WormBase Tree Display for Analysis: Microarray_Study.WBPaper00005475.ce.mr

Microarray_Study.WBPaper00005475.ce.mr DB_info: Database: GEO GSE4005
  Title: Aging time course
  Description: Transcriptional Profile of Aging in C. elegans Whole-genome analysis of gene expression during chronological aging of the worm provides a rich database of age-specific changes in gene expression and represents one way to distinguish among these models. Using a rigorous statistical model with multiple replicates, we find that a relatively small number of genes (only 164) show statistically significant changes in transcript levels as aging occurs (<1% of the genome). Expression of heat shock proteins decreases, while expression of certain transposases increases in older worms, and these findings are consistent with a higher mortality risk due to a failure in homeostenosis and destabilization of the genome in older animals. Finally, a specific subset of genes is coordinately altered both during chronological aging and in the transition from the reproductive form to the dauer, demonstrating a mechanistic overlap in aging between these two processes. Groups of assays that are related as part of a time series. Age: Age of organism Keywords: time_series_design
  Category: aging
  Microarray_experiment: [cgc5475]:day12-14
    [cgc5475]:day16-19
    [cgc5475]:day3
    [cgc5475]:day4
    [cgc5475]:day6-7
    [cgc5475]:day9-11
  Species_in_analysis: Caenorhabditis elegans
  Reference: WBPaper00005475