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WormBase Tree Display for WBProcess: WBbiopr:00000124

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Name Class

WBbiopr:00000124Public_nameCuticle biogenesis
SummaryThe C. elegans cuticle is a protective exoskeleton of specialized extracellular matrix (ECM) consisting primarily of collagen, lipids, and glycoproteins and is required for viability. (Chisholm and Hardin 2005; Page and Johnstone 2007). The cuticle determines the shape of the body and, through connection from the epidermis to muscle, provides anchoring points for muscle contraction. The cuticle also serves as a model for ECM formation and function with molecules and pathways involved in cuticle biogenesis conserved in vertebrates (Page and Johnstone 2007). The outer epithelial layer, the epidermis, of the embryo undergoes a series of cell fusions to make large multinucleate, or syncytial, epidermal cells, which secrete the materials needed to make up the cuticle. This protective layer is produced five times during C. elegans development, with each molt ending with an entirely new cuticle.
Involved_entityGene (23)
InteractionWBInteraction000540322
WBInteraction000556281
Associated_withPhenotypeWBPhenotype:0000021Paper_evidenceWBPaper00006244
WBPhenotype:0000022Paper_evidenceWBPaper00006244
WBPhenotype:0000025Paper_evidenceWBPaper00006244
WBPhenotype:0000501Paper_evidenceWBPaper00006244
WBPhenotype:0000502Paper_evidenceWBPaper00006244
WBPhenotype:0000583Paper_evidenceWBPaper00006244
WBPhenotype:0000645Paper_evidenceWBPaper00006244
WBPhenotype:0001012Paper_evidenceWBPaper00006244
WBPhenotype:0001415Paper_evidenceWBPaper00006244
WBPhenotype:0001840Paper_evidenceWBPaper00006244
GO_termGO:0042338
GO:0042335
ReferenceWBPaper00006244