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WormBase Tree Display for Gene: WBGene00006812

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Name Class

WBGene00006812SMapS_parentSequenceF25C8
IdentityVersion2
NameCGC_nameunc-80Person_evidenceWBPerson261
Sequence_nameF25C8.3
Molecular_name (15)
Other_nameCELE_F25C8.3Accession_evidenceNDBBX284605
Public_nameunc-80
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
213 Nov 2007 10:02:04WBPerson2970EventAcquires_mergeWBGene00009105
Acquires_mergeWBGene00009105
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classunc
Reference_alleleWBVar00143879
Allele (316)
Legacy_informatione1272 : slightly sluggish tends to pause good movement. ES1 ME3. NA2 (e1069).
See also e1069, e1272
[C.elegansII] e1272 : slightly sluggish, tends to pause ("fainter"), good movement; hypersensitive to volatile anaesthetics.ES1 ME3. OA2: e1069, m513. [Sedensky and Meneely 1987; Morgan et al. 1991; CW]
StrainWBStrain00032777
WBStrain00040621
WBStrain00004238
WBStrain00004286
RNASeq_FPKM (74)
GO_annotation (15)
Ortholog (44)
Structured_descriptionConcise_descriptionunc-80 encodes a novel protein, conserved amongst C. elegans, Drosophila, and vertebrates; unc-79 functions in a pathway with unc-77 and nca-2, which encode alpha-1 subunits of voltage-insensitive cation leak channels, to regulate presynaptic activation and thus, locomotion and the response to specific volatile anesthetics; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-80::gfp reporter fusion is expressed in many sensory and all motoneurons; in the nerve ring and in dorsal and ventral nerve cords, UNC-80 localizes to specific axonal regions, but not to synapses; UNC-80, UNC-77, and UNC-79, an additional novel protein believed to act in the same pathway, reciprocally regulate their expression levels in neurons.Paper_evidenceWBPaper00001281
WBPaper00031000
WBPaper00031592
Curator_confirmedWBPerson1843
Date_last_updated22 Jun 2010 00:00:00
Automated_descriptionEnables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Is an ortholog of human UNC80 (unc-80 homolog, NALCN channel complex subunit).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Disease_infoPotential_modelEFO:MONDO:0014176Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:26582)
Molecular_infoCorresponding_CDSF25C8.3a
F25C8.3b
F25C8.3c
F25C8.3d
F25C8.3e
Corresponding_CDS_historyF25C8.3:wp87
F25C8.3:wp109
F25C8.3a:wp182
Corresponding_transcriptF25C8.3a.1
F25C8.3b.1
F25C8.3c.1
F25C8.3d.1
F25C8.3e.1
Other_sequence (25)
Associated_featureWBsf647771
WBsf662284
WBsf662285
WBsf662286
WBsf1003660
WBsf1003661
WBsf1003662
WBsf1022024
WBsf1022025
WBsf1022026
Experimental_infoRNAi_result (12)
Expr_patternExpr4994
Expr8059
Expr8061
Expr16166
Expr1026757
Expr1032878
Expr1149400
Expr2017910
Expr2036046
Drives_constructWBCnstr00000610
WBCnstr00001622
WBCnstr00013085
WBCnstr00042790
Construct_productWBCnstr00000610
Microarray_results (26)
Expression_cluster (189)
Interaction (41)
Map_infoMapVPosition25.581Error0.021198
PositivePositive_cloneF25C8Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point1568
Reference (46)
MethodGene