature neurons, and in the cell bodies of many (perhaps all) mature neurons; UNC-69 acts cell-autonomously in at least touch neurons, and perhaps all neurons; since UNC-69 binds a 19-residue conserved coiled-coil domain of UNC-76, UNC-69 and UNC-76 colocalize to neuronal puncta, unc-69 mutants phenotypically resemble unc-76, and mutations of these genes have nonallelic noncomplementation, UNC-69 and UNC-76 are likely to function as a complex. | Paper_evidence | WBPaper00000031 | |||||
| WBPaper00001345 | |||||||||
| WBPaper00002837 | |||||||||
| WBPaper00027646 | |||||||||
| WBPaper00027651 | |||||||||
| WBPaper00031100 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 18 Oct 2007 00:00:00 | ||||||||
| Automated_description | Involved in regulation of axon extension and regulation of synapse organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Expressed in CAN; HSN; ganglia; somatic nervous system; and touch receptor neurons. Is an ortholog of human SCOC (short coiled-coil protein). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T07A5.6a | |||||||
| T07A5.6b | |||||||||
| T07A5.6c | |||||||||
| Corresponding_transcript | T07A5.6a.1 | ||||||||
| T07A5.6b.1 | |||||||||
| T07A5.6c.1 | |||||||||
| Other_sequence (59) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00035291 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00062360 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4900 | ||||||||
| Expr7838 | |||||||||
| Expr1016022 | |||||||||
| Expr1032870 | |||||||||
| Expr1156304 | |||||||||
| Expr2017899 | |||||||||
| Expr2036035 | |||||||||
| Drives_construct | WBCnstr00001400 | ||||||||
| WBCnstr00012320 | |||||||||
| WBCnstr00012950 | |||||||||
| Construct_product | WBCnstr00001400 | ||||||||
| WBCnstr00012320 | |||||||||
| WBCnstr00012950 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (123) | |||||||||
| Interaction | WBInteraction000008990 | ||||||||
| WBInteraction000522715 | |||||||||
| WBInteraction000522716 | |||||||||
| WBInteraction000547046 | |||||||||
| Map_info | Map | III | Position | 2.3102 | Error | 0.00237 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf40 | |||||||
| Positive_clone | T07A5 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | tnDf2 | |||||||
| Mapping_data | 2_point | 72 | |||||||
| 578 | |||||||||
| 702 | |||||||||
| 5137 | |||||||||
| 6121 | |||||||||
| Multi_point (75) | |||||||||
| Pos_neg_data | 362 | ||||||||
| 669 | |||||||||
| 1597 | |||||||||
| 1620 | |||||||||
| 4768 | |||||||||
| 8638 | |||||||||
| 9454 | |||||||||
| 10533 | |||||||||
| Reference (52) | |||||||||
| Remark | on same cosmid as unc-50; genetic map data indicate unc-69 left of unc-50 JAH 01/01 | ||||||||
| Method | Gene |
