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WormBase Tree Display for Variation: WBVar00144038

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Name Class

WBVar00144038EvidencePaper_evidenceWBPaper00026986
NamePublic_namee1489
Other_nameT07G12.12a.1:c.775G>A
CE36715:p.Gly259Arg
HGVSgCHROMOSOME_IV:g.10563247G>A
Sequence_detailsSMapS_parentSequenceT07G12
Flanking_sequencesaatcgagcaattgcgtggaagaggaaatatgaaaacttcgtcttatcgatcacgcattgg
Mapping_targetT07G12
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00026986
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (127)
LaboratoryCB
NFB
OH
CHB
StatusLive
AffectsGeneWBGene00001867
TranscriptT07G12.12a.1 (12)
GeneticsInterpolated_map_positionIV4.63927
Mapping_dataIn_2_point317
In_multi_point (12)
In_pos_neg_data961
968
969
4251
4689
DescriptionPhenotypeWBPhenotype:0000583Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
RemarkAnimals segregate 5% XXX (Dumpy) progeny.Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
PenetranceLowPaper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
WBPhenotype:0000742Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkAnimals exhibit reduced recombination (9%) compared to wild type.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000863Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkMales exhibit 8.8% wild type fertility.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0001175Paper_evidenceWBPaper00001077
WBPaper00000565
WBPaper00000179
WBPaper00048917
Person_evidenceWBPerson136
WBPerson261
Curator_confirmedWBPerson48
WBPerson712
WBPerson721
RemarkLittle or no autosomal missegregation.Person_evidenceWBPerson136
Curator_confirmedWBPerson48
Male self-progeny make up 30.3% population as measured from 8 broods, 895 total animals.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Animals segregate 36.7% males compared to 0.3% segregated by wild type animals.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
Self-progeny 37% XO male, 6% 3X herm, 38% nullo-X ova as a result of reductional meiotic nondisjunction X chromosome recombination specifically reduced 90% except at left end (increased). Easy to score (ES3) as progeny.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
PenetranceIncompletePerson_evidenceWBPerson136
Curator_confirmedWBPerson48
31%Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
Range3939Person_evidenceWBPerson136
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson136
Curator_confirmedWBPerson48
Ease_of_scoringES3_Easy_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001583Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkAnimals segregate a small percentage (6.4%) of short animals shown to be 3X hermaphrodites (wild type segregates 0.04% 3X herm.).Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000050Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
Remark0.8% eggs never hatch, yet are refractile, similar in percent to those from wild type animals.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000062Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
RemarkAnimals produce 4% dead embryos and L1 (n=1597), not unlike wild type, which produce 2% dead L1 (n=1755).Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
WBPhenotype:0000143Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentUV sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 1Jm 10X-2/sec. Irradiated animals were protected from light. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000154Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkAnimals have an average brood size of 30237 s.d. (6 broods counted), wild type has average brood size 33034 s.d. (8 broods counted).Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000276Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
Phenotype_assayTreatmentX-ray sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 470 r/min. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls.Paper_evidenceWBPaper00000565
Curator_confirmedWBPerson712
WBPhenotype:0000517Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkAnimals are indistinguishable from wild type in terms of behavior.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000520Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkBoth hermaphrodites and males are indistinguishable from wild type in terms of superficial anatomy.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0000673Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
RemarkAverage brood size 254 38 (n=1597)Paper_evidenceWBPaper00001077
Curator_confirmedWBPerson712
WBPhenotype:0001631Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
RemarkThe sex ratio of cross progeny sired by him males does not significantly differ from 1:1.Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000179
Curator_confirmedWBPerson712
WBPhenotype:0002140Paper_evidenceWBPaper00032050
Curator_confirmedWBPerson712
RemarkMales responded to ascr#3, an ascaroside, in male attraction assays.Paper_evidenceWBPaper00032050
Curator_confirmedWBPerson712
Reference (29)
RemarkAllele incorrectly cited as e1389Paper_evidenceWBPaper00003393
Allele incorrectly cited as e2489Paper_evidenceWBPaper00003294
Variation stub/paper connection generated from the May 2021 NN VFP dataset.
Created by WBPerson51134 from the NN_VFP_triage_pipeline
MethodSubstitution_allele