WormBase Tree Display for Variation: WBVar00241392

WBVar00241392 Name: Public_name: r861
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00034943
    Laboratory: TR
    Status: Live
  Affects: Gene: WBGene00004879
    Interactor (12)
  Genetics: Mapping_data: In_multi_point: 1889
        1890
  Description: Phenotype: WBPhenotype:0000697 Paper_evidence: WBPaper00032237
        Curator_confirmed: WBPerson712
        Penetrance: High: 94%; n=205 Paper_evidence: WBPaper00032237
              Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00032237
            Curator_confirmed: WBPerson712
      WBPhenotype:0001538 Paper_evidence: WBPaper00001192
          WBPaper00001813
        Curator_confirmed: WBPerson2021
        Remark: Isolated as a suppressor of unc-54(r293). This allele exhibits morphological abnormalities in the genitalia Paper_evidence: WBPaper00001192
            Curator_confirmed: WBPerson2021
          Increases the steady state level of unc-54 mutant mRNAs (altered 3' UTR and nonsense mutations). Paper_evidence: WBPaper00001813
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001192
            WBPaper00001813
          Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000039 Paper_evidence: WBPaper00032237
        Curator_confirmed: WBPerson712
        Remark: The average lifespan was not increased compared to wild-type animals. Paper_evidence: WBPaper00032237
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00032237
            Curator_confirmed: WBPerson712
      WBPhenotype:0000436 Paper_evidence: WBPaper00032237
          WBPaper00040857
        Curator_confirmed: WBPerson712
        Remark: DAF-16::GFP was localized in both the cytoplasm and nuclei of all tissues at all developmental stages, like that in control animals. Paper_evidence: WBPaper00032237
            Curator_confirmed: WBPerson712
          Mutation did not cause SNB-1::VENUS localization defects. Paper_evidence: WBPaper00040857
            Curator_confirmed: WBPerson712
        Variation_effect: Null: Paper_evidence: WBPaper00032237
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: daf-16::GFP Paper_evidence: WBPaper00032237
              Curator_confirmed: WBPerson712
      WBPhenotype:0001828 Paper_evidence: WBPaper00004325
        Curator_confirmed: WBPerson2021
        Remark: smg-1 homozygotes behaved like WT worms and did not recover from RNAi at all Paper_evidence: WBPaper00004325
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: RNAi injection Paper_evidence: WBPaper00004325
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00040857
    WBPaper00032237
    WBPaper00014840
    WBPaper00004325
    WBPaper00010429
    WBPaper00001192
    WBPaper00001813
  Method: Allele