WormBase Tree Display for Disease_model_annotation: WBDOannot00001365
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WBDOannot00001365 | Disease_term | DOID:11722 | |
---|---|---|---|
Disease_of_species | Homo sapiens | ||
Modeled_by | Strain | WBStrain00043193 | |
Association_type | is_model_of | ||
Evidence_code | GO_code | IMP | |
ECO_term | ECO:0007013 | ||
Genetic_sex | hermaphrodite | ||
Paper_evidence | WBPaper00056402 | ||
Disease_model_description | Myotonic dystrophy type 1 (DM1) is an autosomal-dominant inherited disorder caused by the expansion of CTG repeats in the 3 prime untranslated region of the DMPK gene. The RNAs bearing these expanded repeats have a range of toxic effects. The C. elegans DM1 model expresses 123 CUG repeats (123CUG) and exhibits motility defects and an increased susceptibility to stress. | ||
Curator_confirmed | WBPerson324 | ||
Date_last_updated | 21 Nov 2022 00:00:00 |