WormBase Tree Display for Disease_model_annotation: WBDOannot00001066
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| WBDOannot00001066 | Disease_term | DOID:162 | |
|---|---|---|---|
| Disease_of_species | Homo sapiens | ||
| Modeled_by | Variation | WBVar00092209 | |
| Asserted_gene | WBGene00014025 | ||
| Association_type | is_implicated_in | ||
| Evidence_code | GO_code | IMP | |
| ECO_term | ECO:0007013 | ||
| Modifier_info | Modifier_molecule | WBMol:00002867 | |
| Modifier_association_type | condition_ameliorated_by | ||
| Genetic_sex | hermaphrodite | ||
| Paper_evidence | WBPaper00061328 | ||
| Disease_model_description | An ASNA-1 point mutant, in which the protein preferentially was found in the oxidized state, is sensitive to cisplatin, a frontline cancer therapeutic; ASNA-1 acts as a redox-sensitive target for cisplatin cytotoxicity and suggests that treatments that promote an oxidizing tumor environment may offer possible means to combat cisplatin resistance. | ||
| Curator_confirmed | WBPerson324 | ||
| Date_last_updated | 18 Oct 2021 00:00:00 |
