WormBase Tree Display for Gene: WBGene00006822
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| WBGene00006822 | SMap | S_parent | Sequence | C46F11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-93 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C46F11.1 | ||||||||
| Molecular_name | C46F11.1a | ||||||||
| C46F11.1a.1 | |||||||||
| CE30906 | |||||||||
| C46F11.1b | |||||||||
| CE37957 | |||||||||
| C46F11.1b.1 | |||||||||
| Other_name | CELE_C46F11.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | unc-93 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00006822 | |||||
| WormFlux | gene | WBGene00006822 | |||||||
| NDB | locus_tag | CELE_C46F11.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006822|UniProtKB=Q93380 | |||||||
| family | PTHR19444 | ||||||||
| NCBI | gene | 175466 | |||||||
| RefSeq | protein | NM_001026047.5 | |||||||
| NM_001381807.1 | |||||||||
| SwissProt | UniProtAcc | Q93380 | |||||||
| TREEFAM | TREEFAM_ID | TF314905 | |||||||
| UniProt_GCRP | UniProtAcc | Q93380 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00144047 | ||||||||
| Allele (189) | |||||||||
| Legacy_information | Class 3 allele e1500sd : adults paralysed Egl; slightly long; abnormal muscle; contract and relax when prodded (`rubber-band' phenotype). ES3 ME0. Poor mating in e1500/+ males. NA (Class 3) 2 (n200 : resembles e1500 but less severe phenotype). Class 1 (loss-of-function) alleles n392 : no phenotype alone but fails to complement e1500. Intragenic revertants of e1500 all have Class 1 phenotype probably null alleles e.g. e1500n234amber. NA (Class 1) > 30. See also sup-9 sup-10 sup-11 sup-18. | ||||||||
| See also n192, n200, n201, n202, n203, n204, n205, n206, n207, n208, n209, n210, n211, n212, n214, n215, n216, n217, n218, n220, n224, n225, n226, n230, n231, n232, n234, n235, n236, n239, n243, n244, n246, n248, n254, n255, n256, n257, n259, n267, n268, n270, n291, n340, n341, n343, n344, n348, n349, n351, n352, n354, n392, n393, n394, n395, n396, n509, n511, n512, n516, n517, n520, n523, n618, n620, n623, n624, n626, n627, n629, n657, n660, n663, n665, n666, n667, n978, n979, n980, n981, n982, n1011, n1018, n1019, n1021, n1024, n1027 | |||||||||
| [Reiner D]] Mac-d (Muscle ACtivation-Defective) | |||||||||
| [C.elegansII] e1500sd : adults paralysed, Egl; slightly long;abnormal muscle; contract and relax when prodded (`rubber-band' phenotype). Muscle activation defective (flaccid, long).ES3 ME0. Poor mating in e1500/+ males. Neomorphic allele, gf. OA1 (gf): n200(resembles e1500 but less severe phenotype).Both gf alleles suppressed by sup-9, sup-10,sup-11, sup-18. Also lf alleles: n392 (no phenotype alone but fails to complement e1500), n393 etc. Intragenic revertants of e1500 all have similar WT lf phenotype: e1500n234amb, des, e1500n200spo, e1500n243gri, e1500n1415::Tc1, etc. OA>30 (ird). Cloned: 2.2 kb transcripts (slightly different 5'), encoding 700 and 705 aa predicted novel proteins with multiple (5-10) possible TM domains. [Greenwald and Horvitz 1980; Levin and Horvitz 1992;MT] | |||||||||
| Strain (31) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (39) | |||||||||
| Structured_description | Concise_description | unc-93 encodes a novel transmembrane protein that affects muscle contraction and egg laying; UNC-93 is predicted to be a component of a multi-protein complex containing the SUP-9 two-pore potassium channel and the SUP-10 transmembrane protein; an UNC-93::GFP fusion protein is expressed in body wall muscle membranes and dense bodies as well as in the vulval and intestinal muscles; neuronal UNC-93::GFP expression is found in the four SIA neurons that originate in the head, receive some synapses in the nerve ring, and extend posteriorly directed processes; in muscle cells, UNC-93::GFP colocalizes with SUP-9 to dense bodies and membranes. | Paper_evidence | WBPaper00000486 | |||||
| WBPaper00000564 | |||||||||
| WBPaper00001525 | |||||||||
| WBPaper00001800 | |||||||||
| WBPaper00006135 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 26 Jun 2008 00:00:00 | ||||||||
| Automated_description | Enables potassium channel regulator activity. Involved in regulation of muscle contraction and regulation of potassium ion transport. Located in plasma membrane and striated muscle dense body. Expressed in SIA; body wall musculature; and non-striated muscle. Is an ortholog of human UNC93A (unc-93 homolog A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C46F11.1a | |||||||
| C46F11.1b | |||||||||
| Corresponding_CDS_history | C46F11.1:wp80 | ||||||||
| C46F11.1:wp138 | |||||||||
| C46F11.1:wp140 | |||||||||
| Corresponding_transcript | C46F11.1a.1 | ||||||||
| C46F11.1b.1 | |||||||||
| Other_sequence | FE914682.1 | ||||||||
| FE913923.1 | |||||||||
| Dviv_isotig29800 | |||||||||
| ASC31488_1 | |||||||||
| JI167429.1 | |||||||||
| Associated_feature | WBsf991851 | ||||||||
| WBsf991852 | |||||||||
| WBsf991853 | |||||||||
| WBsf991854 | |||||||||
| WBsf224634 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr2773 | ||||||||
| Expr2775 | |||||||||
| Expr1019911 | |||||||||
| Expr1032886 | |||||||||
| Expr1146588 | |||||||||
| Expr2017919 | |||||||||
| Expr2036055 | |||||||||
| Drives_construct (19) | |||||||||
| Construct_product (23) | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (85) | |||||||||
| Interaction (54) | |||||||||
| Map_info | Map | III | Position | -5.0882 | Error | 0.020586 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf6 | |||||||
| nDf7 | |||||||||
| nDf8 | |||||||||
| nDf10 | |||||||||
| nDf11 | |||||||||
| nDf12 | |||||||||
| nDf13 | |||||||||
| nDf14 | |||||||||
| nDf15 | |||||||||
| Positive_clone | C46F11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| MT#JL932 | |||||||||
| Mapping_data | 2_point | 402 | |||||||
| 403 | |||||||||
| 6037 | |||||||||
| 6039 | |||||||||
| 6040 | |||||||||
| Multi_point (46) | |||||||||
| Pos_neg_data (11) | |||||||||
| Landmark_gene | |||||||||
| Reference (114) | |||||||||
| Method | Gene |
