WormBase Tree Display for Variation: WBVar00143101

WBVar00143101 Evidence: Paper_evidence: WBPaper00031010
  Name: Public_name: e306
    Other_name: CE36501:p.Trp184Ter
      T07A5.2.1:c.552G>A
    HGVSg: CHROMOSOME_III:g.10315933C>T
  Sequence_details: SMap: S_parent: Sequence: T07A5
    Flanking_sequences: acggaaagttcgtgaccaggacgtcgagtg ggttattgcttcgatgtacatctaaacgcg
    Mapping_target: T07A5
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00031010
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004144
      WBStrain00027163
      WBStrain00027198
      WBStrain00027199
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00006785
    Transcript: T07A5.2.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: T07A5.2.1:c.552G>A
        HGVSp: CE36501:p.Trp184Ter
        cDNA_position: 584
        CDS_position: 552
        Protein_position: 184
        Exon_number: 4/6
        Codon_change: tgG/tgA
        Amino_acid_change: W/*
    Interactor: WBInteraction000503020
  Isolation: Mutagen: EMS Paper_evidence: WBPaper00031010
  Genetics: Interpolated_map_position: III 2.3086
    Mapping_data: In_2_point: 56
        75
      In_multi_point (20)
      In_pos_neg_data: 650
        1619
        2722
        3243
        5726
        5734
  Description: Phenotype: WBPhenotype:0000002 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: weak kinker Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000032 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Animals are severely debilitated at 25 C. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000421 Paper_evidence: WBPaper00000484
          WBPaper00035548
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: resistant to 1 mM levamisole; extracts lack levamisole binding. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 1mM levamisole Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000519 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: extracts lack levamisole binding Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000554 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: sensitive to hypoosmotic shock Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00000031
          WBPaper00000484
          WBPaper00035548
        Curator_confirmed: WBPerson48
          WBPerson2021
          WBPerson712
        Remark: No backward motion in L1 larvae. Newly hatched larvae can barely move forward. Adults have a mild Unc defect where the mutants move forward in a slow decayed sine wave. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00000484
                Curator_confirmed: WBPerson2021
            WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00000484
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000646 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: slow but fairly active Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001852 Paper_evidence: WBPaper00035074
        Curator_confirmed: WBPerson2021
        Remark: Mutants are resistant to tribendimidine Paper_evidence: WBPaper00035074
            Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000315 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
      WBPhenotype:0000478 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Mutants tend to remain within the borders of bacterial lawns as does the wild-type. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
      WBPhenotype:0001084 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Attraction to sodium chloride is normal (See methods). Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
      WBPhenotype:0001414 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000484
          Curator_confirmed: WBPerson2021
  Reference: WBPaper00035548
    WBPaper00035074
    WBPaper00000031
    WBPaper00000484
  Method: Substitution_allele