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WormBase Tree Display for Construct: WBCnstr00015798

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Name Class

WBCnstr00015798Summary[LIN-45(AA,V627E)]
GeneWBGene00003030
Construction_summaryAlanine substitutions were introduced into the central threonine and +4 serine residues (T432A/S436A). The substitution V627E is analogous to Braf(V600E) in human BRAF; the amino acid substitution V600E is frequently found in cancers and renders the kinase constitutively active and independent of Ras activity.
Used_forTransgene_constructWBTransgene00016233
ReferenceWBPaper00041737