WormBase Tree Display for Construct: WBCnstr00015798
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WBCnstr00015798 | Summary | [LIN-45(AA,V627E)] | |
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Gene | WBGene00003030 | ||
Construction_summary | Alanine substitutions were introduced into the central threonine and +4 serine residues (T432A/S436A). The substitution V627E is analogous to Braf(V600E) in human BRAF; the amino acid substitution V600E is frequently found in cancers and renders the kinase constitutively active and independent of Ras activity. | ||
Used_for | Transgene_construct | WBTransgene00016233 | |
Reference | WBPaper00041737 |