WormBase Tree Display for Expr_pattern: Expr10205
expand all nodes | collapse all nodes | view schema
| Expr10205 | Expression_of | Gene | WBGene00000424 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00000424 | |||
| Expression_data | Anatomy_term | WBbt:0005792 | Certain | |
| GO_term | GO:0005769 | |||
| GO:0055037 | ||||
| Subcellular_localization | GFP-CED-10 localized to intracellular puncta in the cytoplasm. The authors identified the intracellular puncta labeled by CED-10 as endosomes by performing a series of colocalization studies with a previously established set of intestine-specific compartment markers. CED-10 appeared specifically enriched on endosomes along the early and recycling pathway. Direct overlap of intestinal GFP-CED-10-labeled puncta and a subset of early endosomes marked by RFP-RAB-5 was observed. GFP-CED-10 showed the strongest colocalization with recycling endosome marker RFP-RAB-10, and displayed less overlap with later acting recycling endosome protein RFP-RME-1. Little overlap was observed between GFP-CED-10 and markers for late endosomes (GFP-RAB-7), the Golgi (MANS-GFP), or multi-vesicular bodies (GFP-HGRS-1/Hrs) indicating specificity in endosome-type associated with CED-10. | |||
| Type | Reporter_gene | |||
| Pattern | GFP- CED-10 localized strongly to the apical domain of intestinal epithelial cells (likely to the microvilli). | |||
| Picture | WBPicture0000012786 | |||
| WBPicture0000012787 | ||||
| Reference | WBPaper00041307 | |||
| Transgene | WBTransgene00031359 |
